Jobs
>
New York City

    Scientist - New York, United States - Lime Therapeutics

    Lime Therapeutics
    Lime Therapeutics New York, United States

    1 day ago

    Default job background
    Pharmaceutical / Bio-tech
    Description

    POSITION: PhD Scientist – Target Validation and Translational Drug Discovery

    Lime Therapeutics is a platform-enabled seed-stage biotechnology startup developing medicines targeting altered lipid-mediated pathways in patients with cancer, metabolic diseases, and aging-related neurodegenerative disorders. We are a VC-backed spinout from Memorial Sloan Kettering Cancer Center, using our breakthrough LipidSenseTM platform to identify small molecules which inhibit novel disease-specific lipid processing targets. Our vision at Lime is to leverage our technology and expertise in lipid biology to bring our own first-in-class therapeutics to patients.

    We are building an environment where highly motivated scientists looking to make an immediate difference can learn broadly, think independently, and work fast to drive our pipeline programs forward. Lime is headquartered at BioLabs NYU, a vibrant state-of-the-art accelerator with over 40 Seed and Series A biotech companies, in the heart of New York City's SoHo neighborhood.

    Mission

    Lime has identified novel in vivo essential targets that will lead to first-in-class medicines for patients with KRAS-mutant non-small cell lung cancer (NSCLC). The mission of this role is to progress these hits from target prioritization and validation to small molecule development. In this role, you will independently validate and characterize tumor progression in genetic cell models in vivo and develop a deep understanding of the targets' mechanism of action in vitro and in vivo. As part of our team, you will effectively leverage our network of consultants, advisors, and CROs to successfully progress 3 targets into the next phase of clinical development.

    What you will do in this position

    Nominate a list of up to 3 targets for inclusion in Lime's development pipeline within 6-8 months

    ● Generate and validate (by WB or qRT-PCR, etc.) CRISPR KO (stable or inducible) and appropriate control cells for 5-10 shortlisted targets within 3-4 months

    ● Perform in vivo tumor experiments with generated cell lines within 6-8 months

    ● Design experiments with proper controls, appropriate mouse/tumor models, and defined endpoints and measurements for target validation experiments in vivo

    ● Understanding the MoA of the targets to advance program to lead discovery and optimization

    Requirements for this position

    ● PhD in biological or biomedical science with a focus on cancer

    ● Track record of independently delivering scientific results

    ● Motivation and desire to be a pivotal member of a growing seed-stage startup

    Skills for this position

    You will be a great fit for this role if you have:

    ● Expertise in in vivo tumor models including subcutaneous injection, tail vein injection, luciferase and caliper measurements, and mouse handling and dissections

    ● Expertise in aseptic tissue culture techniques including cell line maintenance, proliferation experiments, CRISPR-Cas9 gene editing, inducible knockout, or expression systems

    ● Expertise in molecular biology techniques including cloning, Western blot, qRT-PCR, etc.

    ● Impeccable and efficient experimental design, assay development, and execution

    ● Strong scientific communication skills, perform detailed data analysis and accurate record keeping to support our IP portfolio, and can present to internal and external parties

    ● Experience managing professional relationships and can communicate with a range of stakeholders, including consultants, advisors, and CROs

    Culture at Lime

    You will thrive as our teammate if you:

    ● Are independent and creative with a proven track record of scientific leadership and success

    ● Have strong interpersonal communication skills, including as a representative of Lime

    ● Consistently follow through on commitments by taking responsibility for outcomes

    ● Have a strong willingness to work hard to get the job done

    ● Engage in honest and open two-way communication to actively foster a collaborative environment

    ● Are mission driven, think strategically with the big picture in mind, and align with and commit to the team's goals

    ● Can rationally adapt and pivot based on the data to achieve team milestones

    Salary and Benefits

    The salary range for this fully in-person full-time position is $100,000-$130,000 commensurate with skills and experience. As an early employee, you will be offered stock options with significant potential upside. In addition, Lime is committed to the well-being of our team members and offers a comprehensive benefits package.

    At Lime Therapeutics equality, diversity, and inclusion are incredibly important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion, belief, or marital or civil partnership status.

  • NYC Careers

    Data Scientist

    3 hours ago

    NYC Careers Manhattan, United States

    **DATA SCIENTIST**: · - Apply**DATA SCIENTIST**: · - Agency: CAMPAIGN FINANCE BOARD · - Posted on: 05/16/2024- Job type: Full-time · Location · MANHATTAN · - Title Classification: No exam required · Department · Managerial · - Salary range: $75, $90, The New York City Campaign Fi ...

  • REFORM Alliance

    Data Scientist

    2 hours ago

    REFORM Alliance New York, United States

    **Data Scientist** · **LOCATION: New York or Washington, D.C. (Hybrid)** · **Reports to**:Senior Director of Implementation · **About REFORM Alliance**: · REFORM is committed to transforming probation and parole throughout the United States by changing laws, systems, and culture. ...

  • Spotify

    Data Scientist

    3 days ago

    Spotify New York, United States

    Data Science- We are looking for a seasoned data scientist with experience providing insights to platform organizations to join the Personalization Platform team. The Personalization Platform team builds the models, tools, and data products that represent user taste, behavior, di ...

  • Messenger

    Data Scientist,

    3 hours ago

    Messenger New York, United States

    **Data Scientist, Messenger Responsibilities**: · - Work with large and complex data sets to solve a wide array of challenging problems using different analytical and statistical approaches. · - Identify and measure success of product efforts through goal setting, forecasting, an ...

