- Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high throughput analysis, and characterization of complex raw materials.
- Review, interpret, and present data within the analytical team and cross-functionally.
- Assist in authoring, reviewing, revising technical source documents to support phase appropriate comparability.
- The successful candidate may also provide technical oversights to guide analytical/QC investigations, as needed.
- Analyze, summarize, and present technical data to manager and other team members.
- Work collaboratively with other R&D team members to accomplish project goals and milestones.
- Train and mentor junior team members.
- Other duties as assigned.
- B.S. degree Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences field.
- 3+ years of relevant experience required.
- Hands on experience developing and troubleshooting analytical methods applied to complex and heterogenous systems is required (e.g. HPLC/UPLC, capillary electrophoresis, etc.).
- Previous experience developing methods for gRNA, mRNA, LNP.
- Method development experience, with a proven track record of successfully developing analytical methods.
- Ability to operate and troubleshooting HPLC/UPLC instrumentation.
- Must have hands-on experience analyzing DNA/RNA by a variety of techniques (e.g. IP-RP, IEX, LC-fluor, multi-modal LC, etc.).
- Understanding of lipid nanoparticle delivery, production, and purification
- Must be highly motivated with high quality standards for one's own work
- Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
- Comfortable communicating highly technical information.
- Attention to detail, critical analysis of data/reports, and troubleshooting abilities.
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Senior Research Associate, Analytical R&D - Boston, United States - Verve Therapeutics, Inc.
Description
Job Description
Job DescriptionThe CompanyVerve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The PositionVerve is seeking a Senior Research Associate within the Analytical Research and Development team, to support early and late-stage activities by developing, implementing, and transferring biophysical and separation methods and technologies to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA.
The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery, process development, CMC, and internal quality control groups.
Job ResponsibilitiesVerve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing AgenciesVerve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
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