- Develop and characterize various mouse models
- Perform PD/efficacy studies to support preclinical development of gene therapy candidates
- Perform in vitro, in vivo and ex vivo studies to understand the mechanisms of action of therapeutics
- Prepare, review and deliver scientific findings for internal/external use
- Keep accurate records of research activities and experimental details
- Compliance to animal use policy of welfare and handling
- BS/MS in pharmacology, biology or related disciplines
- Highly skilled in animal colony management, general animal handling, compound dosing (IV, PO, IP and SC), blood collection (tail vein, submandibular/submental), euthanasia and necropsy (tissue collection and processing)
- Experienced in tissue sample processing for molecular biology biomarkers such as DNA, RNA extraction
- Experience in performing protein assays such as ELISA and enzyme activity is a plus
- Experience in AAV gene therapy and genetic mouse models is strongly desired
- Proficiency in basic software (e.g. MS office) and strong data analysis skills
- Excellent interpersonal and collaborative skills, and the ability to work both independently and as part of team
- Proven ability of multi-tasking, strong analytical and problem-solving skills
- Flexibility and aptitude for learning with a passion to drive cutting-edge science
- Application of creativity and problem-solving skills for model and assay development
- Strong ability to work with others in a matrixed team environment
- Candidate must possess critical time-management skills to creatively accomplish challenging tasks in a timely manner
- A positive "can-do" mindset
- The duties of this role are conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
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Director, In Vivo Pharmacology
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Flagship Pioneering, Inc. Somerville, United StatesWhat if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way. · What this position is all about: · Cellarity is seeking an energetic, talented and highly motivated Di ...
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Associate Scientist: In-Vivo Pharmacology
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Proclinical Staffing Cambridge, United StatesAssociate Scientist In-Vivo Pharmacology - Contract - Cambridge, Massachusetts MA · Proclinical is seeking a dedicated and innovative Scientist for the role of Associate Scientist In-Vivo Pharmacology. This is a temporary contract position based in Cambridge, Massachusetts. · Pri ...
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Director, In Vivo Pharmacology
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Cellarity Somerville, United StatesWhat if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way. · What this position is all about: · Cellarity is seeking an energetic, talented and highly motivated Di ...
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Sr. Research Associate, In Vivo Pharmacology
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Scientist I, In Vivo Liver Pharmacology
2 weeks ago
Takeda Pharmaceuticals Boston, United StatesBy clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I sub ...
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Moderna, Inc. Cambridge, United StatesThe Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell models, and the ...
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BioSpace Cambridge, United StatesJob Details · The Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell mo ...
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Scientist I, In Vivo Liver Pharmacology
1 week ago
Takeda Boston, United States Full timeBy clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Noticeand Terms of Use. I further attest that all information I submit ...
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Scientist I, in Vivo Liver Pharmacology
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ARIAD Boston, United States**Job Level**: · Senior**Travel**: · Minimal (if any) · At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, y ...
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Moderna, Inc. Cambridge, United States Full timeThe Role: · We are seeking a talented and experienced Director to lead our in vivo pharmacology research team. The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell models, and the ...
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Adaptimmune Cambridge, United StatesJob Description · Job DescriptionAdaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, ...
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Adaptimmune Therapeutics plc Cambridge, United StatesAdaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologou ...
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Scismic Inc Cambridge, United StatesJob Description · Job DescriptionScismic is supporting the growth of a Cambridge, MA biotech startup that is pioneering mRNA-modulating therapies to cure a broad range of genetic diseases. The company is exploring the use of its novel platforms in neurological disorders, heart di ...
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Bioanalytical Data Reviewer/ Quality Control
2 weeks ago
Artech LLC Lexington, United StatesBioanalytical Data Reviewer/ Quality Control · HYBRID ROLE · Lexington, MA. · Pay Rate Range is $25.34-$32.97 Per hour. MUST HAVES: · Experience being responsible for quality control of all scientific data generated within the Nonclinical Pharmacology group. · Famili ...
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Associate Director, Neuroscience
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Third Rock Ventures Lexington, United StatesAbout Voyager Therapeutics · Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of - and ultimately cure - neurological diseases. Our pipeline includes programs for Alzheimer's disease, amy ...
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PharmaEssentia U.S.A. Bedford, United StatesSenior/Principal Scientist, Translational Sciences · Job summary: · PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and experienced senior or principal scientist to join our Translational Sciences team and contribute to the development of first-in- ...
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PharmaEssentia U.S.A. Bedford, United StatesJob Description · Job DescriptionSenior/Principal Scientist, Translational Sciences · Job summary: · PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and experienced senior or principal scientist to join our Translational Sciences team and contribut ...
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Fractyl Health, Inc Burlington, United StatesReports to: Director, Gene Therapy Research · Position Summary · Working within Fractyl's Gene Therapy Research Team, the Senior/Principal Scientist will be integral to the discovery and development of AAV-based gene therapies for the treatment and cure of diabetes, obesity, an ...
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Bioanalytical Scientist
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Scientist (Bioanalysis)
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TotalMed, Inc. Watertown, United StatesJob Title: Bioanalysis Scientist · Industry/Sector: Biopharmaceutical Manufacturing · Location: Watertown, MA 02472 · Schedule: Monday-Friday 8:00am – 5:00pm; 4-5 days On-Site per week · Pay: $55-$60/hr + Benefits: Med/Den/Vis, 401k · Job Description: · Report directly to the A ...
Sr Research Associate, In Vivo Pharmacology - Lexington, United States - Alexion Pharmaceuticals, Inc.
Description
This is what you will do:
The Senior Research Associate will be a key player in driving genomic medicine pipeline project through target validation, candidate selection and IND-enabling phases using in vitro, in vivo and ex vivo studies.
You will be responsible for:
You will need to have:
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
