Principal Scientist, Exploratory Biopharmaceutics - New Brunswick, United States - Bristol Myers Squibb

Description

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .

Drug Product Development (DPD)

Our Drug Product Development team is committed to CMC design, development, and commercialization of innovative drug products to improve patient lives. We leverage the best people, collaboration, and cutting-edge innovation to achieve this commitment. BMS's internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules, protein biotherapeutics, protein degraders, and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products. Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

Position Summary

In Exploratory Biopharmaceutics (EB), you will have the ability to impact the lives of patients by working with multi-disciplinary research teams to help in developing novel, efficacious and safe therapeutic molecules. BMS is looking for a Principal Scientist with a desire to contribute in the fast-paced early development matrix environment by assessing drug product bio-performance risks, devising mitigation strategies, and providing technical inputs to drug product development teams.

Job Responsibilities

• Candidate will be part of a drug product development team, responsible to evaluate Biopharm risk with drug product and layout a mitigation strategy.
• Successful candidate must demonstrate expertise and proficiency in at least two of the following experimentation types: biorelevant in vitro dissolution, in silico absorption modeling (e.g., GastroPlus) and preclinical in vivo studies.
• The incumbent candidate must have a proven track record of planning and executing rodent and non-rodent PK studies with different route of administration. Candidate should be an expert in pharmacokinetic analysis leveraging Phoenix or equivalent software packages.
• Candidate should have a sound technical understanding and hands-on experience within silico absorption modeling and simulation.
• The candidate will be responsible to provide Biopharmaceutics technical leadership and subject matter expertise (SME) in cross functional drug product development team.
• Candidate should display technical awareness in various aspects of drug discovery, discovery-development interface, and early clinical development, including advising technical project teams on biopharma risks as they develop dosage forms for clinical testing.

Job Requirement

• This position requires a Ph.D. in Pharmaceutical sciences or related scientific disciplines (biotechnology, biomedical, pharmacology) with 4-6 years relevant experience in Biopharmaceutical risk assessment.
• Must have in-depth understanding and experience of animal study design, dosing, and sample collection in compliance with animal safety and welfare.
• Demonstrated biopharmaceutics expertise in in vitro, in silico and preclinical in vivo studies.
• Expertise is conducting compartmental and non-compartmental PK analysis, providing data interpretation and summary presentations/reports is essential.
• Candidate should have expertise in applying creative solutions to in vivo study design and interpretation of results to inform preclinical risk assessment of assets in the pipeline.
• A strong experience record in biopharmaceutical risk assessment of innovative drug products including publications and presentations is preferred.
• Exhibit strong collaboration and interpersonal skills, with the ability to interface with and influence a broad range of internal and external stakeholders at all levels of the organization.
• Candidate must be familiar with state-of-the-science for novel tools and models reported academia and industry.
• Demonstrated passion for fostering innovation and working with an entrepreneurial mindset in a matrix environment
• As an individual contributor, the candidate must possess exceptional organizational, communication, & critical thinking skills, and have the ability to influence others in matrix teams.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through scienceTM , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.