- PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
- Experiencing leading and managing highly effective teams in the industry.
- Deep understanding of small-molecule drug discovery and its relationship to human disease.
- Strong experience with:
- Hit finding and hit-to-lead studies
- HTS and phenotypic assay development and screening
- Small molecule binding affinity assays
- PPI techniques, e.g., BRET, APEX/BioID, AlphaScreen
- Proficiency in:
- Platform development
- Compound management
- Disease model development
- Biochemical assay development
- Nice to have:
- Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc
- Familiarity or experience with PROTAC/next-gen IPM technologies
- Biophysical screening techniques such as SPR or fluorescence anisotropy
- DEL experience
- Experience with med-chem optimizations: SAR, PK/PD, etc
- Computational drug discovery experience
- Prior experience on teams that have successfully advanced research to the clinic
- Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
- Top tier medical, dental, and vision coverage + One Medical membership.
- 401(k) retirement plans.
- Education and health/fitness incentive programs.
- Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
- Reading budget We will buy you books.
- Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.
-
Research Associate, Drug Discovery
4 days ago
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
-
Senior Veterinary Assistant, Emergency
5 days ago
Ethos Veterinary Health San Francisco, United States· RVT or Senior Veterinary Assistant- ER - Swing Shift Fri-Mon - SAGE San Francisco · Who we are: · SAGE San Francisco holds a deep appreciation for animals, fueled by sincere love and admiration for their extraordinary nature. · We form a community of experienced, board-certifi ...
-
Senior Veterinary Assistant, Emergency
3 weeks ago
Ethos Veterinary Health San Francisco, United States· RVT or Senior Veterinary Assistant- ER - Swing Shift Fri-Mon - SAGE San Francisco · Who we are: · SAGE San Francisco holds a deep appreciation for animals, fueled by sincere love and admiration for their extraordinary nature. · We form a community of experienced, board-certifi ...
-
Senior Veterinary Assistant, Emergency
6 days ago
Ethos Veterinary Health SoMa, United States· RVT or Senior Veterinary Assistant- ER - Swing Shift Fri-Mon - SAGE San Francisco · Who we are: · SAGE San Francisco holds a deep appreciation for animals, fueled by sincere love and admiration for their extraordinary nature. · We form a community of experienced, board-certifi ...
-
Senior Veterinary Assistant, Emergency
3 weeks ago
Ethos Veterinary Health SoMa, United StatesRVT or Senior Veterinary Assistant- ER - Swing Shift Fri-Mon - SAGE San Francisco · Who we are: · SAGE San Francisco holds a deep appreciation for animals, fueled by sincere love and admiration for their extraordinary nature. · We form a community of experienced, board-certified ...
-
Research Associate, Drug Discovery
2 weeks ago
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
-
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
-
Research Scientist Director
4 weeks ago
Generalproximity San Francisco, CA, United StatesGeneral Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other m ...
-
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable t ...
-
Principal Scientist/Director, Chemical Biology
9 hours ago
The University of Texas MD Anderson Cancer Center San Francisco, United StatesJob Title: Principal Scientist/Director, Chemical Biology · Job Number: · 78085 · Location: · San Francisco, CA,US · Job Description · tl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discover ...
-
Research Associate, Drug Discovery
2 weeks ago
The University of Texas MD Anderson Cancer Center San Francisco, United StatesJob Title: Research Associate, Drug Discovery · Job Number: · 77686 · Location: · San Francisco, CA,US · Job Description · TL;DR · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine fur ...
-
Research Scientist Director
4 weeks ago
The University of Texas MD Anderson Cancer Center San Francisco, CA, United StatesPrincipal Scientist/Director, Chemical Biology · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challen ...
-
Staff Mechanical Design Engineer
2 days ago
GE Aviation San Francisco, United States PermanentJob Description Summary Are you ready to elevate your future? At GE Aerospace, we are advancing aviation technologies for today and tomorrow. Your work will contribute to the production of advanced jet engines, components, and integrated systems that power commercial and military ...
-
Research Associate
23 hours ago
Gladstone Institutes San Francisco, United States Full timeCategory:Science · Lab/Area:Bruneau LabDescription: · Research Associate – Bruneau Lab · Who we are: · The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and e ...
-
Research Associate
2 weeks ago
BioSpace San Francisco, United StatesJob Details · Category:Science · Lab/Area:Bruneau Lab · Description: · Research Associate - Bruneau Lab · Who we are: · The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medic ...
-
Senior Veterinary Assistant, Emergency
3 days ago
Ethos Veterinary Health San Francisco, United StatesJob Description · RVT or Senior Veterinary Assistant- ER - Swing Shift Fri-Mon - SAGE San Francisco · Who we are: · SAGE San Francisco holds a deep appreciation for animals, fueled by sincere love and admiration for their extraordinary nature. · We form a community of experienced ...
-
University of California , San Francisco San Francisco, United StatesApplication Window · Open date: February 26, 2024 · Most recent review date: Tuesday, Mar 12, 2024 at 11:59pm (Pacific Time) · Applications received after this date will be reviewed by the search committee if the position has not yet been filled. · Final date: Tuesday, Aug 26, 20 ...
-
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
-
Principal Scientist/Director, Chemical Biology
3 weeks ago
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
-
Scientist/Sr. Scientist, Lead Discovery
3 weeks ago
General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
Principal Scientist/Director, Chemical Biology General Proximity The next generation of induced - San Francisco, CA, United States - MBC BioLabs
Description
tl;dr
General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking first-rate chemical biologiststo help us pioneer this uncharted frontier of drug discovery.
Our Story
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2 , 3 , 4], and our technology holds the same promise.
The Position
We are seeking an experienced chemical biologist to be a founding member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
Your responsibilities will include supervising synthetic efforts with our CROs, designing and performing both low and high-throughput screening assays, managing compound libraries, performing mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.
About You
High Agency. Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.
Qualifications & Nice-To-Haves
Benefits
About Us
Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off.
Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you.
More info at
#J-18808-Ljbffr
