Research Scientist Director - San Francisco, CA, United States - Generalproximity

Description

General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines.

Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking first-rate chemical biologists to help us pioneer this uncharted frontier of drug discovery.
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem.

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2 , 3 , 4], and our technology holds the same promise.

We are seeking an experienced chemical biologist to be a founding member of our Platform/Drug Discovery Team.

In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include supervising synthetic efforts with our CROs, designing and performing both low and high-throughput screening assays, managing compound libraries, performing mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

Drug discovery is doubly so. PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
Experiencing leading and managing highly effective teams in the industry.
Deep understanding of small-molecule drug discovery and its relationship to human disease.
PPI techniques, e.g., Platform development
Compound management
PTM analysis, chemo-proteomic target deconvolution, etc
Computational drug discovery experience
Prior experience on teams that have successfully advanced research to the clinic

We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.

~ Top tier medical, dental, and vision coverage + One Medical membership.
~401(k) retirement plans.
~ Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed.