- Hands-on development and optimization of chromatography-, capillary-, and spectroscopy-based analytical methods to be used for product release, stability, and early CMC support across multiple early-stage programs
- Work with CDMOs and internal stakeholders to develop appropriate methodologies, including stability indicating methods, to support release and stability testing of development candidates for non-clinical and clinical studies
- Manage the transfer and/or validation of analytical methods to CDMOs and independent contract testing laboratories
- Quantitative LC-UV analysis of RNA molecules pre- and post-formulation of lipid nanoparticles (LNP)
- Characterization of synthetic oligonucleotide impurities of sgRNA molecules by ion-pairing reverse-phase (IP-RP) LC-MS to support development of CRISPR therapeutics
- Method development and qualification of 5'-capping and 3'-poly A tail mRNA characterization assays by IP-RP LC-MS
- Data analysis using statistical software such as GraphPad PRISM, JMP, SoftMax Pro, etc.
- Maintain detailed records of experimental methods and data in an electronic laboratory notebook (Benching)
- Participate in authoring reports, test methods, work instructions, and tech transfer to CDMOs
- Share responsibility for basic lab management activities (ordering supplies, ensuring instruments are calibrated and maintained, making reagents)
- BS with 5+ years of experience, or MS with 3+ years of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline
- Excellent oral and written communication skills
- Effective organizational and time management skills
- Strong focus and attention to detail
- Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team
- Familiarity with CRISPR technologies and therapeutic approaches
- Familiarity with protein or RNA analytical methods
- Familiarity with FDA, ICH and EP or other regulatory agency guidance associated with analytical methods
- The ideal candidate has previous experience with tech-transfer of methods to CDMOs
-
Analytical Chemistry Intern
10 hours ago
Nurix Therapeutics San Francisco, United StatesPosition: Intern · Duration: 10 weeks · Project Description: Development and implementation of a protein binding assay in Cerebrospinal Fluid. · Manager Name: Alexandra Trotier · Department: 315 – Analytical Chemistry, In vitro ADME · Internship Job Description · We are seeking a ...
-
Product Developer
1 week ago
SilverLinx Centerville, United StatesOur renowned client in Immenstadt is currently seeking a full-time Product Developer (m/f/d) to join their team at Centerville. · AUGUSTA Personaldienstleistungen GmbH has been active in the field of personnel placement and leasing for over 30 years. Are you looking for a new cha ...
-
IDEAYA Biosciences South San Francisco, United States Full timePosition Summary: · We are seeking an experienced and highly motivated Associate Director / Director, Analytical Chemistry to join our multidisciplinary team based in South San Francisco. The role requires the candidate to work collaboratively with the related cross-functional te ...
-
IDEAYA Biosciences South San Francisco, United States Full timeIDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates ext ...
-
Principal Quality Control Specialist
3 days ago
Arsenal Biosciences Hayward, United StatesArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented Principal Quality Control Analyst to work onsite based in our Hayward office.ArsenalBio's mission is to develop efficacious ...
-
Scientist I
1 week ago
Gritstone bio Pleasanton, United States Freelance**RESPONSIBILITIES**: · - Actively contribute to the successful development, qualification and execution of robust analytical methods in support of company pipeline projects · - Perform analytical procedures in support of characterization, lot release and stability testing of dru ...
-
Environmental Chemist I/ii
3 days ago
Dublin San Ramon Services District Pleasanton, United States**Position**: · The Dublin San Ramon Services District is recruiting for a regular, full-time Environmental Chemist I/II in the Laboratory & Technical Services Division in the Operations Department. · Under direction or general supervision, learns and performs a variety of routin ...
-
Wet /analytical Chemist
3 days ago
TekWisswnGroup Sunnyvale, United States**Key Responsibilities**: · - Synthesize polymer particles using established chemistries · - Participate in process optimization, development, and scale-ups for routine production · - Perform analytical characterization of polymeric particles using specialty equipment and instrum ...
-
Scientist I
4 days ago
BOTG LLC Sunnyvale, United States**We are looking for a Scientist I - Chemistry (First-Shift) in Sunnyvale, CA for a 12+ months contract position.** · **Position: Scientist I - Chemistry (First-Shift)** · **Location: Sunnyvale, CA** · **Duration: 12+ months contract position** · **Client: Direct Client** · **Shi ...
