- Collaborate with our Metabolism and Immunology teams to design, build, and employ in vivo models to support therapeutic development
- Engineer humanized liver models for reprogramming therapeutics discovery screens
- Evaluate reprogramming therapeutic candidates using in vivo functional assays to select therapeutic candidates
- Develop methods for in vivo delivery of nucleic acid payloads in collaboration with our Epigenetic Editing team
- Analyze and interpret experimental data to drive pre-clinical decision making
- B.S. and 3+ years of work experience or Ph.D. in cell biology, molecular biology, physiology, or a related field or equivalent work experience.
- Experience with in vivo surgical and dosing procedures in rodent models (mouse or rat)
- Experience managing an in vivo model breeding program
- Experience with cell and tissue isolation from in vivo models
- Experience with histology or immunohistochemistry preparation
- History of contributing to a drug development program at the pre-clinical or clinical development stage
- Experience working with liver disease models and associated procedures
- Experience working with immunocompromised humanized mouse models
- Experience with in vivo nucleic acid delivery (hydrodynamic, viral vectors, lipid nanoparticles
-
Scientist
1 day ago
Validation Associates South San Francisco, United States**Description**: · Onsite - 8-5pm · PHD required - No working experience required but the more experience the better. · **Summary** · This Scientist will focus on developing and executing primary cell and whole blood assays to support Amgen's small molecule drug discovery pipelin ...
-
In Vivo Research Associate
2 weeks ago
Compass Consulting South San Francisco, United StatesOur client is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. · Duties: · This person will be a part of the preclinical drug discovery and development team. · Participate in ...
-
Research Associate I
1 week ago
ApTask South San Francisco, United StatesJOB DESCRIPTION: · We are seeking a highly motivated individual to join the Physiological Chemistry Department at Genentech in a contract position. A successful candidate will participate in the identification of Client components in innate immune responses and cell death pathway ...
-
Associate Director
1 week ago
BioPhase South San Francisco, United StatesAssociate Director · $170-200K + bonus & equity · Responsibilities: · As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities includ ...
-
Staff Research Associate Iii
5 days ago
University of California Berkeley Berkeley, United StatesStaff Research Associate III (9611C), Nutritional Sciences & Toxicology About Berkeley · At the University of California, Berkeley, we are committed to creating a community that fosters equity of experience and opportunity, and ensures that students, faculty, and staff of all bac ...
-
Preclinical Neuroscientist
1 week ago
Neurona Therapeutics South San Francisco, United StatesPreclinical Neuroscientist · Neurona Therapeutics is a clinical-stage biotechnology company based in South San Francisco focused on the development of cell-based therapies for neurological diseases. Our ideal candidate is a self-motivated individual who has a passion for the clin ...
-
Gordian Apprenticeship
1 week ago
Gordian Biotechnology South San Francisco, United StatesAre you ready to take on pivotal work that will aid Gordian Biotechnology in pinpointing the most promising therapeutic targets for the development of novel drugs? Join our inaugural Apprenticeship Program and help us on our mission to cure age-related disease. We want people to ...
-
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native Complex Platform recapitulates GPCR ...
-
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native ComplexTM Platform recapitulates GP ...
-
Research Associate III
1 week ago
Aequor Technologies LLC South San Francisco, United StatesThis position is in the Investigative Toxicology Group within the department of Safety Assessment in Genentech s Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed n ...
-
Research Associate III
1 week ago
HonorVet Technologies South San Francisco, United StatesDescription: · This position is in the Investigative Toxicology Group within the department of Safety Assessment in Genentech's Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that ...
-
Senior Researcher
3 days ago
BEPC Inc. - Business Excellence Professional Consulting South San Francisco, United StatesBEPC has an open position for a Research Associate III in South San Francisco, CA · Contract W2 Period: 12month contract with possibilities for extensions. · Pay & Benefits: $43-$50/hr. + Medical, Dental, Vision and Life Insurance · The mission of the Investigative Toxicology gro ...
-
SGA Inc. South San Francisco, United StatesSoftware Guidance & Assistance, Inc., (SGA), is searching for a Scientific Researcher, Investigative Toxicology for a CONTRACT assignment with one of our premier Pharmaceutical Services clients in South San Francisco, CA. · Responsibilities: Firm has an open Scientific ...
-
Scientist, Biology
6 days ago
Brightseed South San Francisco, United StatesABOUT THE ROLE · At Brightseed, you will be a part of building out an innovative biological investigation capability to uncover the health benefits of natural molecules isolated from major domains of life including plants, fungi, and microbes. As an expert biologist with a passio ...
-
Head of Translational Genomics
6 days ago
Gordian Biotechnology South San Francisco, United StatesAre you ready to spearhead Gordian's efforts to improve clinical success rates by matching our targets and vast genomic datasets from different species to patient endotypes, working with disease experts to set a vision for collecting and analyzing samples to reduce uncertainty ab ...
-
Postdoctoral Fellow
1 week ago
Cytokinetics, Incorporated South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
-
scientist, biology
1 week ago
Brightseed South San Francisco, CA, United StatesABOUT BRIGHTSEED · Brightseed is a pioneer in biosciences and artificial intelligence (A.I.) that illuminates nature to restore human health. Brightseed's proprietary A.I., Forager, accelerates bioactive discovery, biological validation and ingredient formulation from years to mo ...
-
Scientist/Sr Scientist, Research Physiology
1 week ago
California Life Company San Francisco, United StatesWho we are: · Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to de ...
-
Scientist/Sr Scientist, Research Physiology
2 weeks ago
California Life Company San Francisco, CA, United StatesWho we are: · Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to d ...
-
Research Health Science Director
2 weeks ago
Longevitylist San Francisco, CA, United StatesTo restore cell health and resilience through cellular rejuvenation programming to reverse disease, injury, and the disabilities that can occur throughout life. · We believe that diverse perspectives are foundational to scientific innovation and inquiry. · We are building a com ...
Scientist, In Vivo Physiology - South San Francisco, United States - NewLimit
Description
Company infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with in vivo physiology experience to contribute to our Metabolism and Immunology programs. Our therapeutic programs are developing reprogramming medicines to restore youthful function in old cells, treating otherwise intractable conditions. In this role, you will design and implement state-of-the-art in vivo models to facilitate the development of these reprogramming medicines, contribute to Discovery and pre-clinical decision making, and serve as a subject matter expert.
As a Scientist on our team, you will:
