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    Postdoctoral Research Scientist-Clinical Pharmacology and Toxicology Laboratory - New York, United States - Columbia University

    Columbia University
    Columbia University New York, United States

    1 week ago

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    Description

    The Clinical Pharmacology and Toxicology Laboratory (CPTL) in the Department of Pathology & Cell Biology at Columbia University Irving Medical Center is a CLIA-certified laboratory that develops High Performance Liquid Chromatography and quantitative mass spectrometry-based assays to measure therapeutic drugs in blood and urine samples in support of clinical studies and patient care. The laboratory is led by Drs Cremers and Lyashchenko. The laboratory also conducts clinical TDM, and translational and clinical pharmacokinetic and pharmacodynamic studies.

    The CPTL has a position open for a postdoctoral student to develop assays for various antibiotics and conduct translational and clinical studies with Intensive Care Unit (ICU) patients on Continuous Renal Replacement Therapy (CRRT), that involve PK/PD modeling and simulation. This NIH-funded project is a collaboration with the Divisions of Experimental Therapeutics (Drs Stojanovic and Lin) and Nephrology (Dr Mohan) and is aimed at developing aptamer-based assays for in-line monitoring of antibiotics coupled to automated dose adjustments during CRRT.

    At CUIMC, we stand together because diverse experiences, perspective, and values enrich every dimension of our work. Join our team and see how your unique skills and experiences can create a real impact by changing lives.

    Job Function :

  • Develop and validate HPLC and LCMSMS assays to quantify antibiotics in plasma and dialysate.
  • Validate newly developed aptamer-based assays for antibiotics.
  • Develop and conduct translational and clinical PK and PD studies with antibiotics in ICU patients on CRRT.
  • Develop PK and PD models to optimize dosing of antibiotics in ICU patients on CRRT.

    • Lab Mission/Purpose:

    Minimum Education Requirements:

  • MD, PharmD and/or PhD in clinical pharmacology or similar background

    • Minimum Skills Required:

  • Experience with PK/PD Modeling and Simulation
  • Experience with HPLC or LCMSMS
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