- Work alongside other team members in protein sciences to express, purify, and characterize diverse proteins ranging from antigens to engineered antibody-like molecules that meet project goals and timelines.
- Oversee all activities related to recombinant protein expression in the group, including maintenance of Expi293 and ExpiCHO expression lines, and optimizing expression protocols to improve yield and/or solubility of proteins.
- Develop and optimize high-throughput small-scale protein expression and purification methods to enable screening of antibodies and antibody fragments.
- Optimize and troubleshoot expression and purification strategies for proteins that are challenging to produce.
- Train and serve as a mentor at the bench for other scientists on the team.
- Lead multiple efforts to design new expression and purification strategies for antibody fragments (e.g. minibody, scFv-IgG, scFv-Fc, diabody).
- Serve as a subject matter expert in protein sciences in broader project-focused or group-focused team meetings.
- Communicate regularly with cross-functional teams across Adicet on deliverables, timelines, and progress.
- Lead efforts to improve notebook templates, write SOPs, and develop training documents.
- Maintain and keep records of all data and studies according to existing templates.
- Responsible for maintenance, training, and documentation for critical instrumentation in protein sciences.
- PhD in chemistry, biochemistry, or chemical biology with at least 3-5 years of experience in an industry setting. MS with 10 years or more experience. Title will be dependent on experience.
- Strong desire to work at the bench in a fast-paced and highly collaborative research environment.
- Demonstrates a "can-do" attitude, can step up when necessary to assist other lab members without asking, willingness to help and improve lab environment for team members.
- Must possess excellent verbal and written communication skills with prior experience serving as an SME on cross-functional teams.
- Highly proficient in PowerPoint, word, outlook, and excel. Previous experience in Prism and/or Benchling a bonus, but not a requirement.
- Candidate must be highly organized and detailed oriented and able to juggle competing projects and timelines.
- Candidate must have extensive experience maintaining cell lines and have prior experience working in a BSC. Bonus if the candidate has previously used Expi293 and ExpiCHO cell lines for recombinant protein expression and/or has experience optimizing recombinant expression of proteins.
- Significant prior experience maintaining and troubleshooting complex analytical equipment, such as HPLC, MALS, ViCell, AKTA Pure, Endosafe.
- Deep understanding of protein engineering, antibody structure and its correlation to function.
- Previous experience using display technologies (yeast, phage, or mammalian cell surface display) to isolate novel binders is a strong bonus.
- Must have prior hands-on experience purifying antibodies and antibody fragments (e.g. minibody, diabody, IgG-scFv, scFv-Fc) using a variety of affinity resins (Protein A, Protein G, and Protein L).
- Previous experience successfully developing methods to express and purify challenging proteins.
- Possess a working knowledge and understanding of HIC, IEX, and SEC methods. Bonus if previous experience includes deep knowledge of different resins for each purification strategy and/or hands-on experience with all strategies.
- Must be extremely comfortable developing methods, analyzing data, and optimizing purifications on AKTA systems (bonus if prior experience includes AKTA Pure).
- Prior hands-on experience conjugating antibodies to fluorophores or other small molecules.
- Bonus if prior experience includes conjugation using diverse chemistries (e.g. non-specific amine based labeling and site-specific labeling methods).
- Prior experience with other functional assays (Kd determination by Octet, thermal stability measurements, long-term stability assays, protein ELISAs, western blots, dot blots, in-cell western assays, SEC-MALS)
-
scientist/senior scientist, protein sciences
6 days ago
Adicet Bio, Inc. Redwood City, United States Full timeJOIN US · Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptor ...
-
Research Associate II, Protein Sciences
1 week ago
Pheast Therapeutics Palo Alto, United StatesSummary: · Pheast is seeking an enthusiastic and creative Research Associate to join the Protein Sciences group. This candidate will carry out routine mammalian tissue culture, transfections, protein biochemistry, molecular biology and related tasks. The candidate will also colla ...
-
scientist/senior scientist, protein sciences
3 weeks ago
Adicet Bio, Inc. Redwood City, United States Full timeJOIN US Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off–the–shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors ...
-
Director, Protein Sciences
3 weeks ago
Merck South San Francisco, United States Full timeJob Description · We are seeking an exceptional and experienced scientist to join the Discovery Biologics Protein Sciences department in South San Francisco to lead both functional area scientists and drug discovery programs. The Director of Protein Sciences role carries manageri ...
-
Scientist I, Protein Sciences
1 week ago
Maze Therapeutics South San Francisco, United States Full timeThe Position: · At Maze Therapeutics, we're focused on translating cutting-edge genetic insights into lifesaving medicines. Our scientists decode the genetic drivers of disease and leverage our findings to develop innovative therapeutics. In this role, you'll play a crucial part ...
-
Senior Research Associate I, Protein Sciences
3 weeks ago
OmniAb, Inc. Emeryville, United StatesAbout OmniAb · OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art technologies to facilitate the discove ...
