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    Research Scientist in Chemical Biology - San Francisco, CA, United States - General Proximity

    General Proximity
    General Proximity San Francisco, CA, United States

    2 weeks ago

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    Description
    Principal Scientist, Medicinal Chemistry
    General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines.

    Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

    We are seeking first-rate M edicinal Chemists with clinical experience, preferably with previous experience developing PROTACs or related CIDs, to help us pioneer this uncharted frontier of drug discovery.

    A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem.

    Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2 , 3 , 4 ], and our technology holds the same promise.

    We are seeking an experienced Medicinal Chemist to be a founding member of our Platform/Drug Discovery Team.

    In this position you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.


    Your responsibilities will include:

    supervising synthetic efforts with our CROs, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

    Drug discovery is doubly so. PhD in Chemistry, Medicinal Chemistry, Chemical Biology, Pharmacology, or related field
    ~Deep understanding of small-molecule drug discovery and its relationship to human disease:
    ~ PROTACs) or molecular glues
    ~ Experience in people and project management
    ~ Prior experience on teams that have successfully advanced research to the clinic

    Computational or Molecular dynamics drug discovery experience.

    We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.

    Top tier medical, dental, and vision coverage + One Medical membership.

    Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer.

    Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

    We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

    We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

    Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. Are you located in the Bay Area or willing to relocate?
    Do you have (or expect to have) a PhD degree in a relevant field?

    Do you have relevant industry experience in this field?

    Will you now or in the future require visa sponsorship for employment at General Proximity?
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