- Design and generate DNA vector constructs for protein expression (including monoclonal antibodies and antibody-like molecules)
- Optimize the vector workflow to increase speed and throughput
- Perform genetic characterization of CHO cell banks to confirm identity and evaluate quality of transgene DNA and RNA.
- Review DNA sequencing data (including NGS), Southern/Northern blots, quantitative PCR results
- Perform routine molecular screens of CHO cell lines using ddPCR and MinION, P2 sequencers
- Author technical reports that meet expectations of regulatory agencies for all stages from IND to BLA
- Present updates at team meetings and collaborate closely with others in the cell line development group.
- Actively seek opportunities to optimize or enhance the molecular characterization workflow.
- Display effective organization, verbal and written communication skills, and adherence to good documentation practices.
- Proficiency with basic molecular biology techniques (molecular cloning, plasmid preps, DNA digests/gels, PCR/qPCR, DNA sequencing), sterile technique, and mammalian cell culture.
- Strong understanding of mammalian cell biology and molecular biology concepts.
- Independently generate precise, reliable and reproducible data in a timely manner. Demonstrate experimental precision and strong data interpretation skills and should possess understanding of core discipline.
- Excellent attention to detail and ability to keep detailed written records in lab notebook on a daily basis.
- Proficiency with Microsoft Office software, ability to learn new software applications.
- Proficiency with Geneious software.
- Ability to learn, understand, and execute new scientific techniques.
- Ability to multi-task and work within timelines.
- Ability to work collaboratively within and outside of group.
- Strong communication skills - verbal, written, scientific data presentation.
- Background in CHO cell line development for GMP applications within biotech/pharma industry.
- Hands-on experience using Illumina and Nanopore sequencers running RNA-seq workflow and analysis
- Experience with ddPCR
- Experience in bioinformatics software to analyze DNA and RNA for sequence confirmation and expression analysis
- Familiarity with genome browser (IGV) and familiarity with NGS data file formats
- Ability to use bioinformatics tools such as "FASTQC", Samtool, and other related tools to carry out basic NGS analysis
- Proficiency in programming/data science languages, such as R, Python, and Java
- Understanding of cell biology and bioprocess engineering concepts
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
-
Lead Group Product Manager, Search Developer
1 week ago
Google Mountain View, United States**Minimum qualifications**: · - Bachelor's degree or equivalent practical experience. · - 10 years of experience in product management, consulting, co-founder or related technical role. · - 5 years of experience in people management, with technical leadership. · - 5 years of expe ...
-
Master Social Worker
1 week ago
Business Integra Inc South San Francisco, United StatesJob Summary: · **Responsibilities**: · - Conduct diagnostic evaluations and assessments to identify clients' needs · - Provide individual and group counseling sessions · - Develop treatment plans tailored to each client's specific requirements · - Maintain accurate and confidenti ...
-
Associate Scientist
1 week ago
Soleil Labs, LLC South San Francisco, United States**Associate Scientist - Scientist I** IN VITRO PHARMACOLOGY**: · **May 2024**: · **Department**:Biology**: · ***: · **Work Location**: Corporate Headquarters (South San Francisco)**: · ***: · **Position Summary**: · ***: · **Responsibilities**: · - Collaborate with in vivo pharma ...
-
Medical Social Worker II- Grade 10
3 days ago
Kaiser South San Francisco, United States Part timeJob Summary: · The primary role of the Medical Social Worker II is to assist patients and families/caregivers to cope with the social/emotional issues and practical arrangements related to the patients illness. Under general direction of the Social Work Manager/LCSW, delivers ag ...
-
Scientist, Mass Spectrometry
1 week ago
Parvus Therapeutics South San Francisco, United States**Parvus Therapeutics Inc.** · **About Navacims** · Navacims are a novel first-in-class nanomedicine designed to treat autoimmune disease by selectively modulating disease-specific cellular responses without impairing normal immunity. Navacims specifically target and act only on ...
-
ORIC Pharmaceuticals, Inc. South San Francisco, United States**Associate Director, IT Enterprise Applications (G&A)** · *** · - Reporting to the Director of IT Enterprise Applications, the Associate Director, IT Enterprise Applications will serve as the IT business partner to the general and administrative (G&A) functions at ORIC. In this ...
-
Manufacturing Associate
1 week ago
Infobahn Softworld Inc South San Francisco, United States**What is a nice to have (but not required) skill,experience, education, or certification? **PhD 3 year+ is preferred · **Responsibilities include**: · - Innovate, develop, optimize, and scale-up purification processes · - Conceive and evaluate novel advanced separation technolog ...
-
Abdera Therapeutics South San Francisco, United States**Who we are** · Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies · - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform opt ...
