Research Associate, Protein Engineering - Stanford, United States - Stanford University

Mark Lane

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Mark Lane

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Description

SCHOOL/UNIT DESCRIPTION:

Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences.

The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking discoveries that advance our understanding of and ability to improve human health.

Sarafan ChEM-H has partnered with Stanford Medicine to launch a bold new translational research initiative - Stanford's Innovative Medicines Accelerator (IMA).

IMA aims to accelerate the translation of scientific discoveries at Stanford University into new therapeutics that impact human health while improving our understanding of human biology.


Our VPDoR Diversity Journey:


  • We create a hub of innovation through the power of diversity of disciplines and people.
  • We provide equitable access and opportunity to all members of the community in order to do their best work, regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
  • We listen to and value all colleagues who bring diverse perspectives to the advancement and development of a respectful community.
  • We promote a culture of belonging, equity, and safety.
  • We embed these values in excellence of education, research, and operation.
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CORE DUTIES:


  • Support research programs related to discovery and development of protein therapeutics.
  • Participate in multidisciplinary project teams across different faculties or schools.
  • Maintain the IT infrastructure including databases, laboratory software and hardware.
  • Oversee IT equipment budget under supervision of principal investigator or business manager.
  • Carry out wet lab activities related to protein engineering and drug discovery.
  • Prepare periodic progress reports and written final reports.
  • Work independently toward the project objective.
  • Perform ongoing literature review to remain current with new procedures and technologies regarding protein engineering.
  • Work compliance with health and safety policies and procedures.

MINIMUM REQUIREMENTS:


Education & Experience:


Bachelor's degree in bioinformatics or related scientific field and two years of relevant work experience; or Master's degree in bioinformatics or a related scientific field.


Knowledge, Skills and Abilities:


  • Comprehensive understanding of scientific principles.
  • Basic understanding of protein chemistry, molecular biology and immunology.
  • Excellent computer skills and experience in writing short codes in Python.
  • Experience in MD simulations and structural modeling.
  • Demonstrated basic laboratory skills in molecular biology.
  • Strong analytical skills and excellent judgment.
  • Ability to maintain detailed records of experiments and outcomes.
  • Excellent team working skills, demonstrated in collaboration with senior scientists and scientific staff
  • Ability to work under deadlines with general guidance is essential.
  • Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PREFERRED QUALIFICATIONS:


  • Experience with modeling software such as Schrodinger
  • Integrating open source software like Rosetta or AlphaFold
  • Docking and modeling of proteinprotein interactions
  • Demonstrated in silico optimization of protein properties such as thermostability, affinity, or solubility
  • Handling of large data sets from deep sequencing and/or protein mass spectrometry data

Certifications and Licenses:

None


PHYSICAL REQUIREMENTS:


  • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform deskbased computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
  • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
  • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
  • Must have correctible vision to perform duties of the job.
  • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
  • Ability to lift heavy objects weighing up to 50 pounds.
  • Ability to work in a dusty, dirty, and odorous environment.
  • Position may require repetitive motion.

WORKING CONDITIONS:


  • May require working in close proximity to blood borne pathogens.
  • May require work in an environment where animals are used for teaching and research.
  • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
  • Employee must perform tasks that require the use of personal protective equipment, such as safe

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