- Lead and manage the In Vivo Pharmacology team in performing critical preclinical efficacy studies across different clinical indications.
- Design, execution, and analysis of pharmacology studies to support the advancement of candidates along the developmental pipeline.
- Identify, initiate, and manage collaborations with CROs and academic labs as appropriate to driving projects forward.
- Provide strategic input to project teams.
- Integrate data to provide a detailed understanding of the pharmacology of therapeutic proteins to enable understanding of in vitro MOAs and in vivo correlates of efficacy.
- Establish biomarker strategies to support translational studies.
- Implement procedures for data capture and management.
- Support preparation of regulatory documents as needed.
- Maintain scientific and technical expertise through familiarity with scientific literature.
- Contribute to building a positive, team-oriented biotech culture.
- PhD in pharmacology or biological disciplines such as immunology, cellular biology, or oncology, with 8+ years direct pharmaceutical experience beyond postdoctoral work.
- In depth in vivo pharmacology experience, particularly on the design and execution of rodent disease models across broad clinical indications. Experience in hematology and autoimmune models is a plus.
- Demonstrated leadership of teams of in vivo scientists to drive go/no go decisions.
- Extensive experience in managing the design and execution of studies at CROs.
- History of translational sciences support for preclinical small molecule programs.
- Ability to manage priorities and drive multiple projects.
- Direct experience in supporting IND strategy and documentation, including writing relevant pharmacology sections of INDs.
- Excellent oral and written communication skills across all levels.
- Prior experience working in smaller companies is highly preferred.
- Passion to develop drug candidates to make an impact in patients' lives.
- Willingness to go beyond expectations to achieve critical objectives.
- Recognition of critical path activities required to succeed in drug discovery
- Push Boundaries: We create a legacy with breakthrough science in service of patients.
- Inject Energy: We build strengths from different perspectives and tell it like it is
- Own it: We transcend our job descriptions and relentlessly follow through on our commitments.
- Go all out: We work quickly and with conviction.
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Director, In Vivo Pharmacology
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BioSpace Cambridge, United StatesJob Details · The Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell mo ...
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Moderna, Inc. Cambridge, United StatesThe Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell models, and the ...
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Moderna, Inc. Cambridge, United States Full timeThe Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell models, and the ...
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Adaptimmune Cambridge, United StatesJob Description · Job DescriptionAdaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, ...
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Director, In Vivo Pharmacology - Somerville, United States - Flagship Pioneering, Inc.
Description
What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way.
What this position is all about:
Cellarity is seeking an energetic, talented and highly motivated Director/Assoc Director to lead our In Vivo Pharmacology department and play a vital role in the company's efforts to progress small molecule lead candidates to IND.
The ideal candidate must be independent, driven, open-minded, curious, goal-oriented, have excellent communication skills and work in a fast-paced entrepreneurial environment.
What you would be responsible for:
What experiences will you need:
What sets you apart:
At Cellarity, we
Company Summary:
Cellarity's mission is to fundamentally redesign the way drugs are created for the sake of bringing new hope to patients.
By shifting the focus from a single target to the underlying cellular dysfunction, we unravel the complexity of disease biology and create medicines that were never before possible.
The company has developed unique capabilities that link biology and chemistry with high dimensional -omic data from which we design medicines against the cellular signature of disease.
The Cellarity platform allows us to uncover new biology in diseases even in the absence of known causal targets. The company has drug discovery programs underway in several disease areas, including metabolic disease, hematology, and immunology.Cellarity recently completed a Series C financing, and has raised a total of $274M from all funding rounds to date, with contributions from world-renowned investors alongside Flagship Pioneering who created the company.
Cellarity's goal is to grow into a fully integrated next generation Biotech company driving a new age in drug creation.
Cellarity is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies:
Cellarity does not accept unsolicited resumes from any source other than candidates.
The submission of unsolicited resumes by recruitment or staffing agencies to Cellarity or its employees is strictly prohibited unless contacted directly by Cellarity's internal Talent Acquisition team.
Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Cellarity, and Cellarity will not owe any referral or other fees with respect thereto.
