Sr. Scientist/Principal Scientist- Protein Sciences - Boston, MA, United States - Third Rock Ventures

Description

Sr. Scientist/Principal Scientist Protein Biochemist

A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of biochemical and biophysical assays, crucial in advancing the companys Discovery pipeline. We are looking for an individual with outstanding communication and collaboration abilities, who excels in cross-functional, multi-disciplinary drug discovery teams. Additionally, experience in managing direct reports and coordinating with external CROs is highly valued.

Key Responsibilities:

Contribute to the overall scientific strategy and build out of the Discovery Biologics group

Design and execute a wide range of biochemical and biophysical assays for screening and characterizing protein-protein and protein-ligand interactions

Conduct stability and developability studies on biologics to inform lead candidate selection

Utilize structural, sequence, and computational tools to design protein constructs

Skillfully label and characterize protein reagents using biotin/fluorophores

Oversee external research at CROs, managing activities, assay development, and facilitating seamless data and reagent transfers internally

Proactively assess and integrate new screening technologies into the drug discovery process

Proficiently express and purify antibodies and novel biologics utilizing standard techniques

Develop and execute project plans, coordinating workflows and logistics to achieve project milestones

Effectively present research findings at internal meetings and external scientific conferences

Candidate Requirements:

Ph.D. in Biochemistry, Biophysics, Structural Biology, or related field or B.Sc./M.Sc. with 2+ years of relevant experience in the Biotech Industry.

Essential expertise in SPR (BIAcore) and proficiency in utilizing other biophysical techniques (BLI, ITC, FP, DLS) for characterizing protein-protein interactions

Proficiency in structural biology and computational tools to aid in designing of protein constructs

Strong grasp of biochemical methods for protein purification, including affinity, IEX, SEC, HIC, and MMC

Embraces new challenges and thrives in a dynamic, start-up environment

Demonstrates a strong work ethic and high motivation

Capable of working both independently and collaboratively within a team to meet deadlines and contribute to strategic company objectives

Excellent written and verbal communication skills

by Jobble