- Carry out rodent in vivo studies adhering to IACUC standards, independently and within a team dynamic.
- Design and execute studies ranging from early exploration to IND submission stages, focusing on in vivo/ex vivo sample generation and analysis, PK/PD modeling and therapeutic efficacy.
- Performing assays to assess target engagement and biomarker analysis in samples such as blood, bone marrow, and muscle tissue, contributing to our understanding of disease mechanisms.
- Develop, optimize and conduct in vitro assays and molecular biology techniques including but not limited to RT-qPCR, ELISA, protein assay and flow cytometry.
- Demonstrate independent thought/creativity in science with excellent collaboration and communication across functional disciplines and multitasking skills.
- Maintain accurate, timely and complete electronic laboratory notebook entries.
- BS or MS with relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an academic or industry setting.
- Experience working with rodents, administering doses through various methods including but not limited to PO, IP, IV, SC and IM, and conducting post-study processes including blood draws, necropsies, and ex vivo sample analysis.
- Experience with Contract Research Organizations (CROs) is an asset.
- Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, RT-qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.
- Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.
- Proven ability to independently plan and execute experiments, analyze data, and present findings.
- A passion for contributing to a team-oriented, diverse, and inclusive work environment.
- Excellent multitasking abilities and ability to thrive in a fast-paced, collaborative setting.
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Research Associate
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Charles River Laboratories Cambridge, United States**Req ID #**:222988**Location**:Cambridge, MA, US, For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-be ...
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Forrester Cambridge, United StatesAt Forrester, we're trusted to work on trailblazing, mission critical problems that business and technology leaders face today. That's why we're always looking to empower talented individuals to perform at their best every single day. We're proud of our community of smart people ...
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TechTrueUP Cambridge, United StatesBasic Qualifications · 0+ Years w/ Relevant BS OR equivalent 2+ Years w/ Relevant AS OR equivalent 4+ Years w/ HS Foundational knowledge of technical principles, theories, and concepts to perform routine work in a role · Top 3 Must Have Skill Sets: · MUST be willing to be onsite ...
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Actalent Cambridge, United States Full timeDescription: · Independently, develop, optimize, and proactively troubleshoot cellular screening assays. · Responsible for generating, processing, interpreting, and presenting data in cross functional team meetings · Proactively employ cell and molecular biology techniques, inc ...
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Generate Biomedicines Somerville, United States**About Generate:Biomedicines** · Generate:Biomedicines is a new kind of therapeutics company - existing at the intersection of machine learning, biological engineering, and medicine - pioneering Generative Biology to create breakthrough medicines where novel therapeutics are com ...
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Point32Health Boston, United StatesWho We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
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Harvard University Boston, United States**Position Description**- **Primary Duties** · - Develop, design, conduct, analyze, and implement research using data science knowledge and prior knowledge of requested statistical packages. Perform statistical programming. · - Exercise independent decision making with regard to ...
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Laboratory Research Associate
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Day Zero Diagnostics Boston, United States**Day Zero Diagnostics (DZD)** is an exciting startup revolutionizing infectious disease diagnostics by leveraging cutting-edge sample prep technologies, whole genome sequencing and machine learning. We are building the next generation of IVDs, able to perform comprehensive bacte ...
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Associate Director, Research Finance
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MIT Cambridge, United States**ASSOCIATE DIRECTOR, RESEARCH FINANCE**, _Office of the Vice President for Research (VPR)-Research Administration Services (RAS)_, to serve as the leader for research finance, providing sponsored research financial oversight, advice, and management on behalf of MIT-wide research ...
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Contract Research Associate, in Vivo
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Orbital Therapeutics Cambridge, United States**Company Summary**: · Orbital Therapeutics aims to enhance global health by unleashing the full potential of RNA-based medicines (excluding small interfering RNA) to treat human disease in ways that were not previously possible. The company is building a first-in-kind platform a ...
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Harvard University Cambridge, United States**Job Summary** · The Program on Corporate Governance at Harvard Law School ("PCG") seeks to foster research and scholarship about corporate governance and facilitate discourse in this field among academics, practitioners, and policymakers. · The Research Associate is expected to ...
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Novartis Cambridge, United States**About the Role**: · Biomedical Research (BR) is the global pharmaceutical research organization of Novartis. With approximately 6,000 scientists and physicians around the world, our research is focused on discovering innovative new drugs that will change the practice of medicin ...
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Clinical Research Associate I
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BRIOHEALTH SOLUTIONS INC Boston, United StatesDuties and responsibilities include the following. · - Set up and maintenance of study files, including administration of the eTMF where used in clinical studies and supporting any use of CTMS · - Drafting and review of participant information sheets and informed consents · - Rev ...
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Clinical Research Associate I
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Vertex Pharmaceuticals Boston, United StatesJob Description · General Summary: · The Analytical and Purification Principal Research Associate will lead the small molecule chiral purification platform within the Medicinal Chemistry group. The individual will propose and develop improvements in the purification workflow alon ...
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Massachusetts General Hospital(MGH) Boston, United States**Clinical Research Associate Manager-Cancer Center Protocol Office** · **GENERAL SUMMARY/ OVERVIEW STATEMENT**: · The Cancer Center Protocol Office is seeking a Clinical Research Associate Manager to join our team. The Cancer Center Protocol Office is a centralized clinical rese ...
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Massachusetts General Hospital(MGH) Boston, United States**Clinical Research Associate-Cancer Center Protocol Office** · **GENERAL SUMMARY/ OVERVIEW STATEMENT**: · The Cancer Center Protocol Office is seeking motivated, detail-oriented individuals to join our team as a Clinical Research Associate. The Cancer Center Protocol Office is a ...
Sr. Research Associate - Cambridge, United States - Third Rock Ventures
Description
Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need.
Fulcrum's two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies.
The company's proprietary product engine identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.
Description
Fulcrum Therapeutics is seeking a Senior Research Associate/Associate Scientist, who will be a driven professional, eager to bolster our in vivo pharmacology research initiatives.
This role involves spearheading the design and implementation of both in vivo and ex-vivo pharmacology studies, critically contributing to our understanding of the pharmacokinetics/pharmacodynamics (PK/PD), target engagement, and therapeutic efficacy of our novel drug candidates.
As a crucial member of our multidisciplinary team, you will have the opportunity to lead and execute pre-clinical discovery studies, generating decisional data packages to support the advancement of clinical candidates.
Responsibilities
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