- Designing and executing in vitro and ex vivo studies to advance therapeutic programs.
- Generating, analyzing, and interpreting complex data to establish functional PK/PD and efficacy relationships, elucidating the therapeutic mechanism of action for lead drugs.
- Serving as the Disease Biology lead on multiple project teams, conducting and troubleshooting experiments, and collaborating cross-functionally to identify and mitigate risks for effective program advancement.
- Contributing to the development of complex in vitro and ex vivo research and development capabilities.
- Authoring and reviewing protocols, study reports, and regulatory documents to facilitate IND and other regulatory filings.
- Following all company policies/practices and maintaining accurate records and notebooks.
- PhD in Endocrinology, Physiology, Diabetes/Obesity, Immunology/Inflammation, or a related biological science (MS with relevant years of experience).
- At least 8 years of direct hands-on experience in therapeutic development leveraging indication-specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 12 years).
- Hands-on experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g., IF/IHC/ISH), and/or flow cytometry.
- Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays.
- Proven ability to collaborate in writing protocols, reports, and regulatory documents.
- Outstanding communication skills with a demonstrated ability to make effective presentations.
- Experience with therapeutics programs that have yielded drugs entering clinical development in areas such as endocrinology, diabetes/obesity, immunology/inflammation, or metabolic disease.
- Familiarity with microscopy, confocal imaging, or similar techniques.
- Experience working as a subject matter expert with complex cell-based 2D/3D culture systems or ex vivo tissue models or patient-derived samples.
- Ability to generate, analyze, and interpret multi-omic data sets.
- Proficiency in establishing workflows, using Jupyter notebook or other platforms for bioinformatics analysis, and interpreting/visualizing complex data sets.
- Previous experience leading a program in therapeutic discovery/development.
- Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results.
- Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams.
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Associate Director - South San Francisco, United States - BioPhase
Description
Associate Director
$170-200K + bonus & equity
Responsibilities:
As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include:
Required Qualifications:
