- Provide technical leadership towards design and synthesis of new chemical entities and custom lipid components aimed at the development of our ctLNP drug product platform
- Act as a chemistry subject matter expert within the delivery department, and apply those towards advancement of our platform
- Manage and take ownership of external technical interfaces to contract research organizations (CROs)
- Work closely with the Pre-clinical, Formulation, Pharmacology, and Biology teams at Generation Bio to advance our understanding of the structure activity relationship of the novel LNP components
- Formulate and characterize nanoparticle formulations using various physicochemical and in vitro characterization techniques
- Develop strategies and workflows designed to screen and optimize nanoparticle formulations based on understanding of current technical and pharmacological barriers
- Support in vivo and in vitro studies to assess the stability and delivery kinetics of LNPs
- Lead and execute initiatives that contribute to corporate and scientific priorities
- Lead responsibilities on research strategies, experimental planning, and communication to company leadership and stakeholders
- Keep clear and transferable records of experiments, update protocols, data summaries to detail development work
- Provide technical mentorship to junior scientists
- PhD degree in a life sciences discipline with a minimum of 3 years of experience or Master's with a minimum of 6 years of experience or Bachelor's with a minimum of 8 years of related experience in an industrial setting
- Experience optimizing lipid chemistry and conjugation chemistry for nucleic acid delivery is preferred
- Understanding of lipid nanoparticle formulations for gene therapy products
- Experience working in collaborative projects and in cross-functional teams
- Strong communication and organizational skills, and demonstrated ability to operate in a fast-paced environment
- Results-driven with excellent attention to details
- Proven ability to effectively plan and organize complex work activities and prioritize task completion to meet schedules and deadlines
- Proactive thinking and multitasking are essential
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Senior Scientist, Medicinal Chemistry - Cambridge, United States - Generation Bio Co.
Description
Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases.The company's non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA.
The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient.
RES has the potential to expand Generation Bio's manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.
We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.
SUMMARY:
Generation Bio is seeking a highly motivated, enthusiastic, and creative Senior Scientist to join our Formulation and Chemistry team.
As a subject matter expert, the primary responsibilities for this position will include the conceptualization, design, and development of synthetic pathways for novel LNP components for our cell targeted lipid nanoparticle (ctLNP) formulations.
In this role, the individual will integrate knowledge of chemistry, materials science, and biology to advance our non-viral gene therapies.
In addition, the successful individual will be a thought leader and participate in cross-functional teams that include scientists in the Preclinical, Process Science, Bioconjugation, Pharmacology, and Analytical Development departments.
RESPONSIBILITIES:
QUALIFICATIONS:
POSITION:
Full-Time, Exempt
EEOC Statement:
Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants.
We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
