- Develop/code and validate mathematical PK/PD/Biomarker/Efficacy models to elucidate the quantitative PK/PD relationships in pre-clinical species.
- Perform advanced troubleshooting for the related mathematical models independently.
- Work with Clinical Pharmacology to assess the clinical potential for drug-to-drug interactions using physiology-based PK (PBPK) modeling tools (e.g., SimCYP).
- Apply expertise in drug metabolism and pharmacokinetics (DMPK) principles and translational QP and PKPD methodologies as studies move from preclinical to clinical phases.
- Draft PBPK reports in support of regulatory submissions.
- Demonstrate an astute understanding of the PKPD and QSP field and the relevant literature.
- Utilize pre-clinical data for human efficacious dose prediction.
- Prepare peer-directed presentations for the internal scientific communit
- Ph.D. (or equivalent degree) in Chemical Engineering, Pharmaceutical Sciences, or related discipline with 4+ years of related experience
- PKPD modeling software, such as MATLAB, Phoenix, ADAPT and NONMEM
- PBPK modeling software, such as Gastroplus, SimCYP
- Basic programming language: R, Python, etc.
- Prior DMPK team lead experience
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m/s tele rn
2 weeks ago
Integrated Resources, Inc Salem, MA , USA, United StatesShift : 19:00 - 07:30 · 1. *** M/S Tele Float Pool RN - Nights & EOW - 36hrs. - MUST BE ABLE TO READ TELE STRIPS & PERFORM CARDIAC DRIPS. *** 2. Unit Description: Float throughout the hospital to all Med/Surg areas (Dav 5, Dav 7, Dav 8, Dav 9, ED, PH6/7, Pingree 4, & Overflow). ...
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M/S Tele RN
3 weeks ago
Optimum Staffing, Inc. Salem, United StatesJOB ID: MRN009785 · Position:M/S TEL RN Days/Eves/Nights Rotate & EOW 36hrs · Shift Schedule:Days/Eves/Nights Rotate · Location: Salem, MA, 01970 · Job Type: Traveler · Start date:12/19/ /16/2024 · Pay Scale: $60-$65/hr · Job description The Registered Nurse is responsible f ...
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M/S Tele RN Nights
1 week ago
CareTeam Solutions Salem, MA, United StatesDetails: Must Have 2+ Years of recent Medical/Surgical/Telemetry experience.Specialty: Medical/Surgical/Telemetry · Discipline: Registered Nurse · Start Date: · Duration: 13 Weeks · Shift: 12 Hours Overnight shift. · Hours Per Week: "NA" · Employment Type: Contract · Gross ...
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Content Marketing Associate
3 weeks ago
G2 Capital Advisors Boston, United States**About G2 Capital Advisors** · **About the Role**: · We are not your typical investment bank. The G2 team is made up of former C-level owners and operators who intimately understand the complexities of running a business We pride ourselves on meeting our clients where they are, ...
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Maintenace Manager
3 weeks ago
Aramark Boston, United StatesMaintenance Manager Sr. ? Boston, MA - CitizenM · - Agreement? · - 5 year renewal · - Size of the account · - Hotel ? (300) rooms ? (1) site · - How many FTE?s · - Will be overseeing (2) FTE?s · - Temp labor · - Only Aramark POC on-site · - Nonunionized · - Shift schedule · - M-F ...
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Lead Osw Onss Engineering
1 week ago
Avangrid Boston, United StatesJob Title: Lead OSW ONSS Engineering · Location: Boston, MA · Work Model: Office · **Salary**: The base salary range for this position is dependent upon experience and location, ranging from $130k to $160k · Company Description: · Avangrid Renewables, a subsidiary of Avangrid, In ...
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Registered Client Service Associate
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Morgan Stanley Boston, United StatesRegistered Client Service Associate** · Job Number: · 3249822 · POSTING DATE: Apr 10, 2024 · PRIMARY LOCATION: Americas-United States of America-Massachusetts-Boston · EDUCATION LEVEL: Bachelor's Degree · JOB: Wealth Management · EMPLOYMENT TYPE: Full Time · JOB LEVEL: Non-Exempt ...
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Project Counsel
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Advanced Power Boston, United States**The Opportunity**: · Join a growing team dedicated to development and management of energy infrastructure, community economic development, corporate social responsibility, safeguarding environmental resources, and sharing in the growth of a highly ethical and competitive, priva ...
