- Plan and execute cellular and biochemical assays (enzyme activity assays, growth and viability assays, HTRF, etc.).
- Perform and contribute to multi-plexed HTS screening assays.
- Lead CRISPR-Cas9 perturbations and downstream analysis.
- Evaluate protein-protein interactions through NanoBiT, IP-MS, ALPHAscreen, etc.
- Large scale proteomic sample preparation
- Perform cell line engineering and QC.
- Reporter and phenotypic assay development and implementation.
- Maintain impeccable experimental records in an ELN.
- Independently identify and solve technical experimental problems.
- Collaborate closely with all members of the Magnet team.
- Other duties, as assigned.
- Bachelors or Masters degree in biology or related discipline and 3-5+ years experience in a biotech or pharmaceutical setting
- Experience in human cell culture techniques for diverse cell types, including cell line engineering and QC
- Expertise in cellular and molecular biology, including reporter systems and phenotypic assays
- Ability to perform meticulous experimental planning, execution, and analysis
- Strong analytical mindset and knowledge of relevant statistical methods
- Intellectual curiosity and a positive, collegial attitude
- Expertise with lentiviral packaging and transduction to generate engineered cell systems
- Ability to work at scale in 384-well format; handle/expand cells for HTS and follow-up experiments
- Experience in oncology and/or immunology, with a basic understanding of the human genetics in those areas and target dependency
- Hands-on experience with small-molecule binding/inhibition assays
- Experience with B and T cell models
- Experience with molecular glue therapies or bifunctional molecules
- Proficiency in confocal and fluorescent microscopy
- Working knowledge of DNA-encoded library screening
- Setup and execution of proteomic workflows and sample prep
- Experience with HTRF, AlphaLISA, and bioluminescence assays
- Propagation of primary cells
- Background in protein biochemistry
- Please apply at
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Principal Research Associate/Associate Scientist, Cell Biology - Boston, United States - Magnet Biomedicine
2 weeks ago
Description
Principal Research Associate/Associate Scientist, Cell BiologyAbout Magnet Biomedicine
Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery.
Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a diverse array of target classes.
Our mission is to generate novel protein-protein interactions to modulate target functions, thereby revolutionizing the field of targeted therapeutics and drug discovery.
We are seeking a highly motivated and experienced, full-time BS/MS level cell and molecular biologist to join our dynamic team, based out of 321 Harrison Ave, Boston, MA.
We offer a competitive compensation package as well as comprehensive benefits.Job description
Principal Research Associate/Associate Scientist, Cell Biology
As a Principal Research Associate/Associate Scientist on the biology team at Magnet Biomedicine, you will play a pivotal role in designing, executing, and interpreting experiments to develop assays for modulating protein-protein interactions using small molecules.
Key Responsibilities
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