  • BlueRock Therapeutics

    Scientist Ii

    6 days ago

    BlueRock Therapeutics New York, United States

    **Who is BlueRock?** · BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique **_cell+gene_** platform to direct cellular differentiation and genetically engineer cells to create a new ...

  • Hydro Tech Environmental Engineering and Geology, DPC

    Environmental Scientist

    3 days ago

    Hydro Tech Environmental Engineering and Geology, DPC New York, United States

    HydroTech is hiring an environmental scientist/engineer in its NYC office to support field and office project related work. Help with preparation of Phase I ESA reports, work plans, conduct soil, water and vapor sampling, and do field remedial oversight and community air monitori ...

  • Flex

    Data Scientist

    2 days ago

    Flex New York, United States

    Flex is a growth-stage, NYC headquartered FinTech company that is creating the best rent payment experience. It's hard to believe that it's 2024 and paying rent on time is expensive, inflexible, and difficult. We're here to change that Flex enables our users to pay rent throughou ...

  • US Federal Aviation Administration

    Computer Scientist

    5 days ago

    US Federal Aviation Administration Atlantic City, United States

    **Duties**: · Serves as a Computer Scientist within the Laboratory Services Division, Simulation Branch, Target Generation Facility (TGF) Section ANG-E161. Determines technical requirements for meeting the mission needs of TGF. Meets with customers for project technical requireme ...

  • Integrated DNA Technologies (IDT)

    Applications Scientist

    6 days ago

    Integrated DNA Technologies (IDT) New York, United States

    IDT is one of 10 Life Sciences companies of Danaher. Together, we accelerate the discovery, development and delivery of solutions that safeguard and improve human health. · This position is part of the **_Scientific Applications Support team_** located in the **_United States of ...

  • KCI Technologies Inc.

    Scientist in Training

    1 day ago

    KCI Technologies Inc. Newark, United States

    Overview: · **_ · Join us as we Rise to the Challenge_** · At KCI, we're building an enduring community that provides unparalleled value to our employee-owners. We make our mark designing and delivering our world-class solutions, so we invest deeply in supporting and developing o ...

  • NBCUniversal

    Principal Data Scientist

    1 day ago

    NBCUniversal New York, United States

    **Company Description** · We create world-class content, which we distribute across our portfolio of film, television, and streaming, and bring to life through our theme parks and consumer experiences. We own and operate leading entertainment and news brands, including NBC, NBC N ...

  • NYU Stern

    Junior Research Scientist

    2 days ago

    NYU Stern New York, United States

    The NYU Stern Marketing Department seeks a highly skilled and motivated individual for a full-time Junior Research Scientist position for a period of one year. · The _**Junior Research Scientist**_ will work with faculty members at_ **NYU Stern's Marketing Department**_. The rese ...

  • New York State Psychiatry Institute

    Research Scientist I

    1 week ago

    New York State Psychiatry Institute New York, United States

    **Job Title**: Research Scientist I · **Grade**: 18 · **Salary**: $64,928 - $78,102 · The Research Foundation for Mental Hygiene is seeking a qualified applicant to fill a full-time Research Scientist I position at the New York State Psychiatric Institute. · **Duties and Responsi ...

  • TAGHLEEF INDUSTRIES

    R&d Scientist

    3 days ago

    TAGHLEEF INDUSTRIES Newark, United States

    For more than 15 years, Taghleef Industries, Inc. has built a reputation as one of the world's largest and most recognized industry leaders in specialty BOPP (Biaxially Oriented Polypropylene) films. · **Research & Development Scientist - North America** · The R&D Scientist is re ...

  • Alger

    Information Research Scientist

    1 week ago

    Alger New York, United States

    **Job Title**:Information Research Scientist · **Location**: New York, New York · **Reporting To**:VP, Senior Solutions Architect · **Duties and Responsibilities**: · - Consulting with stakeholders to determine needs/weaknesses · - Designing experiments to test and improve system ...

  • Biolog

    Lab Dna Scientist

    1 week ago

    Biolog Newark, United States

    : · **Who Are We?** · Biolog Lab Services founded the DNA sequencing method for microbial identification and has, for over two decades, delivered critical, time-sensitive ID for pharmaceutical, probiotic, food and beverage, and personal care manufacturing customers. At our Newark ...

  • Captions

    Applied Scientist, Avatars

    1 week ago

    Captions New York, United States

    Captions is the AI-powered creative studio. Millions of creators around the world have used Captions to make their video content stand out from the pack and we're on a mission to empower the next billion. · Based in NYC, we are a team of ambitious, experienced, and devoted engine ...

  • WellSpan Health Services

    Nursing Research Scientist

    1 week ago

    WellSpan Health Services York, United States

    **General Summary** · Consults, plans, coordinates, and collaborates in the design and completion of RN-led Evidence Based Practice (EBP) projects and research studies, performing scientific tasks and related activities. Performs a variety of scientific services related to litera ...

  • Walmart

    Principal, Data Scientist

    1 day ago

    Walmart Hoboken, United States

    Position Summary... · What you'll do... · As the **Principal Data Scientist, Marketing Data Science **, you will lead the development of world-class analytics within the Walmart US Marketing team. You and your team are responsible for providing insights about retail and product m ...

  • Spotify

    Data Scientist, Financial Data

    1 week ago

    Spotify New York, United States

    Data Science- We are looking for a Data Scientist to join our Legal Analytics team within the Finance Data & Insights organization. Your responsibility will be to support the Legal, Finance, and Accounting organizations through data analytics, process automation, technical guidan ...