Senior Research Associate, Analytical R&D - Boston, United States - Verve Therapeutics, Inc.

Description

Job Description

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.

Verve is seeking a highly accomplished Sr. Research Associate within the Analytical Research & Development team, to support biophysical characterization of lipid nanoparticles as well as gRNA and mRNA.

The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery, process development, CMC, and internal quality control groups.

• Develop, optimize and execute biophysical methods intended for a variety of purposes, including research support, stability testing, and high throughput analysis.
• Develop sample preparation procedures to increase robustness of biophysical methods.
• Utilize strong understanding of biophysics to improve upon existing methods. Where appropriate, apply DOE methodology to further optimize analytical methods.
• Review, interpret, and present data within the analytical team and cross-functionally.
• Assist in writing, reviewing, revising technical source documents.
• Work collaboratively with other R&D team members to accomplish project goals and milestones.
• Train and mentor junior team members.
• Other duties as assigned.

• B.S. degree Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences field.
• 3+ years of relevant experience required.
• Demonstrated experience using, developing, and troubleshooting analytical methods applied to understand complex and heterogenous systems (e.g. Static/Dynamic Light Scattering, SEC-MALS, Asymmetric Field Flow Fractionation coupled with MALS (AF4-MALS), Nanoparticle Tracking Analysis (NTA), and nanoparticle flow cytometry).
• Previous experience developing calorimetric and light scattering methods for proteins, gRNA, mRNA, and LNP is required.
• A deep understanding of Biolayer Interferometry and demonstrated experience in developing and deploying BLI methods within the context of enzyme/RNA interactions.
• Advanced competence in operating and troubleshooting HPLC/UPLC coupled with multiangle light scattering (MALS).
• Strong background in biophysics, with knowledge of physical chemistry applied to nucleic acids. Solid understanding of light scattering fundamentals.
• Must be highly motivated with high quality standards for one's own work
• Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
• Comfortable communicating highly technical information.
• Attention to detail, critical analysis of data/reports, and troubleshooting abilities.

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.