- Design, conduct, and manage both in house and CRO nonclinical studies, to characterize the ADME/PK of candidates to influence discovery decisions, and to support IND-enabling studies towards clinical development.
- Responsible for the analysis, interpretation, integration, and reporting of nonclinical DMPK-related data generated both internally and by CROs.
- Generation and interpretation of in vitro and in vivo ADME data in the context of allometric scaling, IVIVC/IVIVE
- Collaborate cross-functionally by representing the DMPK group in project teams, and by implementing ADME/PK lead optimization and candidate selection strategies that meet regulatory requirements and program goals.
- Prepare and deliver scientific presentations and reports to communicate research results within the project teams.
- Experience with pharmacokinetic-pharmacodynamic (PK/PD) modelling is desired.
- Title commensurate with experience.
- Doctorate degree in Pharmaceutical Sciences, Drug Metabolism, Pharmacokinetics, Biochemistry, or related discipline, or a BS/MS degree with a minimum of 5+ years of relevant experience in a pharmaceutical setting.
- The ideal candidate will have a track record of accomplishments (such as literature publications) demonstrating technical proficiency, independent thinking, and scientific creativity.
- Experience performing in vitro DMPK assays, such as metabolic stability, CYP inhibition, metabolite identification studies, and utilizing a mass spectrometer (LC-MS/MS) as the primary analytical tool. Strong consideration will be given to candidates proficient in using and troubleshooting an LC-MS/MS system.
- Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing impactful hypothesis-driven experiments.
- Strong knowledge of drug metabolism, PK, and physicochemical property principles
- Up to date knowledge of technological and regulatory advances in the DMPK functional area
- Knowledge in interpretation and hands-on analysis of PK and PK/PD data using Pheonix WinNonlin and/or other analyses software packages (GastroPlus, Sptofire, etc.)
- Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings, strong collaboration, and organizational skills.
- The successful candidate will be motivated to discover new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment.
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Associate Scientist/Scientist DMPK
2 weeks ago
Terremoto Biosciences South San Francisco, United StatesTerremoto Biosciences is looking for a talented Associate Scientist/Scientist, Drug Metabolism & Pharmacokinetics (DMPK). This individual will be responsible for planning, designing, conducting, and analyzing in vitro experiments to elucidate the ADME properties of molecules and ...
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Senior Scientist/Staff Scientist, DMPK
2 weeks ago
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native Complex Platform recapitulates GPCR ...
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senior scientist/staff scientist, dmpk
2 weeks ago
Septerna South San Francisco, CA, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native ComplexTM Platform recapitulates GP ...
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Senior Research Scientist I, DMPK
5 days ago
Gilead Sciences, Inc. Foster City, United StatesFor Current Gilead Employees and Contractors: · Please log onto your Internal Career Site to apply for this job. · At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - workin ...
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Senior Research Scientist I, DMPK
2 weeks ago
BioSpace Foster City, United StatesJob Details · Senior Research Scientist I, DMPK · United States - California - Foster City · Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discove ...
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Senior Research Scientist I, DMPK
2 weeks ago
Gilead Sciences, Inc. Foster City, United States Paid WorkFor Current Gilead Employees and Contractors: · Please log onto your Internal Career Site $) to apply for this job. · At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – wor ...
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BioSpace South San Francisco, United StatesJob Details · Company Description · AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key the ...
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AbbVie South San Francisco, United States Full time· Company Description · AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic ar ...
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Associate Director of DMPK
2 weeks ago
EPM Scientific San Francisco, United StatesI am partnered with a growing biotech company located in San Francisco who is looking for an Associate Director of DMPK to join their team This company currently has 8 candidates in their preclinical pipeline and 2 clinical candidates across metabolic, neuro, ophthalmology, and c ...
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Associate Director, DMPK
9 hours ago
Third Rock Ventures San Francisco, United StatesThe Position: · Are you ready to take the helm of discovery efforts in our DMPK group at Maze? As an Associate Director, you'll be at the forefront of driving our mission forward, supporting discovery projects from hit-to-lead (H2L) through investigational new drug (IND) phases. ...
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Associate Director, DMPK
2 weeks ago
Oric Pharmaceuticals, Inc. San Francisco, United StatesWe are seeking a highly motivated Senior Principal Scientist/Associate Director specialized in characterizing the in vitro and in vivo ADME/PK properties of small molecule lead compounds and drug candidates. This person will work on ORIC drug discovery and development project tea ...
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Third Rock Ventures San Francisco, United StatesTerremoto Biosciences is looking for a talented Associate Scientist/Scientist, In Vivo Pharmacology. This individual will be responsible for planning, designing, conducting, and analyzing in vivo experiments to support the progression of multiple programs. The position would be a ...
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Advisor, Medicinal Chemistry
6 days ago
Eli Lilly and Company San Francisco, United States Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
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Advisor, Medicinal Chemistry
2 weeks ago
BioSpace San Francisco, United StatesJob Details · At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need th ...
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Advisor, Medicinal Chemistry
2 weeks ago
Eli Lilly and Company San Francisco, CA, United StatesAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
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Senior Director, Clinical Pharmacology
2 weeks ago
Third Rock Ventures San Francisco, United StatesAt Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Sci ...
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Client Relationship Manager
17 hours ago
Genesis Global Group San Francisco, United StatesJob Summary : · Genesis Drug Discovery and Development (GD3), a member of the Genesis Biotechnology Group, is a fully integrated CRO providing services to support drug discovery/development programs of our clients from target discovery through IND filing and managing Phase I-IV ...
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General Proximity San Francisco, United Statestl;dr · General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to ...
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Director, DMPK
6 days ago
Eli Lilly and Company San Francisco, United States Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
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Executive Director, Immunology
5 days ago
BioSpace San Francisco, United StatesJob Details · At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need th ...
Senior Scientist/Staff Scientist, DMPK - San Francisco, United States - Third Rock Ventures
Description
We are seeking a talented scientist to join our Clinical Pharmcology and Drug Metabolism and Pharmacokinetics (CP&DMPK) group.This role focuses on broad support for our drug discovery programs, by contributing to overall lead optimization and development candidate identification execution and strategies.
The successful candidate will become a scientific contributor within our R&D organization, impacting drug discovery across all projects.This will be an outstanding opportunity to collaborate with talented colleagues who all share a passion for developing safe and efficacious therapeutics for patients.
Key responsibilities include:
Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training.
Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Note to Employment Agencies:
Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
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