- Design and execute protein expression and purification experiments to enable drug discovery initiatives and assess new targets.
- Investigate ligand-protein interactions using an array of biophysical and biochemical methods.
- Explore molecular mechanisms of protein-altering genetic variants and ligands using structural and biophysical methods.
- Interpret and present findings, contributing insights in cross-functional research team meetings.
- Contribute to reports and scientific publication writing.
Skills and Qualifications:
- PhD in Biochemistry/Biophysics/Structural Biology with relevant experience or BS/MS with equivalent industry background.
- Demonstrated proficiency with multiple protein expression systems (bacterial, insect, mammalian).
- Technically adept in protein characterization with various biochemical and biophysical methods (DSF, SPR, MST, MS).
- Working knowledge of structural biology methods and computational structural analysis tools (PyMOL, ChimeraX, AF2).
- Experience with multi-subunit protein complexes and membrane proteins is a plus.
- Ability collaboratively and work with cross-functional teams.
About Maze TherapeuticsMaze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass PlatformTM, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass PlatformTM, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for the Scientist I, Protein Science position for employees located in the San Francisco Bay Area is $117,000 - $143,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
-
Protein Sciences Intern
4 days ago
Nurix Therapeutics San Francisco, United StatesPosition: Intern · Duration: 10 weeks · Project Description: Expression, purification and characterization of proteins for small molecule drug discovery. · Manager Name: Hugo Bousquet · Department: 210 – Protein Sciences · Internship Job Description: · We are seeking a motivated ...
-
scientist/senior scientist, protein sciences
1 week ago
Adicet Bio, Inc. Redwood City, United States Full timeJOIN US · Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptor ...
-
scientist/senior scientist, protein sciences
1 week ago
BioSpace Redwood City, CA, United StatesJob Details · JOIN US · Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of off-the-shelf gamma delta T cells, engineered with chimeric antigen receptors (CARs) ...
-
Senior Research Associate I, Protein Sciences
12 hours ago
OmniAb Emeryville, United StatesJob Description · Job DescriptionAbout OmniAb · OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art tech ...
-
Cognasent Oakland, United StatesJob Description · Job DescriptionAbout Us: · Cognasent Scientific is a top recruiting company bridging the gap between exceptional talent and extraordinary opportunities in science and engineering. Our client is a dynamic startup dedicated to revolutionizing the cheese industry w ...
-
Associate Scientist
1 week ago
Soleil Labs, LLC South San Francisco, United States**Associate Scientist - Scientist I** IN VITRO PHARMACOLOGY**: · **May 2024**: · **Department**:Biology**: · ***: · **Work Location**: Corporate Headquarters (South San Francisco)**: · ***: · **Position Summary**: · ***: · **Responsibilities**: · - Collaborate with in vivo pharma ...
-
Research Scientist: Biochemist with Strong
3 days ago
SyntheX San Francisco, United States**Research Scientist: Biochemist with Strong Molecular Biology Background** · **Brief Description of SyntheX** · SyntheX is using synthetic biology and genetic engineering to discover first in class therapeutics to modulate protein interactions. We've built two platforms based on ...
-
Staff Research Associate I
1 day ago
University of California San Francisco San Francisco, United StatesThe Brain Tumor Center at UCSF focuses on developing new treatments for patients with malignancies of the central nervous system by · - (1) studying the mechanisms through which brain tumors develop and become resistant to treatments and · - (2) identifying novel therapeutic targ ...
-
Director, Quantitative Pharmacology
5 days ago
Amgen San Francisco, United States**HOW MIGHT YOU DEFY IMAGINATION?** · If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collabor ...
-
Research Associate
3 days ago
Fladger Associates Foster City, United StatesResponsibilities: · - Excellent employment opportunity for a Research Associate - Protein Therapeutics in the Foster City, CA area. (onsite) · - Seeking a highly motivated Research Associate to join our protein purification and QC group within the Protein Therapeutics Department. ...
-
Scientist 1
1 week ago
ICONMA South San Francisco, United States· The departments of Biomolecular Research and Structural Biology, within the Protein Sciences · organization at Client are looking for a versatile, dynamic, self-motivated individual to join us as a Scientist 1. · The selected individual will contribute towards recombinant prot ...
-
Senior Scientist
6 days ago
BEPC Inc. - Business Excellence Professional Consulting South San Francisco, United StatesBEPC has an open position for a Scientist 1 (Protein Expression and Purification, Contract role) · Contract W2 Period: 12-month contract with possibilities for extensions · Pay & Benefits: $43-$50/hr. + Medical, Dental, Vision and Life Insurance · The departments of BioMolecular ...
-
Research Associate
3 days ago
Alector, Inc. South San Francisco, United StatesWe are seeking a research associate in the ADPE group (12-month contract). The candidate is expected to support the Protein Sciences team in providing high-quality biologics in a timely manner for biochemical, biophysical, and biological characterizations to drive the advancement ...
-
Research Associate, Protein Engineering
5 days ago
Stanford University Stanford, United States**SCHOOL/UNIT DESCRIPTION**: · Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The prox ...
-
Revolution Medicines Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS p ...
-
Research Associate, Protein Screening
6 days ago
Alpine Bio South San Francisco, United StatesNobell Foods is creating cheese and other dairy products from plant-derived dairy proteins for the 99% of people who are unwilling to compromise on taste and price. Nobell is made up of a team of passionate scientists, explorers, and storytellers on a mission to radically change ...
-
Scientist
6 days ago
R&D Partners South San Francisco, United StatesBiotechnology company is hiring a Scientist to contribute towards recombinant protein expression and purification efforts to support drug discovery activities. You will facilitate expression analysis of novel protein encoding constructs by utilizing high throughput processes for ...
-
Sr Research Associate- Protein Purification
1 week ago
Meet South San Francisco, United StatesThe Company · Our client is a well funded California Biotech focused on the how the body ages with a fantastic pipeline . · The Role · They are looking for a Regulatory Affairs contractor for 10 hrs a week, who will be responsible for aiding and working in a fast pace accelerated ...
-
Project Scientist Full-time
4 days ago
Innova Solutions South San Francisco, CA, United States Full timeInnova Solutions is immediately hiring Scientist 1. · Fulltime - Contract · The departments of BioMolecular Research and Structural Biology, within the Protein Sciences organization at Client are looking for a versatile, dynamic, self-motivated individual to join us as a Scient ...
-
Contract - Research Associate (DMPK)
6 days ago
Cytokinetics, Incorporated South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
Scientist I, Protein Sciences - South San Francisco, United States - Maze Therapeutics
Description
The Position:
At Maze Therapeutics, we're focused on translating cutting-edge genetic insights into lifesaving medicines. Our scientists decode the genetic drivers of disease and leverage our findings to develop innovative therapeutics. In this role, you'll play a crucial part by purifying and characterizing protein targets, and in partnership with Drug Discovery's Medicinal and Computational Chemistry teams you will design and optimize novel small-molecule therapeutics. Collaborating with our Translational Genomics team, you'll also delve into the biophysical mechanisms of protein-altering human genetic variants.
Your Impact:
Scientist I, Protein Sciences professionals in South San Francisco
-
Kuo-Ching Chang
Data Scientist
-
Christopher Still
Biological Data Scientist
-
Sanjay M. Satav
Sales & Business Development Manager
-
Angelisa Marie Marie Letele
B.S. | Audiology Technician | Aspiring Audiologist
-
Kenneth Chuson
Web Developer/Designer