-
Assistant Nurse Manager, ICU
3 days ago
Kaiser South San Francisco, United States Full time"External Candidates Eligible for Sign On Bonus" · Job Summary: · Manages activities of the unit(s), monitors quality, service and utilization standards. Supervises the day to day shift activities. · Essential Responsibilities:Manages the units day to day clinical operations incl ...
-
General Sales Manager
6 days ago
Mercedes-Benz of San Francisco South San Francisco, United States**Benefits** · - Group Health Plan · - Paid Holidays · - Paid Time Off · - 401k Plan · - Employee Discounts · - Voluntary Insurance · - Employee Assistance Program · - Flexible Spending Account Plan · - Collaborate Team Environment · - Career Progression and Advancement · **Respo ...
-
Remegen Biosciences, Inc. South San Francisco, United States Freelance**ORGANIZATION** · RemeGen Biosciences is a biopharmaceutical company, focusing on the discovery and development of innovative medicines for the treatment of cancer and autoimmune diseases, based in South San Francisco, California, and Rockville, Maryland. By leveraging our deep ...
-
CRNA - S San Francisco - Full-time
3 days ago
Kaiser South San Francisco, United States Full time$53,000 + sign-on bonus eligible · Job Summary: · Selects and administers intravenous, spinal and other anesthetics prior to and during surgical or medical procedures, as a member of the anesthesia care team and in accordance with Kaiser Permanente policies and procedures. Monito ...
-
College Success Manager
1 week ago
Boys & Girls Clubs of the Peninsula South San Francisco, United States**POSITION** · College Success Manager - North County · **OUR MISSION** · To empower the youth in our community with equitable access to social, academic, and career opportunities to thrive · **OUR VISION** · All youth grow up to lead fulfilling lives fueled by their passions, ta ...
-
Psychological Asst
3 days ago
Kaiser Brisbane, United States Full timeJob Summary: · Under the supervision of a licensed Psychologist or board certified Psychiatrist, provides mental health assessment, diagnosis, treatment and crisis intervention services for adult and/or child members who present themselves for psychiatric evaluation with a broad ...
-
Marketing Project Manager
4 days ago
Cella San Bruno, United States**Location: Hoboken, New Jersey** · **Job Type: Contract** · **Compensation Range: $ per hour** · We are looking for an experienced **Marketing Project Manager** to join our leading retail client in the San Bruno area · **Responsibilities**: · - Help project manage the work for t ...
-
Behavior Technician
1 week ago
Trumpet Behavioral Health San Bruno, United StatesOverview: · Make a positive and unforgettable impact of the lives of children with autism spectrum disorder Trumpet Behavioral Health (as part of the BlueSprig family of companies) is looking for driven individuals that love to work with kids, make a difference, be a part of a co ...
-
Behavior Technician
1 week ago
BlueSprig San Bruno, United States: · Make a positive and unforgettable impact of the lives of children with autism spectrum disorder Trumpet Behavioral Health (as part of the BlueSprig family of companies) is looking for driven individuals that love to work with kids, make a difference, be a part of a collaborat ...
-
UX Designer, Youtube
1 week ago
YouTube San Bruno, United States**Minimum qualifications**: · - Bachelor's degree in Design, Human-Computer Interaction, Computer Science, a related field, or equivalent practical experience. · - 4 years of experience in product design or UX. · - 2 years of experience in design systems. · - 1 year of experience ...
-
Manager, Program Management
2 days ago
Walmart San Bruno, United StatesPosition Summary... · What you'll do... · As a Program Manager at the dynamic Project Management Office (PMO) of Walmart Fulfillment Services (WFS), your role will be to lead impactful initiatives across the organization. You'll work closely with a diverse group of stakeholders, ...
-
Walmart San Bruno, United StatesPosition Summary... · What you'll do... · **Manager, Program Management, Recruitment Marketing - Talent Acquisition** · Ecommerce has a lot of moving parts, especially marketplace platforms. Billions of items available to millions of customers creates lots of opportunity to make ...
Associate Scientist II orScientist I, CMC Drug Substance Cell Line Development Group - South San Francisco, United States - AbbVie
Description
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.
We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio.
For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.Job Description
The Development Sciences Biologics CMC Drug Substance Cell Line Development Group in South San Francisco, CA is seeking a Scientist to join a talented and collaborative team developing CHO cell lines for GMP applications.
In this laboratory position, the candidate will perform hands-on molecular characterization studies in a well-supported and dynamic environment to help advance novel therapies to human clinical studies.
The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.
Key Responsibilities:
Associate Scientist II - Bachelor's Degree, or equivalent education, with typically 3 or more years' experience or Master's Degree or equivalent education (no additional experience)
Scientist I - Bachelor's Degree or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically two years of experience.
Preferred:
No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable.
The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
Additional InformationAbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.
It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
