Scientist, Library Screening - Cambridge, United States - Moderna, Inc.

Moderna, Inc. Cambridge, United States

1 week ago

Description

The Role:

The successful candidate will partner with a multidisciplinary team to develop internal capabilities and perform screens to discover and characterize antigen variants with improved surface expression and thermal stability. The goal is to use library construction and verification coupled with mammalian display to enable campaigns for multiple targets of interest. Successful lead generation will allow for subsequent testing in pre-clinical models and subsequently in the clinic. The position offers significant scientific growth opportunities in several areas including vaccine development, infectious disease biology, protein engineering and automation.

Responsibilities:

You will work in close collaboration with research leadership and a team of peers to identify and prioritize targets for screening. Success will require a collaborative and proactive approach with a clear focus on effective team work. Excellent laboratory and organizational skills combined with insightful and decisive data analysis will be required to ensure that program team deadlines are consistently reached. Presentation in program team and departmental meetings will be required to communicate results and recommendations to stakeholders. Further responsibilities include report and protocol writing, reagent generation and archiving, equipment onboarding, inventory maintenance and data archiving (ELN/LIMS).

Skill Set:

Experience with both library screening and mammalian display are essential and ideally include: molecular biology methods for multiple library generation strategies (including key PCR methods for library construction in addition to rigorous cloning methods for efficient vector library assembly and verification, familiar with random mutagenesis and DNA extraction technique), lentivirus production and transduction, mammalian cell culture, FACS and NGS sequencing methods and associated data analysis techniques. Additional skills to support downstream characterization as needed would be beneficial and could include: protein expression and purification using FPLC systems and biophysical characterization methods (SEC-MALS, DSF, and biosensor techniques including BLI and SPR.

Here's What You'll Do:

Collaborate with bioinformatics team to translate library design concepts into experimental strategy with associated timelines.
Collaborate with wet lab team members to further develop screening strategy and assign responsibilities to ensure timely progress balanced with other activities.
Perform library generation and cloning, perform cell staining, use FACS to isolate clones with improved expression, prepare DNA samples for NGS, coordinate with NGS team to acquire and analyze data, archive all data in accessible formats.
Collaborate with manager to integrate experimental design and outcomes for presentation to team and program members, make recommendations based on data and program team feedback.
Utilize an ELN to capture experimental results and participate in LIMS integration.
Assist in reagent ordering and inventory in addition to procurement and maintenance of laboratory equipment.

Here's What You'll Bring to the Table:

Exceptional Ph.D. in immunology, bacteriology, virology, molecular biology, biochemistry or biophysics ideally with industry experience.
Outstanding laboratory experience and knowledge in various library construction and screening workflows, experimental design, data analysis and ability to transition hypotheses into data and scientific insights.
Knowledge of mRNA biotechnology, bacteriology, virology, immunology, protein structure and vaccine design is a plus.
Candidates will be curious in exploring new paths for drug discovery, bold in proposing creative experimental designs and ideas, will work collaboratively with multifunctional teams and be relentless in pursuing successful outcomes.
Candidates must possess excellent data management and verbal/written communication skills, have excellent track record in experimental performance, evaluate and process data, present results in a clear, concise and timely manner, and assist with the preparation of final written reports.
Ability to work independently and as part of a team in a highly dynamic, fast-paced, matrixed environment with evolving priorities.
Ability to collaborate with colleagues to achieve scientific and career goals aligned with business objectives.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:

• Vacation, sick time and holidays

• Volunteer time to participate within your community

• Discretionary year-end shutdown

• Paid sabbatical after 5 years; every 3 years thereafter
Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit to learn more about our current opportunities.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We're focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at (EEO/AAP Employer)
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