Scientist, Mass Spectrometry - South San Francisco, United States - Parvus Therapeutics

Description

Parvus Therapeutics Inc.

About Navacims

Navacims are a novel first-in-class nanomedicine designed to treat autoimmune disease by selectively modulating disease-specific cellular responses without impairing normal immunity.

Navacims specifically target and act only on disease causing effector T cells, delivering a signal that programs effector T cells to differentiate into regulatory T (Treg) cells specific for self-antigens relevant to the patient's disease.

These disease
- or tissue-specific Treg cells induce immunological tolerance to block undesired immune responses to self-antigens, while maintaining normal immune surveillance and activity.


The Position

Primary Responsibilities:

• Primary contributor with protein characterizing mass spectrometry experiments, including maintaining the instrument, developing and performing experiments with an emphasis on intact mass, glycan analysis and peptide mapping studies.
• Learn, develop, and perform in vitro protein and nanoparticle biophysical and binding characterization assays.
• Prepare technical documents for transfer to contract manufacturers.
• Work collaboratively in multifunctional groups to test drug substance critical quality attributes.
• Contribute scientifically to the growing knowledge base of the Parvus technology platform.
• Develop and execute detailed SOP's that can be readily transferred to outside partners and document experiments in a lab notebook.
• Present at team meetings, across Parvus, and with our business partners as needed to drive studies and provide analytical support to material production and manufacturing.

Requirements:

• Ph.

D. in biochemistry, chemistry, or a related discipline

• 01 year of handson experience in industry. Experience with mass spectrometry, with an emphasis on glycan analysis and posttranslational modification characterizations.
• Expertise setting up, maintaining, and running LC/MS equipment independently or with mínimal assistance is required.
• Expert at solving technical challenges in protein characterization and assay development.
• Experience with ELISAs is a plus.
• Analytical problem solving and organizational skills are required to identify and resolve technical challenges.
• Ability to work independently in the laboratory and in crossfunctional teams.
• Comfortable working collaboratively in a small, fastpaced environment.
• Ability to quickly adjust to shifting project demands and priorities.
• Good oral, written communication, and presentation skills.

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