- Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets.
- Oversee design and screening of new AAV constructs for discovery
- Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.
- Collaborate with cross-functional teams to advance drug discovery and development projects.
- Analyze and interpret data from in vitro and in vivo pharmacology &safety studies.
- Research latest scientific trends and technological advances in gene therapy.
- Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics.
- Contribute to the preparation of regulatory documents, including IND submissions.
- Mentor and supervise junior scientists in a cross-functional setting.
- Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications.
- Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field.
- 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.
- Drug Discovery for gene therapy or nucleic acid medicines
- Familiar with AAV gene therapy design and development
- CRO management for conducting in vivo research studies
- Designing in vivo gene therapy studies and dosing
- Experience in biodistribution studies and pharmacology related to gene therapy applications.
- Gene therapy assay development
- Designing IND-enabling studies is a plus.
- Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)
- AAV vector design, titering, dosing
- Expertise in in vivo models for biodistribution and pharmacology studies.
- Strong analytical skills and proficiency in statistical data analysis.
- Excellent communication and project management abilities.
- Graphpad, excel etc.
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Principal Scientist, In Silico Discovery
3 weeks ago
Johnson & Johnson San Diego, CA, United StatesJohnson & Johnson is recruiting for a Principal Scientist, In Silico Discovery (ISD). This position can be in La Jolla, CA or Spring House, PA. Remote work options may be considered on a case-by-case basis and if approved by the company. About Johnson & Johnson At Johnson & John ...
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Scientist, Discovery Data Science
4 days ago
Johnson & Johnson San Diego, United StatesJob Description · Johnson & Johnson Innovative Medicine is recruiting for a Scientist, Discovery Data Science to help advance Artificial Intelligence/Machine Learning (AI/ML) for Drug Discovery. This position is located at our R&D site in San Diego, CA (La Jolla area). · At Jo ...
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Senior Scientist, Discovery Biology
1 week ago
Light Horse Therapeutics San Diego, United StatesLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets fo ...
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Senior Scientist, Discovery Data Science
4 days ago
Johnson & Johnson San Diego, United StatesJob Description · Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Discovery Data Science to help advance Artificial Intelligence/Machine Learning (AI/ML) for Drug Discovery. The preferred location for this position is our R&D site in La Jolla - CA. C ...
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Zentalis San Diego, United StatesJob Description · Job DescriptionSalary: $90-125k · JOB SUMMARY: · Responsible for designing and conducting research studies to support our drug discovery programs, including target validation, structure-activity relationship assessment, biomarker discovery, and mechanism of act ...
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Postdoctoral Associate
2 weeks ago
Sanford Burnham Prebys Medical Discovery Institute San Diego, United StatesSanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. _ · **Required**: · - Ph.D. in chemistry or chemical biology · **Knowled ...
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Scientist Ii
3 weeks ago
Wapt San Diego, United StatesOverview: · HD Biosciences Inc. a WuXi AppTec company, is a fast growth, fast paced biology-focused preclinical drug discovery contract research organization (CRO). We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identi ...
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Scientist, Bioinformatics
2 weeks ago
iBio, Inc. San Diego, United States: · **About iBio** · **The Opportunity** · iBio is excited to announce a new opportunity for a Bioinformatics Scientist to join our world-class Platform team in Sorrento Valley, San Diego. As a Bioinformatics Scientist, you will be responsible for executing iBio's core machine le ...
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Principal Scientist
1 week ago
Novartis San Diego, United States**About the Role**: · Hybrid · About the role: · This vital Computer-Aided Drug Discovery (CADD) role, located at our San Diego, CA site, will join our talented and innovative drug discovery team. At Novartis, we value your ideas, personal growth and career aspirations. You will ...
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Associate Scientist, Bioassays
3 weeks ago
Arrowhead Pharmaceuticals San Diego, United StatesArrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead thera ...
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Director of Quality
2 weeks ago
BIOSERO San Diego, United States**Do you want to support scientific research that fuels innovation in healthcare, therapeutics, agriculture, and more?** · - Do you want to enable the world's top scientists to deliver impactful solutions faster? · - Do you believe that the best team wins? · - Do you thrive on pr ...
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Associate Director, Medicinal Chemistry
2 weeks ago
Neomorph, Inc. San Diego, United States**Position summary**: · **Role and responsibilities**: · - Lead medicinal chemistry efforts simultaneously on multiple projects from the earliest stages through to clinical development. · - Ensure the success of chemistry aspects of the drug discovery teams through individual con ...
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Scientist
3 weeks ago
Enqubio San Diego, United States**Overview** · EnquBio, a dynamic technology-driven discovery and service company, is actively searching for a highly capable and self-motivated Scientist to join our rapidly growing team in San Diego. As a key member of the In Vivo Pharmacology team, you will play a critical rol ...
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Service Program Analyst Ii
2 weeks ago
Illumina San Diego, United StatesWhat if the work you did every day could impact the lives of people you know? Or all of humanity? · At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are t ...
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Scientist-i/ii, Translational Medicine
3 weeks ago
Regulus Therapeutics Inc San Diego, United StatesAt Regulus, we have fostered a culture that values scientific rigor, creative problem solving, collaboration across departments and disciplines, and persistence in the face of obstacles. · Above all else, we are inspired by the many individuals worldwide affected by genetic kidne ...
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Belharra Therapeutics, Inc. San Diego, United States**WHO WE ARE** · **WHAT WE ARE LOOKING FOR** · **WHAT YOU'LL BE RESPONSIBLE FOR** · ***Compound Management Team members are responsible for organizing and delivering correct requested compounds on time: · - Conduct all activities in a safe and efficient manner. · - Fulfill compou ...
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Vp Philanthrophy
1 week ago
Sanford Burnham Prebys Medical Discovery Institute San Diego, United StatesSanford Burnham Prebys Medical Discovery Institute is dedicated to recruiting the best scientists across various disciplines, including cancer biology, neurobiology, immunobiology, and biology of development, regeneration, and aging. Leveraging the Prebys Center, the Institute's ...
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Scientist - in Vivo Pharmacology - Preclinical
2 weeks ago
Capricor Inc San Diego, United States**Position**:Scientist - In vivo Pharmacology - Preclinical · **Responsibilities**: · - Work with the Associate Director, providing in vivo pharmacology expertise. · - Plan, execute and manage in vivo studies, including protocol development, dosing and tissue collection, study mo ...
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Technical Support Scientist
1 week ago
ScaleBio San Diego, United StatesAt ScaleBio we have a shared mission built upon a demonstrated technology with long term investment commitments and R&D facilities in San Diego and Bay Area, CA. We are seeking team members that have a passion for developing technologies that benefit the broader researcher commun ...
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Associate Director, Marketing
3 weeks ago
GeneDx San Diego, United States**Associate Director, Marketing** · GeneDx is a patient-centric health information company that delivers personalized and actionable health insights that inform diagnosis, guide treatment and improve drug discovery. The company is transforming healthcare through its industry-lead ...
Principal/Senior Scientist, Discovery - San Diego, United States - Lexeo Therapeutics
Description
About LexeoLexeo Therapeutics is a New York City-based, clinical-stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer's disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer's disease programs.
Primary Responsibilities
Depending on qualifications and overall experience, base salary is likely to $150,000 - $190,000 per year.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
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