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    Sr. Scientist/Principal Scientist– Protein Sciences - Boston, United States - Third Rock Ventures

    Third Rock Ventures
    Third Rock Ventures Boston, United States

    1 week ago

    Default job background
    Pharmaceutical / Bio-tech
    Description

    Sr. Scientist/Principal Scientist– Protein Biochemist

    A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of biochemical and biophysical assays, crucial in advancing the company's Discovery pipeline. We are looking for an individual with outstanding communication and collaboration abilities, who excels in cross-functional, multi-disciplinary drug discovery teams. Additionally, experience in managing direct reports and coordinating with external CROs is highly valued.

    Key Responsibilities:

    · Contribute to the overall scientific strategy and build out of the Discovery Biologics group

    · Design and execute a wide range of biochemical and biophysical assays for screening and characterizing protein-protein and protein-ligand interactions

    · Conduct stability and developability studies on biologics to inform lead candidate selection

    · Utilize structural, sequence, and computational tools to design protein constructs

    · Skillfully label and characterize protein reagents using biotin/fluorophores

    · Oversee external research at CROs, managing activities, assay development, and facilitating seamless data and reagent transfers internally

    · Proactively assess and integrate new screening technologies into the drug discovery process

    · Proficiently express and purify antibodies and novel biologics utilizing standard techniques

    · Develop and execute project plans, coordinating workflows and logistics to achieve project milestones

    · Effectively present research findings at internal meetings and external scientific conferences

    Candidate Requirements:

    · Ph.D. in Biochemistry, Biophysics, Structural Biology, or related field or B.Sc./M.Sc. with 2+ years of relevant experience in the Biotech Industry.

    · Essential expertise in SPR (BIAcore) and proficiency in utilizing other biophysical techniques (BLI, ITC, FP, DLS) for characterizing protein-protein interactions

    · Proficiency in structural biology and computational tools to aid in designing of protein constructs

    · Strong grasp of biochemical methods for protein purification, including affinity, IEX, SEC, HIC, and MMC

    · Embraces new challenges and thrives in a dynamic, start-up environment

    · Demonstrates a strong work ethic and high motivation

    · Capable of working both independently and collaboratively within a team to meet deadlines and contribute to strategic company objectives

    · Excellent written and verbal communication skills

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