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    Associate Scientist - Waltham, MA, United States - AstraZeneca

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    Description
    Associate Principal Scientist, Medicinal Chemistry, TTD, Early Oncology

    Do you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines.

    Our pioneering oncology pipeline enabled by transformative technologies drives us forward. AstraZeneca is a global, innovation-driven, integrated biopharmaceutical company.

    Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add new value for society.

    Oncology is a core therapy area and growth platform at AstraZeneca and our vision is to deliver life-changing medicines that improve outcomes for patients most in need.

    The newly hired Associate Principal Scientist will contribute to and influence small molecule ligand discovery within the tumor targeted delivery (TTD) chemistry group.

    Devise and implement medicinal chemistry strategies that enable the discovery of novel, differentiated small molecule candidates for tumor targeted delivery programs
    Analyze structural, pharmacological, physicochemical and ADMET data to derive SAR
    Apply expertise and know-how of modern medicinal chemistry principles to generate innovative new target designs and drive programs to achieve milestones
    Work with computational chemistry colleagues to develop hypothesis driven solutions to overcome medicinal chemistry challenges
    Set clear priorities and leverage CRO resources to prepare target molecules in a timely manner
    Design and execute synthetic routes to target molecules
    Act as a role model and mentor for medicinal chemistry colleagues
    Exhibit leadership and team player behaviors, collaborating with colleagues from diverse drug discovery functions
    Participate in program team meetings, and prepare written project updates and presentations for TTD leadership
    Take a lead role in writing patent applications, peer-reviewed articles, and abstracts for scientific conferences
    ~ focused on synthetic organic chemistry or medicinal chemistry with 3+ years of experience in biotech and/or pharmaceutical industry setting ( OR M.Sc. degree focused in synthetic organic chemistry with 8+ years of experience), and a strong track record of scientific innovation and success documented through peer-reviewed publications and patents

    Subject matter expert in organic synthesis and methodology, with general knowledge of the mechanisms of chemical reactivity and awareness of latest scientific literature.

    Experience in small molecule drug discovery with track record of excellence in achieving program milestones
    Strong work ethic and adherence to safe practices in the laboratory

    The Waltham R&D site is home to our small-molecule oncology research in North America. It is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech start-ups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.

    The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region.

    It is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies.

    The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients.

    Plenty of free covered/uncovered parking is available along with charging stations for electric vehicles. Additionally, shuttle service to local transportation hubs is also available.

    As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026.

    Why AstraZeneca?

    At AstraZeneca, we are dedicated to being a Great Place to Work . A place where employees are empowered to push the boundaries of science and unleash their entrepreneurial spirit. An inclusive culture that champions diversity and collaboration.

    Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline.

    In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

    AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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