- Assist with internal troubleshooting and optimization efforts of the downstream purification process for multiple protein antigens across the Vaxcyte pipeline; the purification process must be robust, scalable, and cost-effective.
- Generate material for analytical method development.
- Participate in cross-functional project teams and provide regular progress updates.
- Contribute to the generation of data packages to facilitate technology transfer activities for the processes developed at Vaxcyte to external CMOs.
Requirements: - Bachelor's with 7+ years' experience or Master's Degree with 5+ years' experience.
- Strong protein purification knowledge and experience, including familiarity with AKTA lab-scale and preparative chromatography systems and UNICORN software.
- Proficiency running gel- and column-based analytical methods a plus; such methods may include SDS-PAGE, Western blotting, IEF, SEC, HIC, IEX, and binding affinity or activity assays (such as MSD or ELISA).
- Experience and understanding of depth, nominal, and tangential flow filtration.
- Strong interpersonal skills, with excellent written and verbal communication skills.
Reports to: Senior Scientist, Downstream Development
Location: San Carlos, CA
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $125,000 – $130,000 -
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Scientist I, Downstream Development - San Carlos, United States - Vaxcyte, Inc.
Description
Join our Mission to Protect HumankindVaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.
WHAT we do is every bit as important as HOW we do it Our work together is guided by four enduring core values:
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Summary:
Vaxcyte is looking for an energetic and talented individual to join Vaxcyte's Vaccine Product Development organization as a Scientist I of downstream development and manufacturing within the Protein Development and Manufacturing group. The successful candidate will have the following skills and qualities:
· An exceptional team member that contributes to the team and fosters a highly collaborative work environment.
· A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals.
· A curious scientist/engineer who enjoys lab work, the process of discovery, and applied innovation.
· The ability to analyze and clearly present data, draw conclusions, and communicate salient points concisely.
· A strong sense of ownership and accountability; commitment to Vaxcyte's mission.
Essential Functions:
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