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THE SIR2 FAMILY OF PROTEIN DEACETYLASES
https://web.mit.edu/biology/guarente/references/21.pdf">https://web.mit.edu/biology/guarente/references/21.pdf
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THE SIR2 FAMILY OF PROTEIN DFACETYIASES
Gil Blander and Leonard Guarente
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Key Words $22. deacetylase. NAD", calor tosirson, gg.
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CONTENTS
THE DISCOVERY AND (DENTIICATION OF $02 aw
CATALYTIC MECHANISM hn
STRUCTURE OF THE SIR2 FAMILY PROTEINS. «0
INHIBITORS AND ACTIVATORS a
CHILLAK LOCALIZATION. PROTHN INTERACTIONS AND PROTEIN
SUBSTRATES o
Yes Sa ©
Hacer Se? os
Ercucghils Se oe
Apna a S07 oc
SUK AND AGG so
CALORIC RESTRICTION 1
CONCLUSION, a
THE DISCOVERY AND IDENTI]
CATION OF SIR2
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SIR pone, winch we responsible for subcrcing 31 repeated DNA sequences 18
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