- Design, conduct, and manage both in house and CRO nonclinical studies, to characterize the ADME/PK of candidates to influence discovery decisions, and to support IND-enabling studies towards clinical development.
- Responsible for the analysis, interpretation, integration, and reporting of nonclinical DMPK-related data generated both internally and by CROs.
- Generation and interpretation of in vitro and in vivo ADME data in the context of allometric scaling, IVIVC/IVIVE
- Collaborate cross-functionally by representing the DMPK group in project teams, and by implementing ADME/PK lead optimization and candidate selection strategies that meet regulatory requirements and program goals.
- Prepare and deliver scientific presentations and reports to communicate research results within the project teams.
- Experience with pharmacokinetic-pharmacodynamic (PK/PD) modelling is desired.
- Title commensurate with experience.
- Doctorate degree in Pharmaceutical Sciences, Drug Metabolism, Pharmacokinetics, Biochemistry, or related discipline, or a BS/MS degree with a minimum of 5+ years of relevant experience in a pharmaceutical setting.
- The ideal candidate will have a track record of accomplishments (such as literature publications) demonstrating technical proficiency, independent thinking, and scientific creativity.
- Experience performing in vitro DMPK assays, such as metabolic stability, CYP inhibition, metabolite identification studies, and utilizing a mass spectrometer (LC-MS/MS) as the primary analytical tool. Strong consideration will be given to candidates proficient in using and troubleshooting an LC-MS/MS system.
- Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing impactful hypothesis-driven experiments.
- Strong knowledge of drug metabolism, PK, and physicochemical property principles
- Up to date knowledge of technological and regulatory advances in the DMPK functional area
- Knowledge in interpretation and hands-on analysis of PK and PK/PD data using Pheonix WinNonlin and/or other analyses software packages (GastroPlus, Sptofire, etc.)
- Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings, strong collaboration, and organizational skills.
- The successful candidate will be motivated to discover new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment.
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Senior Scientist/Staff Scientist, DMPK - South San Francisco, United States - Septerna
Description
The Company
Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients.
This approach enables access for the first time to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs.
Septerna has an emerging pipeline of GPCR-targeted small molecule programs with growth potential to reach many GPCRs that have been undruggable and unexploited to date.
Septerna was launched by scientific founders who have made groundbreaking GPCR discoveries and by founding investor Third Rock Ventures.For more information see:
Join a multidisciplinary team of colleagues focused on creating revolutionary medicines to address significant needs of patients.
Bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals, and contribute your passion, creativity, and energy to our mission.
At Septerna we embrace diversity of thought, expertise, and background.We share a fearless pursuit of ground-breaking innovations, and our employees learn from each other and succeed as a team.
THE ROLE
We are seeking a talented scientist to join our Clinical Pharmcology and Drug Metabolism and Pharmacokinetics (CP&DMPK) group.
This role focuses on broad support for our drug discovery programs, by contributing to overall lead optimization and development candidate identification execution and strategies.
The successful candidate will become a scientific contributor within our R&D organization, impacting drug discovery across all projects.This will be an outstanding opportunity to collaborate with talented colleagues who all share a passion for developing safe and efficacious therapeutics for patients.
Key responsibilities include:
Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training.
Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Note to Employment Agencies:
Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
