- Act as the subject matter expert (SME) in Biophysical Method Development to establish methods internally and support analytical characterization work for drug substance and drug product.
- Collaborate with Contract Research Organization (CROs) and Contract Testing Laboratories (CTLs) to support product characterization activities during late-stage development including process validation batches.
- Design studies with internal Analytical Development and CROs/CTLs for virus like particle (VLP) and small molecule analytical characterization to support product licensing.
- Execute Reference Standard material qualification with AD and QC (Quality Control)
- Independently design and manage execution of experiments internally and at external partners to generate robust analytical data and work collaboratively with CDMO/CROs on design and execution of experiments.
- Author and review technical protocols and reports, CMC regulatory sections, assay summaries, study design and protocols, SOPs, etc.
- Ensure accurate and complete documentation of any data, scientific experimental plan, and report.
- Maintain equipment quality through IQ/OQ and PM
- Build and maintain good working relationships with internal and external stakeholders e.g., Pre-clinical Research, Process Development, Quality Control, Suppliers, CDMOs, CROs etc.
- Independently analyze data, present results and conclusions to the team and senior management
- Establish and maintain familiarity with contemporary industrial standards, practices, technologies, literature and ways of performing lab studies
- In depth understanding and hands on experience in one or more of the following areas are required: Analytical Ultracentrifugation (AUC), FlowCam, Nanoparticle Tracking Analysis (NTA), Microflow Imaging (MFI), Circular Dichroism (CD), FTIR, Electron Microscopy (TEM/CyroTEM), etc.
- The ability to use and maintain instrumentation, and interpret the data generated.
- Good understanding of biopharma operations, GXPs, ICH guidelines, process characterization/validation and technology transfer
- People and project management skills
- Strong communication skills
- Critical thinking and problem-solving skills
- Strong technical writing skills
- Managing multiple projects and tasks and meet deadlines with a high tolerance for ambiguity
- Author and approve protocols/reports
- Ability to function independently and communicate cross-functionally across departments
- Ability to manage priorities, and engage/communicate in a multidisciplinary environment
- Principal Scientist: PhD in a relevant scientific and biological discipline e.g., Analytical Chemistry /Biochemistry /Chemistry with 8+ years of industry experience, or master's degree with 12+ years of industry experience in relevant field
- Senior Scientist: PhD in a relevant scientific and biological discipline e.g., Analytical Chemistry /Biochemistry /Chemistry with 5+ years of post-doctoral/industry experience, or master's degree with 12+ years of industry experience in relevant field
- Experience in analytical development and characterization of particles, antibody-drug conjugate, viral vectors, or other biologics (5+ years)
-
Senior/Principal Scientist- Biophysical Characterization
Found in: Jooble US O C2 - 3 days ago
Aura Biosciences Boston, MA, United StatesAt Aura, our mission is to develop a new class of oncology targeted therapies that deliver meaningful therapeutic benefit to a range of cancer indications with high unmet need in which we believe we can establish a new standard of care. We are driven by our passion and commitment ...
-
Senior/Principal Scientist- Biophysical Characterization
Found in: ZipRecruiter Test10S US C2 - 2 days ago
Aura Biosciences Brighton, United StatesJob Description · Job DescriptionSalary: · About Aura: · At Aura, our mission is to develop a new class of oncology targeted therapies that deliver meaningful therapeutic benefit to a range of cancer indications with high unmet need in which we believe we can establish a new sta ...
-
Associate Scientist, Protein Engineering
Found in: Careerbuilder One Red US C2 - 1 week ago
Proclinical Boston, United States PermanentSenior Associate Scientist, Protein Engineering & Bioconjugation - Permanent - OnsiteProclinical is seeking a Senior Associate Scientist, Protein Engineering & Bioconjugation to join a stealth biotech company. This is a permanent role located in Boston MA. · Primary Responsibilit ...
-
Sr. Scientist/Principal Scientist- Protein Sciences
Found in: Jooble US O C2 - 3 days ago
Third Rock Ventures Boston, MA, United StatesSr. Scientist/Principal Scientist– Protein Biochemist · A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successfu ...
-
Sr. Scientist/Principal Scientist- Protein Sciences
Found in: Jooble US O C2 - 4 days ago
Third Rock Ventures Boston, MA, United StatesSr. Scientist/Principal Scientist Protein Biochemist · A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful ...
-
Sr. Scientist/Principal Scientist– Protein Sciences
Found in: Talent US 2A C2 - 3 hours ago
Third Rock Ventures Boston, United StatesSr. Scientist/Principal Scientist– Protein Biochemist · A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful ...
-
Senior Research Associate, Analytical R&D
Found in: ZipRecruiter Test10P US C2 - 2 days ago
Verve Therapeutics, Inc. Boston, United StatesJob Description · Job DescriptionThe CompanyVerve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, ...
-
Senior Scientist, Protein Analytics
Found in: ZipRecruiter Test10P US C2 - 1 day ago
Hillstar Bio Boston, United StatesJob Description · Job DescriptionHillstar Bio, a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc). · Hillstar aspires to build a portfolio of programs against autoimmune disea ...
-
Senior Research Associate, Analytical R&D
Found in: ZipRecruiter Test10P US C2 - 2 days ago
Verve Therapeutics, Inc. Boston, United StatesJob Description · Job DescriptionThe CompanyVerve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, ...
