- Design, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervision.
- Determine key formulation parameters to provide reproducible and effective LNPs.
- Lead the production and characterization of LNPs for various studies enabling drug discovery and pre-clinical applications.
- Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.
- Be highly organized and meticulous in documenting results in electronic lab notebooks.
- Critically evaluate and summarize data and present findings internally and to broader interdisciplinary teams.
- Effectively multitask and manage multiple projects simultaneously.
- Stay up to date on in-vivo delivery literature and industrial practice.
The Necessities
At Entrada, our passion for science, our devotion to patients and our values drives our behavior: - Humanity - We genuinely care about patients and about one another.
- Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
- Creativity - We are creative problem solvers.
- Collaboration - We are more than the sum of our parts.
- Curiosity - We have a growth mindset and push conventional thought and theory.
To thrive on our team, you will need to come with:
- Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or other relevant scientific discipline, and 2+ years of relevant experience.
- Extensive hands-on experience and deep expertise in formulating LNPs for human health applications.
- Hands-on experience in nanoparticle characterization using Ribogreen assay, DLS, HPLC, CE, UV-Vis, AGE, TEM and other analytical methods.
- Highly detail oriented with an extreme focus on the quality and reproducibility of the lipid nanoparticle formulations and a demonstrated ability to troubleshoot them.
- A strong goal-oriented team player with excellent written and verbal communication and interpersonal skills.
- A demonstrated ability to work independently with guided supervision as well as being a part of a multidisciplinary and cross-functional team while maintaining the highest ethical and scientific standards.
- Prior industry experience in the formulation of LNPs for immuno-oncology and gene editing or ocular indications is highly desirable.
- Experience with bioconjugations, reverse-phase and ion-exchange based purification and LC-MS / MALDI-TOF characterization.
- Prior experience in LNP conjugation chemistries for drug delivery
- Experience with high throughput screening assays.
- Prior experience in using LNPs in in vitro mammalian cell culture.
The Perks
By becoming a team member here at Entrada, you'll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.
Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.
Third Party Staffing AgenciesEntrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.
Privacy StatementEntrada Therapeutics, Inc. (the "Entrada," "we," "us," or "our") respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.
- Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
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Scientist II, LNP Formulation - Boston, United States - Entrada Therapeutics
Description
The OrganizationWhat's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.
Our Endosomal Escape Vehicle (EEVTM)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.
Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.
We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.
The Perfect Addition to Our Team
You are a versatile and self-motivated scientist who is comfortable working both independently with minimal supervision as well as collaboratively as a part of a larger interdisciplinary team. You shall be enthusiastic to roll up your sleeves and support all aspects of discovery research in advancing our proprietary LNP platform. You have a team player mentality and excellent communication skills that will allow you to collaborate effectively as you work alongside your team, as well as cross-functionally within the organization. Your ability and desire to thrive in a nimble, fast-paced results-driven environment will set you up for success.
The Opportunity
In this fast-paced interdisciplinary role you will lead our efforts in the design, execution, and characterization of novel and existing lipid nanoparticle formulations to help advance our non-viral delivery platform and support the development of new modalities in the immuno-oncology and gene-editing space. To accomplish this, you will be responsible for analytical assays, biophysical characterizations as well as designing and conducting key experiments to evaluate and optimize our nanoparticle formulations internally as well as in collaboration with cross-functional teams.
Responsibilities
