- Lead drug design teams applying our AI design platform to facilitate rapid SAR decision-making using state-of-the art methods in medicinal chemistry and targeted protein degradation.
- Develop and implement an integrated medicinal chemistry strategy, working in concert with partners in Data Science, De Novo Discovery, Molecular and Cellular Biology, DMPK and Pharmacology to reach hit-to-lead and lead optimization goals.
- Drive progression of lead molecules to pharmacological proof-of-concept studies and development candidate nomination.
- Collaborate closely with data scientists to evolve machine learning models for acceleration of Helicon degraders platform.
- Expand our E3 ligase ligands as well as our trimerizers discover platform. Recruit both internal and external partners to generate new research ideas and initiatives.
- Set ambitious goals and aggressive timelines for reaching key discovery milestones and rapid delivery of first-in-class HeliconTM peptide drugs to patients.
- Participate in company portfolio and stage-gate reviews, lead the preparation and presentation of program advancement.
- Collaborate with Lead IP Counsel to formulate intellectual property strategies.
- Ph.D. in Chemistry with 15+ years of Industry experience in pharmaceutical/Biotech setting required.
- Demonstrated expertise and a track record of success in advancing discovery programs involving PROTAC and/or molecular glues from target validation through lead optimization and into clinical development.
- Fluency in applying computational methods to medicinal chemistry design problems.
- Innovative thinker with experience as a successful therapeutic program team (co)leader.
- Solid understanding of cellular/molecular biology, biochemistry, biophysics, mechanisms of drug metabolism, pharmacokinetic and pharmacodynamic sciences.
- Ability to motivate team and find creative solutions to problems. Demonstrated influence, negotiation, and conflict resolution skills.
- Capacity to execute tasks independently to achieve company goals on an established timeline.
- Excellent communication, organization, multi-tasking, flexibility, and team skills.
- Enthusiasm to work in a dynamic research environment.
- Able to work on-site and attend in-person meetings.
- Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
- Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
- Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
- Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.
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Senior Director, Medicinal Chemistry - Cambridge, United States - FogPharma
Description
Job Description
Job DescriptionWhy Join Us?
FogPharmaTM is a clinical-stage biopharmaceutical company that seamlessly integrates breakthroughs in bench science and data science to create transformative precision therapeutics for patients suffering from devastating and often fatal diseases such as cancer. FogPharma' s discovery engine creates HeliconTM therapeutics, which are a new generation of ultra-diverse, highly tunable peptide drugs capable of modulating virtually any protein implicated in disease. Our robust and wholly owned pipeline of programs is currently focused on cancer targets that are intractable to small molecules and biotherapeutics.
The company's lead program, FOG-001, is a long sought-after blocker of β-catenin:TCF interactions that is currently being evaluated in a Phase 1/2 clinical trial in patients with Wnt/β-catenin signaling pathway-activated solid tumors, including colorectal cancer. FogPharma has raised more than $350 million to date from top investors and is led by an experienced team of industry experts. FogPharma is headquartered in Cambridge, MA.
What's the opportunity?
This is an exciting opportunity to bring a transformational new modality, our Helicon degraders, to clinical development. We are seeking a creative drug designer with deep expertise in targeted protein degradation. Helicons have the ability to bind tightly to a broad range of targets that traditionally are thought to be undruggable and this provides a unique opportunity to expand the accessible drug space by incorporating degrader and molecular glue functionalities. The successful candidate will be responsible for leading the molecular design in multiple Helicon degrader programs from hit to development candidates. Specifically:
What you will need to be successful in this role:
Core Values
FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.
As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