-
Director, Analytical Development
Found in: ZipRecruiter Test10P US C2 - 1 day ago
Verve Therapeutics, Inc. Boston, United StatesJob Description · Job DescriptionThe CompanyVerve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, ...
-
Associate Scientist, Protein Engineering
Found in: beBee S2 US - 1 week ago
Proclinical Staffing Boston, United StatesSenior Associate Scientist, Protein Engineering & Bioconjugation - Permanent - OnsiteProclinical is seeking a Senior Associate Scientist, Protein Engineering & Bioconjugation to join a stealth biotech company.The Senior Associate Scientist will be a motivated and curious research ...
-
head of biochemistry and biophysics
Found in: Careerbuilder One Red US C2 - 1 day ago
Third Rock Ventures Cambridge, MA , USA, United StatesMOMA Therapeutics is a biotechnology company focused on developing inhibitors of highly dynamic proteins, namely ATPases, which play critical roles in a variety of Oncology indications. Our platform allows us to successfully prosecute drug discovery against difficult and unpreced ...
-
head of biochemistry and biophysics
Found in: Careerbuilder One Red US C2 - 1 day ago
MOMA Therapeutics Cambridge, MA , USA, United StatesMOMA Therapeutics is looking for an experienced Head of Biochemistry and Biophysics · Imagine joining a company where you.... · * Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly collaborates · * Will work with ...
-
Associate Scientist, Protein Biochemistry
Found in: Appcast US C2 - 1 day ago
Third Rock Ventures Cambridge, United StatesAssociate Scientist, Protein Biochemistry · A Stealth Mode Third Rock Ventures Start Up is looking for a self-motivated and intellectually curious Associate Scientist to join our growing group. The ideal candidate has strong knowledge and bench experience in protein expression, ...
-
scientist/senior scientist, biochemistry
Found in: Careerbuilder One Red US C2 - 1 day ago
Third Rock Ventures Cambridge, MA , USA, United StatesFlare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncove ...
-
Associate Scientist
Found in: Talent US 2A C2 - 3 days ago
Elektrofi Boston, United StatesASSOCIATE SCIENTIST- TRANSLATIONAL DEVELOPMENT · ABOUT ELEKTROFI · Elektrofi is a biopharmaceutical formulation technology company that is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life- ...
-
Head of Biochemistry and Biophysics
Found in: ZipRecruiter Test10S US C2 - 2 days ago
MOMA Therapeutics Cambridge, United StatesJob Description · Job DescriptionMOMA Therapeutics is looking for an experienced Head of Biochemistry and Biophysics · Imagine joining a company where you.... · Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly ...
-
Scientist II, LNP Formulation
Found in: beBee S2 US - 3 days ago
Entrada Therapeutics Boston, United States FreelanceThe Organization · What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. · O ...
-
Scientist II, Drug Product Development
Found in: beBee S2 US - 3 days ago
Takeda Boston, United States Full timeBy clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Noticeand Terms of Use. I further attest that all information I submit ...
-
Bench Scientist
Found in: ZipRecruiter Standard US C2 - 2 days ago
Aequor Cambridge, United StatesJob Description · Job DescriptionWe are seeking a highly motivated contract scientist to join the Molecular Assessment and Profiling group in BioMedicine Design at Pfizer. The candidate will work with a talented team of scientists to develop innovative protein and RNA-based thera ...
Senior/Principal Scientist- Biophysical Characterization - Boston, MA, United States - Aura Biosciences
Description
Job Description
Job Description
Salary:
About Aura:
At Aura, our mission is to develop a new class of oncology targeted therapies that deliver meaningful therapeutic benefit to a range of cancer indications with high unmet need in which we believe we can establish a new standard of care. We are driven by our passion and commitment to science and the patients battling cancer who are relying on us to pioneer these new therapies.
We are focusing the initial development of our VDC technology platform to treat tumors of high unmet need in ocular and urologic oncology. AU-011, our first VDC candidate, is being developed for the first line treatment of primary choroidal melanoma, a rare disease with no drugs approved. Beyond primary choroidal melanoma, we are developing AU-011 in additional ocular oncology indications, including choroidal metastases. Leveraging our VDCs' broad tumor targeting capabilities, we also plan to initiate a clinical program in non-muscle invasive bladder cancer, or NMIBC, our first non-ophthalmic solid tumor indication.
Position Summary:
The Senior/Principal Scientist- Biophysical Characterization is a key technical leadership role in the Department of Analytical Development (AD) at Aura Biosciences where the candidate will contribute by developing methods and performing product characterization through state-of-the-art biophysical methods and generating data to meet regulatory expectations for the Biological License Application (BLA) of Belzupacap sarotalocan, (Bel-sar, AU-011). The data will be used in the module 3 product characterization. Successful candidate will bring the expertise to develop biophysical methods, characterization plan and draft the dossier section.
Demonstratable knowledge in multiple cutting edge analytical biophysical technologies and specific expertise in Particle characterization (e.g., AUC, EM, NTA) is important. The candidate needs to be an excellent communicator; prior knowledge of managing internal group and CROs is essential to be successful within very aggressive timeline.
This role is expected to spend 70% time managing internal lab work and the remaining time managing characterization work with collaborators (academics/CROs).
Responsibilities include but are not limited to:
Knowledge, Skills & Capabilities:
Education & Relevant Work Experience:
