Scientist-i/ii, Translational Medicine - San Diego, United States - Regulus Therapeutics Inc

Description

At Regulus, we have fostered a culture that values scientific rigor, creative problem solving, collaboration across departments and disciplines, and persistence in the face of obstacles.

Above all else, we are inspired by the many individuals worldwide affected by genetic kidney diseases and other genetically-based, orphan diseases.

Located in San Diego, California, we are a dedicated team of scientists, researchers, and biotech professionals committed to learning and growth, and to the patients we serve.

Position description and scope:


Job responsibilities:

• Interpret and monitor both clinical and preclinical biomarker data and communicate regularly with team members to troubleshoot experiments and coordinate tasks as needed.
• Independently design, develop, validate and perform various cellfree and cellbased assays to evaluate the activity of potential microRNA therapeutics and to elucidate the mechanisM/Function of specific molecular targets in vitro.
• Perform protein and RNA extraction from exosome preparations, cells, tissues and mouse and human fluid samples. Prepare and submit samples for omic analysis including nextgeneration sequencing.
• Analyze RNAseq (bulk, single nuclei, spatial transcriptomic) and perform metaanalysis using new and existing omics data.
• Plan, coordinate and manage CRO and academic collaborations studies.
• Maintain a high level of familiarity and understanding of the current literature on microRNA biology, novel oligotherapeutic technologies, and how they relate to specific therapeutic areas of interest.

Minimum Qualifications:

• PhD in Cell and/or Molecular Biology or related discipline and 2 years of postdoctoral drug discovery experience in a biotech or pharmaceutical industry.
• Strong experience in various cell and molecular biology techniques including, cell culture (primary and stable cell lines), transfection, stable cell line generation, MSD, ELISA, RNA purification, RTqPCR, western blots and other standard cellbased or biochemical assays.
• Experience with both in vitro and in vivo models for kidney biology, biomarker development and exosomes knowledge.
• Experience with liquids handling and automation.
• Effective interpersonal skills, including both written and oral communication skills.
• Ability to multitask, prioritize, and function in a fastpaced entrepreneurial environment.
• Demonstrated ability to generate reproducible results, and to teach others.

Preferred Qualifications:

• PhD in Cell and/or Molecular Biology or related discipline and 25 years of postdoctoral drug discovery experience in a biotech or pharmaceutical industry.
• Basic understanding of oligonucleotides drug discovery.
• Experience in working with and managing CROs and academic collaborations.
• Experience with a range of platforms (Fluidigm, Hamilton and JESS).
• Working knowledge of microRNA biology, diseasebased cell modeling, and in vivo preclinical disease models.
• Understanding the principles of pharmacokinetics and pharmacodynamics.
• Experience with metabolomics and proteomics data analysis.
• Proficiency in R is a plus.

Benefits:

• The expected hiring range for this multilevel position is $97,000 to $133,000 per year, commensurate with educational level and experience. Consideration will be given to experience that exceeds the listed requirements.
• Access to 401k plan with generous employer match.
• Full suite of health plans including medical plan options, dental, vision, life insurance, disability, EAP and more.
• Access to Flexible Spending Accounts.
• Competitive vacation, paid holiday and sick leave policies.

Benefits.**:

Regulus provides a competitive benefits package that includes a choice of health, vision, and dental insurance, life insurance, flexible spending accounts, 401K plan, vacation and stock options.

We believe that you, as an employee, matter above everything else. We back that statement up continuously with a unique approach to providing you with great benefits and valuable resources.

Our benefits packages and resources are designed to support you in creating the life and work style that brings your best to your community, your family and Regulus' mission of addressing significant unmet medical needs.

Most of our benefits cover employees who work at least 30 hours a week and their eligible dependents


Eligible dependents include:

• A spouse or domestic partner
• Children (biological, step, foster, adopted or legal charge) up to age 2
• The majority of our benefits become effective immediately on the date of hire without any preexisting condition exclusion (temporary employees, contractors, interns and coops are not eligible for benefits).

In addition to an array of health and financial benefits and learning opportunities, we offer competitive compensation and bonus programs that reward you for your contributions toward achieving the company's mission and strategic goals.

We also provide you with a wide