-
Scientist I
4 days ago
TekwissenGroup Sunnyvale, United States**Key Responsibilities**: · - Synthesize polymer particles using established chemistries · - Participate in process optimization, development, and scale-ups for routine production · - Perform analytical characterization of polymeric particles using specialty equipment and instrum ...
-
Research Associate
5 days ago
Actalent Redwood City, United States Full timeDescription: · Our client is seeking an RA for our Advanced Analytical team, who will work under the direction of the Team Leader to support materials analysis of our core technology platform. The ideal candidate will have relevant experience and a track record of accomplishments ...
-
Battery Materials Scientist
3 days ago
Mitra Chem Mountain View, United StatesWe have set up a state-of-the-art 15,000 sq ft industrial R&D center in Mountain View, CA. Join our team and be a part of the growing battery revolution. · We are looking for **Battery Materials Scientists **to design, develop and scale-up production of innovative materials, leve ...
-
Research Associate, Protein Engineering
1 week ago
Stanford University Stanford, United States**SCHOOL/UNIT DESCRIPTION**: · Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The prox ...
-
Quality Assurance Specialist
5 days ago
Actalent San Mateo, United States Full timeDescription: · 20% BRR · 80% Analytical focused · • Performs a wide variety of activities to ensure compliance with applicable quality objectives and regulatory requirements · • Serves as QA Lead for clinical and commercial projects. · • Leads quality investigations/deviations/ ...
-
Research Associate, Medicinal Chemistry
1 week ago
Bayside Solutions Fremont, United StatesResearch Associate, Medicinal Chemistry · W2 Contract to Hire · Salary Range: $68,600 - $79,000 per year · Location: Redwood City, CA - Onsite Role · Job Summary: · As a Research Associate in the Medicinal Chemistry group, you will join a comprehensive, interdisciplinary research ...
-
Abdera Therapeutics South San Francisco, United States**Who we are** · Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies · - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform opt ...
-
Traveling Production Technician
1 day ago
Vertosa Oakland, United StatesFounded in 2018, Vertosa is a science-first cannabis company that creates the most effective and reliable active ingredients for infused products. Its patented and patent-pending emulsion systems are carefully designed for the specific needs of each customer, and Vertosa works cl ...
-
Research Scientist, Ai for Science
18 hours ago
Meta San Francisco, United States**Research Scientist, AI for Science Responsibilities**: · - Lead research to advance the science and technology of intelligent machines. · - Lead research that enables advances in AI applied to chemistry and material science. · - Devise better data-driven models of chemistry and ...
-
VP, Analytical Development and Quality
6 days ago
Bayside Solutions Fremont, United StatesVP, Analytical Development and Quality · Direct Hire Full-Time Role · Salary Range: $279,200 - $300,000 per year · Location: Redwood City, CA - Onsite Role · Job Summary: · As a senior leadership role within the Pharmaceutical Development and Manufacturing (PDM) organization, you ...
-
Scientist, Mass Spectrometry
1 week ago
Parvus Therapeutics South San Francisco, United States**Parvus Therapeutics Inc.** · **About Navacims** · Navacims are a novel first-in-class nanomedicine designed to treat autoimmune disease by selectively modulating disease-specific cellular responses without impairing normal immunity. Navacims specifically target and act only on ...
Sr. Research Associate I, Analytical Chemistry - Alameda, United States - Scribe Therapeutics
Description
Job Description
Job DescriptionScribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by DesignTM platform for CRISPR-based genetic medicine.
We are seeking a seeking a Senior Research Associate with experience in analytical chemistry and RNA analytics. The candidate will join the Process Sciences analytical team to help establish and implement early-stage Chemistry, Manufacturing and Controls (CMC) development and manufacturing efforts for non-viral gene editing systems for its CRISPR by DesignTM platform. Qualified candidates will have an understanding and strong knowledge of methods and techniques to characterize synthetic oligonucleotides (sgRNA) and/or mRNA using HPLC-UV, LC-MS, PAGE, capillary electrophoresis, ELISA, and other methods. The ideal candidate will have some experience building and transferring drug substance release assays to a CDMO/CRO or to Quality. We are searching for enthusiastic, creative, and highly motivated individuals comfortable working in a fast-paced entrepreneurial CMC environment.
Key Responsibilities:
Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you Visit us at
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.
At the time of posting, the base pay wage range for this role is $90,000-115,000 per year. The offered pay range will depend on internal equity and the candidate's relevant skills, experience, qualifications, training, and market data. Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.
