Vadanasundari Vedarethinam

A highly professional scientist with proven experience in biomedical applications over 6 years for

disease diagnostic devices and various biomedical applications. Enormous experiences in analysis of

biomarker detection . Excellent interpersonal skills to

communication and collaborate effectively with coworkers. Strong interpersonal skills and recognized for

professionalism, commitment, and dedication to excellence.

EXPERIENCE

Weill Cornell Medicine,

Postdoctoral research associate

• Development and preclinical validation of small

molecule cancer therapeutics

• Working analytical skills in identifying fibroblast

activation protein (FAP) in animal models from bladder

cancer mouse

• Molecular therapeutics screening (in vitro and in vivo

model)

• Preclinical tumor imaging contrast for clinical applications

• Analytical experiments in peptide synthesis, purification,

and identification by HPLC and mass spectrometry

• Formulation of cyanine 5.5 and FAP inhibitor

conjugated with peptides for targeted drug delivery and

imaging

• Mammalian cell culture and FAP protein identification

by cell sorting using flowcytometry

• Cell lysis and protein extraction and identification by

mass spectrometry

• Tumor implantation to mouse model for FAP targetted

drug delivery and molecular imaging by cyanine 5.5

conjugated peptide

• Biochemical analysis of drug delivery system in a

mouse model

• Design, plan and execute experiments

• Manage projects, record and data analysis

• Write research papers, proposals, reviews, and reports

• Organize product and materials testing.

Nanomaterials

Characterization

• Biophysical methods (DLS/Zeta/XRD/XPS/TEM/SEM).

• Chromatographic methods (TLC, HPLC, UV-Vis

Spectroscopy, Mass Spectrometry)

• Analytical method validation

Microbiology

• Bacterial culture

• Media formulation and optimization

• protein extraction and purification

• Metabolites extraction and molecular determination

• Bacterial growth inhibition assay

• Microscopic analysis.

EDUCATION

Shanghai Jiao Tong University,

Postdoc fellow

• Nano-Formulation project (Metal NPs/ polymer

hybrids/ micelles/ Peptide-PEG-PLGA NPs)

• Biomolecule (proteins, amino acids, carbohydrates,

small metabolites, lipids, organic compounds)

identification by mass spectrometry

• Nanoparticle-mediated cancer biomarker detection

from cancer cell lines and human biofluid samples

• Formulation of drug/ ligand/fluorescent dye

conjugated nanoparticles for targeted receptor protein

detection and separation

• Nanoparticles physical & chemical analysis and

characterization

• Product purification and analysis of drug-conjugated

nanoparticles

• Metabolites and protein extraction from biofluids and

molecular analysis by mass spectrometry and

determination by human metabolome database

(HMDB)

• Bacterial cultivation with optimized media formulation

for protein extraction and identification by mass

spectrometry

• Small molecules (< 1000 m/z) extraction from bacteria

and identification by HMDB

• Responsible for scientific communications (papers,

conference abstracts, seminars)

• Laboratory maintenance

• Obtaining research fundings

• Training and mentorship of undergraduate students.

Ph.D Researcher

• Preclinical validation for the delivery of synthetic

molecule for HCC

• Histopathological analysis of HCC tumor tissue

• Tissue homogenization, cell lysis, and protein extraction

• Proteomic evaluation of elevated HCC biomarkers

Education:

PRIST University, TN, India Ph.D. Biotechnology Engineering 

PRIST University, TN, India M. Tech. Biotechnology Engineering 

Bharathidasan University, TN, India M. Sc. Biotechnology 

Bharathidasan University, TN, India B.Sc. Nutrition & Dietetics