-
Senior Research Associate I, Protein Sciences
4 weeks ago
OmniAb Emeryville, United StatesJob Description · Job DescriptionAbout OmniAb · OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art tech ...
-
Cognasent Oakland, United StatesJob Description · Job DescriptionAbout Us: · Cognasent Scientific is a top recruiting company bridging the gap between exceptional talent and extraordinary opportunities in science and engineering. Our client is a dynamic startup dedicated to revolutionizing the cheese industry w ...
-
Associate Research Scientist
2 weeks ago
Galvanize Therapeutics, Inc. Redwood City, United StatesGalvanize is a biomedical platform company operating at the convergence of engineering, biology, and healthcare delivery, aiming to deliver life-changing solutions to patients and their doctors. We design and develop Pulsed Electric Field Systems to achieve meaningful and lasting ...
-
Research Associate II, Assay Development
2 weeks ago
Adverum Biotechnologies, Inc. Redwood City, United StatesResearch Associate II, Assay Development (Contract) · Redwood City, CA · Research & Development – Assay Development / · Adverum is looking for a Research Associate II or III to join our team in our Redwood City office. This position reports to a Scientist/Team Leader in Assay De ...
-
Bioprocess Development Research Associate III
7 hours ago
Codexis Redwood City, United StatesBioprocess Development Research Associate III · Department: · 48 - Bioprocess Development · Employment Type: · Full Time · Location: · Redwood City, CA · Description · Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a · Bioprocess Developme ...
-
Codexis Redwood City, United StatesBioprocess Development Research Associate III · Department: · 48 - Bioprocess Development · Employment Type: · Full Time · Location: · Redwood City, CA · Description · Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a · Bioprocess Development ...
-
Codexis Redwood City, United States· Department · 48 - Bioprocess Development · Employment Type · Full Time · Location · Redwood City, CA · Workplace type · Onsite · Description · Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a Bioprocess Development Research Associate III. ...
-
REVOLUTION Medicines Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS p ...
-
Director, Medical Safety Science
1 day ago
Third Rock Ventures Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS p ...
-
Vice President, Clinical Science
3 weeks ago
Revolution Medicines, Inc. Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS p ...
-
Vice President, Clinical Science
1 day ago
Third Rock Ventures Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic varian ...
-
Senior Manager Business Development
3 weeks ago
Adverum Biotechnologies, Inc. Redwood City, United StatesThe Senior Manager/Associate Director of Business Development will be a key contributor to the organization. This individual will provide strong business leadership in assessing and guiding the long-range strategic direction through acquisitions, joint ventures, strategic allianc ...
-
Associate Director/Director, Drug Product, PD
3 weeks ago
Adverum Biotechnologies, Inc. Redwood City, United StatesAdverum is looking for an Associate Director / Director, Head of Drug Product Process Development (Drug Product PD) to join the Technology Development team at our Redwood City, CA office. This position is a key leadership role that focuses on advancing Adverum's lead program, ADV ...
-
Senior Scientist I, Translational Medicine
3 weeks ago
Revolution Medicines, Inc. Redwood City, United StatesRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS p ...
scientist/senior scientist, protein sciences - Redwood City, United States - BioSpace
Description
Job DetailsJOIN US
Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors (CAds), to enhance selective tumor targeting and facilitate innate and adaptive anti-tumor immune response for durable activity in patients. For more information, please visit our website at .
SCIENTIST/SENIOR SCIENTIST, PROTEIN SCIENCES
We are seeking an enthusiastic protein scientist with a strong passion for working at the bench, problem solving, and mentoring junior scientists. The candidate will work on a small team that is responsible for recombinant expression, purification, conjugation, and characterization of diverse proteins to support a wide range of projects in our pipeline. The ideal candidate will have expertise in protein engineering techniques, including phage, yeast, or mammalian cell display, experience optimizing expression and purification of antibody fragments (e.g. minibody and Fc-fusions) and have a working knowledge of antibody structure and function. They will work on diverse program teams and represent the protein sciences group as a subject matter expert. They should be highly organized, timeline-driven, and able to execute and drive projects to completion. This position is 100% on the bench.
KEY RESPONSIBILITIES:
Adicet Bio offers both comprehensive benefits and Paid Time (PTO) plans for employees, which begin on the first day of employment, as well as the opportunity to work in a growing, dynamic environment.
Adicet Bio is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Pay Range$122,000-$168,000 USD
At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting cancer.
Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, abundant, zero-cost, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company subsidized lunches (delivered onsite daily) and fully stocked breakrooms.
In compliance with California's pay transparency law and in pursuit of pay equity and fairness, we publish salary ranges for all open positions. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, their qualifications (education, experience, specialty, and training), and peer and market data. This listed salary range represents the Company's good faith and reasonable estimate of the range of possible compensation at the time of posting.
