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    Postdoctoral Fellow-MSH-13400-323 - New York, United States - Mount Sinai Hospital

    Mount Sinai Hospital
    Mount Sinai Hospital New York, United States

    1 week ago

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    Description
    Job Description

    The Panagiotakos Lab, in the Departments of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York, is seeking postdoctoral fellows with expertise in calcium imaging, electrophysiology, developmental neuroscience, stem cell biology, and/or genomics/sequencing approaches to study cellular and molecular mechanisms that underlie the acquisition of cell fate during mammalian brain development. Dr. Panagiotakos' team combines multiple complementary approaches, including genetic mouse models, calcium imaging, fluorescence microscopy, pharmacology, cortical slice cultures, and various omics and biochemical analyses, to interrogate roles for ion channels, electrical activity and calcium signaling during normal development and in the context of neuropsychiatric disorders of developmental origin. The qualified candidate will use cutting-edge cellular/molecular biology, imaging and sequencing approaches in these studies, including long-isoform sequencing and live imaging, to investigate the impact of disease-relevant ion channels and calcium signaling on cellular events during brain development, including proliferation, migration and differentiation.

    Responsibilities

    Web link to Department: Detail of Research Project:

    The goals of these studies are to interrogate mechanisms by which intracellular calcium signals link

    extracellular cues with intrinsic differentiation programs and to elucidate how alternative splicing refines these signals, and to investigate roles for calcium signaling pathways on cortical development.

    Technical Duties: (include any protocols)
    • lead independent projects focused on defining cell type specific splice isoforms and calcium signaling mechanisms
    • technical toolkit will include: long-isoform sequencing, single cell RNA sequencing, genetic mouse models, calcium imaging, bioinformatics analysis, in vivo mouse surgeries, various molecular biology approaches, immunofluorescence staining and microscope
    • work collaboratively and contribute to mentoring junior lab members
    • cultivate scientific communication skills by contributing to the writing of grant applications and manuscripts and participating in work in progress meetings and other seminar series"
    Qualifications

    Basic qualifications:
    • PhD or MD/PhD in Developmental and Stem Cell Biology, Neuroscience, or Cellular/Molecular Biology;
    • Demonstrated expertise in cellular/molecular neuroscience, developmental neuroscience, or stem cell biology;
    • Record of publications in peer-reviewed journals;
    • Excellent oral and written communication skills;
    • Ability to work in an international and interdisciplinary team;
    Experience Required:

    The postdoctoral candidate must have a Ph.D. degree in the biological sciences (or proof of completion of all Ph.D. requirements prior to starting) with training/experience in developmental neuroscience, neuroscience, and/or stem cell biology and corresponding cellular/molecular biology bench skills. Preference will be given to candidates with a strong record in techniques for studying calcium signaling, including calcium imaging and electrophysiology. Experience in sequencing approaches with relevant bioinformatics skills is a major plus.

    Non-Bargaining Unit, 859 - Psychiatry - ISM, Icahn School of Medicine

    About Us

    Strength Through Diversity

    The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:
    • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
    • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
    • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.
    We work hard to acquire and retain the best people and to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to professional advance. We share the belief that all employees, regardless of job title or expertise contribute to the patient experience and quality of patient care.

    Explore more about this opportunity and how you can help us write a new chapter in our history

    "About the Mount Sinai Health System:

    Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

    The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism."

    EOE Minorities/Women/Disabled/Veterans
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