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    Scientist 1 - South San Francisco, United States - ICONMA

    ICONMA
    ICONMA South San Francisco, United States

    1 week ago

    ICONMA background
    Full time
    Description

    The departments of Biomolecular Research and Structural Biology, within the Protein Sciences

    organization at Client are looking for a versatile, dynamic, self–motivated individual to join us as a Scientist 1.

    The selected individual will contribute towards recombinant protein expression and purification efforts to support drug discovery activities.

    This role will facilitate expression analysis of novel protein encoding constructs, by building, developing and utilizing automated high throughput processes for expression, purification and characterization for research and portfolio projects.

    The qualified candidate must be technically strong, self– driven, passionate about science, results and detail oriented.

    In this collaborative role, the successful candidate will have the opportunity to work with other scientists and group leaders within and outside our department to fulfill protein production needs.

    Protein purification using a variety of chromatographic techniques (affinity, size exclusion, ion exchange) for structural and biochemical studies.

    Screening and optimizing expression and purification of challenging membrane proteins using detergent lysis.

    Using various expression platforms such as E.coli, insect cells (BEVS), and mammalian expression platforms for small and medium scale protein production.

    Performing SDS–PAGE, western blot, protein characterization assays by different biophysical and biochemical methods.

    Operating and maintaining High performance liquid chromatography systems (HPLC) for protein purification and analysis.

    Performing gel analysis, capturing and interpreting data, uploading results to LIMS databases and sharing with stakeholders.

    Communicating with and presenting to collaborators and stakeholders across the Protein Sciences organization.

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