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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director
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Associate Director - San Francisco, United States - BioPhase
Description
Associate Director$170-200K + bonus & equityResponsibilities:
As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology
Key responsibilities include:
Designing and executing in vitro and ex vivo studies to advance therapeutic programs.
Generating, analyzing, and interpreting complex data to establish functional PK/PD and efficacy relationships, elucidating the therapeutic mechanism of action for lead drugs.
Serving as the Disease Biology lead on multiple project teams, conducting and troubleshooting experiments, and collaborating cross-functionally to identify and mitigate risks for effective program advancement.
Contributing to the development of complex in vitro and ex vivo research and development capabilities.Authoring and reviewing protocols, study reports, and regulatory documents to facilitate IND and other regulatory filings.
Following all company policies/practices and maintaining accurate records and notebooks.
Required Qualifications:
PhD in Endocrinology, Physiology, Diabetes/Obesity, Immunology/Inflammation, or a related biological science (MS with relevant years of experience).At least 8 years of direct hands-on experience in therapeutic development leveraging indication-specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 12 years).Hands-on experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g., IF/IHC/ISH), and/or flow cytometry.
Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays.Proven ability to collaborate in writing protocols, reports, and regulatory documents.
Outstanding communication skills with a demonstrated ability to make effective presentations.
Experience with therapeutics programs that have yielded drugs entering clinical development in areas such as endocrinology, diabetes/obesity, immunology/inflammation, or metabolic disease.
Familiarity with microscopy, confocal imaging, or similar techniques.Experience working as a subject matter expert with complex cell-based 2D/3D culture systems or ex vivo tissue models or patient-derived samples.
Ability to generate, analyze, and interpret multi-omic data sets.Proficiency in establishing workflows, using Jupyter notebook or other platforms for bioinformatics analysis, and interpreting/visualizing complex data sets.
Previous experience leading a program in therapeutic discovery/development.
Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results.
Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams.
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