- Serve as the chemistry leader for multiple exploratory and hit-to-lead drug discovery programs and be capable of and willing to guide selected programs through lead optimization and candidate selection
- Design and implement medicinal chemistry strategies to achieve program, department, and corporate goals
- Design and oversee the synthesis of compounds aimed at modulating the activity of transcription factors
- Effectively communicate medicinal chemistry strategies to a diverse cross-section of colleagues
- You have a PhD degree in organic or medicinal chemistry, and at least 6-10 years of drug discovery experience in a pharmaceutical/biotechnology company, or a Masters degree in organic/medicinal chemistry and at least 10 years of experience in a pharmaceutical/biotechnology company
- You have experience interpreting and integrating biochemical, cellular, and ADME data and implementing medicinal chemistry strategies to advance chemical matter through all phases of drug discovery
- You have experience managing CRO chemistry teams
- You have experience with covalent modifiers
- You are a creative thinker and enjoy solving challenging medicinal chemistry problems
- You have a record of accomplishment in medicinal chemistry as evidenced by publications and patent applications in the field
- You have the capacity to manage ambiguity and uncertainty, within a fast growing, dynamic and risk-taking environment with resiliency, higher order multitasking skills and self-motivation.
- You have strong communication skills, both written and verbal, especially around delivering compelling scientific narratives attuned to a particular audience.
- You enjoy fostering a culture of innovation.
- You love science and have a sense of humor.
-
Director, Medicinal Chemistry
5 days ago
Sail Biomedicines Cambridge, United StatesSail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing ...
-
Director, Medicinal Chemistry
3 weeks ago
Third Harmonic Bio Cambridge, United StatesAbout Third Harmonic Bio · Third Harmonic Bio is a biopharmaceutical company with a singular purpose: To create a breakthrough treatment for people living with severe allergy and inflammation - debilitating conditions that can take a significant toll on overall health and well-b ...
-
Principal Scientist, Medicinal Chemistry
2 weeks ago
MOMA Therapeutics Cambridge, United States Full timeMOMA Therapeutics is looking for an experienced Principal Scientist, Medicinal Chemistry. · Imagine joining a company where you....Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly collaborates · Will work with ...
-
Senior Scientist, Medicinal Chemistry
1 week ago
Third Rock Ventures Cambridge, United StatesThe Opportunity: · * Does delivering a great development candidate thrill you? That's what we live for, too, and we aim to build the best environment in the industry to discover the drugs that will make a difference for patients. We are looking for a self-motivated, creative, and ...
-
Director, Medicinal Chemistry
3 weeks ago
Third Harmonic Bio Cambridge, United StatesThe Role · Third Harmonic Bio is seeking a Director, Medicinal Chemistry to join us in our aim to become a leading small molecule company in the inflammation and immunology space. The successful candidate will partner with the VP, Medicinal Chemistry, support and execute on the ...
-
Lilly Boston, United StatesAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
-
Lilly Boston, United StatesAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
-
Senior Director, Medicinal Chemistry
2 weeks ago
Fog pharma Cambridge, MA, United StatesWhy Join Us?FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma i ...
-
Novartis AG Cambridge, United StatesAbout the Role · Internal Role Title: AD and Senior Principal Scientist, Data Science · Location: Cambridge, MA · About this role: · Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse talents to redefine the way ...
-
AstraZeneca, plc Watertown, United StatesLocation: Waltham, MA, US - Do you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines. Our pioneering oncology pipeline enabled by transform Chemistry, Oncology, Scientis ...
-
AstraZeneca Waltham, United StatesJob Description · Associate Director, Medicinal Chemistry, TTD, Early Oncology · Location: Waltham, MA, US · Do you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines. Ou ...
-
AstraZeneca Waltham, MA, United StatesAssociate Director, Medicinal Chemistry, TTD, Early OncologyLocation: Waltham, MA, USDo you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines. Our pioneering oncology pi ...
-
ERS Chemistry Sourcing Lead
3 weeks ago
Pfizer Cambridge, United States Full timeWhy Patients Need You · Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Wh ...
-
Open Call
5 days ago
Flagship Pioneering Cambridge, United StatesCompany Overview: · Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of a transformational new class of medicines that is unlocked by novel synthetic and computational ...
-
Director of Drug Substance Manufacturing
4 weeks ago
QurAlis Cambridge, United StatesABOUT THE COMPANY · At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic l ...
-
Flagship Pioneering Cambridge, United States Full timeWhat if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? · Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on con ...
-
Research And Development Scientist
1 week ago
GForce Life Sciences Cambridge, United StatesAssociate Scientist · Duration: 6-month contract · Location: Cambridge, MA · Description: · We are looking for a highly motivated Associate Scientist to join our small molecule structural biology and biophysics efforts within our department of Biotherapeutic and Medicinal Scien ...
-
Biogen Cambridge, United States Full timeJob Description · About This Role · Biogen is seeking a highly motivated and experienced scientist to join the Pharmaceutical Sciences team within Small Molecule Drug Product Development to advance preclinical assets into clinical development and beyond to commercialization. The ...
-
Senior Scientist, Discovery Biology
3 weeks ago
Flagship Pioneering Cambridge, United StatesWhat if... you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? · FL94 Inc., is a privately held, early-stage biotechnology company pioneering Protei ...
-
Head of Drug Substance/CMC Lead
3 days ago
Cellarity Somerville, United StatesWhat if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way? · What this position is all about: Cellarity is seeking a highly motivated and innovative Director/Senio ...
Director/Senior Director, Medicinal Chemistry - Cambridge, United States - Flare Therapeutics
Description
Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines.
Based on insights from the seminal work of its scientific founders, Flare's team has uncovered 'switch sites,' druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease.
Flare's drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.
We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients.
In this role you will...
Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe.
Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.TO ALL AGENCIES:
Please, no phone calls or emails to any employee of Flare Therapeutics about our openings.
All resumes submitted by search firms/employment agencies to any employee at Flare Therapeutics via email, the internet or in any form and/or method will be deemed the sole property of Flare Therapeutics, unless such search firms/employment agencies were engaged by Flare Therapeutics for this position and a valid agreement with Flare Therapeutics is in place.
In the event a candidate who was submitted outside of the Flare Therapeutics agency engagement process is hired, no fee or payment of any kind will be paid.