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Assoc Business Analyst
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Cybex Boston, United States**CYBEX** · **Job Position - Associate Business Analyst** · **Location - Downtown Boston, MA (On site)** · CYBEX is at the forefront of innovation, shaping the future of child safety with a keen eye on the evolving needs of modern parents. Our brand is synonymous with excellence, ...
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Director of Maintenance
2 weeks ago
UDR, Inc. Boston, United StatesUDR, Inc. is hiring a District Service Manager to join our team in Boston, MA. The position oversees the maintenance operations of three luxury apartment communities located in Boston City: 2 high rise communities in Seaport and South End and one midrise in Back Bay. · GENERAL SU ...
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M/S Tele Float Pool
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Trusted Health Salem, United StatesJob Description · Trusted is seeking an experienced nurse for this exciting travel nursing assignment. Trusted has streamlined the travel nursing experience by enabling nurses to apply directly to jobs without the need for recruiters. This unique approach provides more transparen ...
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Financial Monitoring Analyst
2 weeks ago
MA Gaming Commission Boston, United StatesThe Massachusetts Gaming Commission seeks to hire a Financial Monitoring Analyst. This position is responsible for working alongside various department staff to conduct financial monitoring and analysis of gaming and sports wagering operations on a monthly, quarterly, and annual ...
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Director,international Asia
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John Snow, Inc. and JSI Research & Training Institute, Inc. Boston, United States**Location**: Boston, MA or Arlington, VA · **Position Category**: Direct hire, paid in US · **Posting Date**: 05/19/2024 · **Deadline Date**: Open until the position is filled. · **Description**: · **Organization overview**: · JSI is a global nonprofit dedicated to improving peo ...
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Managers, Private Equity Performance Improvement
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Alvarez and Marsal Boston, United States**Description** · Work alongside other A&M professionals on the PEPI Supply Chain team to assist clients in analyzing each part of the supply chain process including Strategic Sourcing and Procurement, Logistics and Distribution, Integrated Demand and Supply Planning to identify ...
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Manager of Rental Underwriting
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MassHousing Boston, United States**Careers at MassHousing**: · At MassHousing, we believe a home is more than a roof and four walls. A home is safety and security, opportunity and peace of mind. Our team of talented professionals works to ensure that all Massachusetts residents have a safe, healthy and affordabl ...
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Family Partner
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Relationship Manager Iv
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Sales Support Specialist
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Cybex Boston, United States**Cybex** · **Job Position - Sales Support Specialist** · **Location - Downtown Boston, MA (On Site)** · CYBEX is at the forefront of innovation, shaping the future of child safety with a keen eye on the evolving needs of modern parents. Our brand is synonymous with excellence, s ...
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Director of Entertainment Operations
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Level99 Entertainment Boston, United StatesThe Director OF Entertainment Operations is responsible for all facets of entertainment operations, dedicated to delivering our elevated product offering in a positive, authentic, and inspiring environment for both guests and team members. The role is hands-on, in the trenches, w ...
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Compensation Manager
1 week ago
Bain Capital Boston, United StatesBAIN CAPITAL OVERVIEW · Bain Capital, LP is one of the world's leading private multi-asset alternative investment firms with approximately $155 billion of assets under management that creates lasting impact for our investors, teams, businesses, and the communities in which we liv ...
DMPK Principal Scientist, M&S Modeler - Boston, MA, United States - Vertex Pharmaceuticals
Description
Job Description We are currently seeking a highly skilled and motivated individual to provide quantitative modeling guidance and perform hands-on Quantitative systems pharmacology (QSP), PKPD and PBPK modeling for research and development programs at Vertex.In this role the qualified candidate will act as a lead preclinical PKPD modeling expert in interdisciplinary teams to support the drug discovery and development process by applying his/her knowledge and technical expertise to quantitatively characterize the pharmacokinetics, pharmacodynamics, and biomarker (PK/PD/Biomarker) properties of drug candidates. Quantitative understanding of the target and degree of modulation required for disease progression modification is necessary for setting human target exposure and desirable PK profiles. A thorough understanding of the biology, mechanism of action, efficacy biomarker and DMPK properties is essential for this individual to build mechanism-based mathematical models and update such models to incorporate new information throughout the lifespan of the projects. In addition, his/her core responsibilities also include PBPK modeling to integrate preclinical in vitro data for absorption and drug-drug interaction predictions. Prior experience with regulatory submissions of such PBPK DDI modeling work is highly desirable. The candidate may serve as a project team representative for discovery and development projects. Key Duties And Responsibilities