Sr. Research Associate - Cambridge, United States - Fulcrum Therapeutics, Inc.

Fulcrum Therapeutics, Inc. Cambridge, United States

1 week ago

Description

Company Overview

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need.

Fulcrum's two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies.

The company's proprietary product engine identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.

Description

Fulcrum Therapeutics is seeking a Senior Research Associate/Associate Scientist, who will be a driven professional, eager to bolster our in vivo pharmacology research initiatives.

This role involves spearheading the design and implementation of both in vivo and ex-vivo pharmacology studies, critically contributing to our understanding of the pharmacokinetics/pharmacodynamics (PK/PD), target engagement, and therapeutic efficacy of our novel drug candidates.

As a crucial member of our multidisciplinary team, you will have the opportunity to lead and execute pre-clinical discovery studies, generating decisional data packages to support the advancement of clinical candidates.

Responsibilities

Carry out rodent in vivo studies adhering to IACUC standards, independently and within a team dynamic.
Design and execute studies ranging from early exploration to IND submission stages, focusing on in vivo/ex vivo sample generation and analysis, PK/PD modeling and therapeutic efficacy.
Performing assays to assess target engagement and biomarker analysis in samples such as blood, bone marrow, and muscle tissue, contributing to our understanding of disease mechanisms.
Develop, optimize and conduct in vitro assays and molecular biology techniques including but not limited to RT-qPCR, ELISA, protein assay and flow cytometry.
Demonstrate independent thought/creativity in science with excellent collaboration and communication across functional disciplines and multitasking skills.
Maintain accurate, timely and complete electronic laboratory notebook entries.

Qualifications

BS or MS with relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an academic or industry setting.
Experience working with rodents, administering doses through various methods including but not limited to PO, IP, IV, SC and IM, and conducting post-study processes including blood draws, necropsies, and ex vivo sample analysis.
Experience with Contract Research Organizations (CROs) is an asset.
Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, RT-qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.
Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.
Proven ability to independently plan and execute experiments, analyze data, and present findings.
A passion for contributing to a team-oriented, diverse, and inclusive work environment.
Excellent multitasking abilities and ability to thrive in a fast-paced, collaborative setting.

Research Associate

3 days ago

Charles River Laboratories Cambridge, United States

**Req ID #**:222988**Location**:Cambridge, MA, US, For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-be ...
Research Associate

1 week ago

Forrester Cambridge, United States

At Forrester, we're trusted to work on trailblazing, mission critical problems that business and technology leaders face today. That's why we're always looking to empower talented individuals to perform at their best every single day. We're proud of our community of smart people ...
Research Associate

1 week ago

Pinetree Therapeutics Cambridge, United States

**About the Company** · Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of ...
Research Associate

1 week ago

TechTrueUP Cambridge, United States

Basic Qualifications · 0+ Years w/ Relevant BS OR equivalent 2+ Years w/ Relevant AS OR equivalent 4+ Years w/ HS Foundational knowledge of technical principles, theories, and concepts to perform routine work in a role · Top 3 Must Have Skill Sets: · MUST be willing to be onsite ...
Research Associate

2 days ago

Eurofins USA PSS Insourcing Solutions Cambridge, United States

**Company Description** · Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, t ...
Research Associate

1 week ago

Generate Biomedicines Somerville, United States

**About Generate:Biomedicines** · Generate:Biomedicines is a new kind of therapeutics company - existing at the intersection of machine learning, biological engineering, and medicine - pioneering Generative Biology to create breakthrough medicines where novel therapeutics are com ...
Research Associate

1 day ago

Point32Health Boston, United States

Who We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
Research Associate

12 hours ago

Harvard University Boston, United States

**Position Description**- **Primary Duties** · - Develop, design, conduct, analyze, and implement research using data science knowledge and prior knowledge of requested statistical packages. Perform statistical programming. · - Exercise independent decision making with regard to ...
Associate Director, Research Finance

12 hours ago

MIT Cambridge, United States

**ASSOCIATE DIRECTOR, RESEARCH FINANCE**, _Office of the Vice President for Research (VPR)-Research Administration Services (RAS)_, to serve as the leader for research finance, providing sponsored research financial oversight, advice, and management on behalf of MIT-wide research ...
Contract Research Associate, in Vivo

3 days ago

Orbital Therapeutics Cambridge, United States

**Company Summary**: · Orbital Therapeutics aims to enhance global health by unleashing the full potential of RNA-based medicines (excluding small interfering RNA) to treat human disease in ways that were not previously possible. The company is building a first-in-kind platform a ...
Scientific assistant/research associate

1 week ago

FusionWorks Cambridge, United States

Waterways are complex water systems. The Federal Institute of Hydrology (BfG), located within the Federal Ministry of Digital and Transport (BMDV), works to make them sustainable and efficient. As the federal scientific institute for research, evaluation, and consultation in the ...
Clinical Research Associate I

1 week ago

Tufts Medical Center Boston, United States

We're saving lives, building careers, and reimagining healthcare. We can't wait to grow alongside you. · **Job Profile** Summary** · This role focuses on performing work related to research and development of new products, innovation, and improvement of products and processes. In ...
Clinical Research Associate Manager-cancer Center

1 week ago

Massachusetts General Hospital(MGH) Boston, United States

**Clinical Research Associate Manager-Cancer Center Protocol Office** · **GENERAL SUMMARY/ OVERVIEW STATEMENT**: · The Cancer Center Protocol Office is seeking a Clinical Research Associate Manager to join our team. The Cancer Center Protocol Office is a centralized clinical rese ...
Research Associate Ii

1 week ago

Ultragenyx Pharmaceutical Woburn, United States

**Why Join Us?** · - Be a hero for our rare disease patients_ · Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learnin ...
Research Associate

1 week ago

Harvard University Cambridge, United States

The Research Associate supports a multi-year research project of the Institutional Antiracism and Accountability (IARA) Project at Harvard Kennedy Schools Ash Center for Democratic Governance and Innovation. The Research Associate is a key member of Research Associate, Research, ...
Research Associate

1 week ago

Harvard University Cambridge, United States

Professor Matthew Lee is seeking a full-time Research Associate for one year or more. This role is a particularly good fit for candidates seeking to pursue a PhD or other research in the management of organizations, whether in a school of public poli Research Associate, Research, ...
Research Associate

1 week ago

Harvard University Cambridge, United States

The Research Associate (RA) will work closely with a diverse team of scholars at The People Lab (TPL) who are passionate about conducting collaborative, applied, data-driven research on key priorities in government. Projects range from: how to recrui Research Associate, Research, ...
Research Associate

1 week ago

Harvard University Cambridge, United States

Basic Qualifications · Bachelor's degree required, along with research experience gained through work experience, internships, or academic work. · Additional Information · This position is a fully benefits-eligible term appointment ending one year from date of hire, with possibil ...
Research Associate

1 week ago

Forrester Cambridge, United States

At Forrester, we're trusted to work on trailblazing, mission critical problems that business and technology leaders face today. That's why we're always looking to empower talented individuals to perform at their best every single day. We're proud of our community of smart people ...
Research Associate

6 days ago

Forrester Research, Inc. Cambridge, United States

At Forrester, we're trusted to work on trailblazing, mission critical problems that business and technology leaders face today. That's why we're always looking to empower talented individuals to perform at their best every single day. We're proud of our community of smart people ...