- Design, conduct and interpret in vitro experiments to profile ADME properties of drug candidates.
- Conduct and/or design hypothesis driven in vitro and in vivo studies to reveal the mechanism of drug disposition.
- Provide interpretation of in vitro, ex vivo and in vivo data that are generated both internally and with CROs; review and interpret bioanalytical data and reports; establish exposure-response relationships.
- Participate and contribute to project team meetings and presentations; represent DMPK as the subject matter expert and draft DMPK screening strategy.
- Manage and mentor scientists, including problem-solving for methods and instrumentation.
- Coauthor and review high quality regulatory documents and DMPK study reports.
- Participate in the preparation of abstracts, posters, and manuscripts for publication.
- PhD and PostDoc in Pharmacokinetics, Chemistry, Drug Metabolism, Pharmaceutical Sciences or other relevant field with 10+ years of industry experience.
- Strong scientific and technical knowledge in ADME profiling, drug metabolism, transport, SAR analysis and PK; hands on experience in operation and troubleshooting of HPLC and high-resolution mass spectrometers preferred.
- Experience in performing PK analysis using Phoenix or similar; experience with PBPK modeling a plus.
- Significant experience in PK/PD analysis, data interpretation and simulation.
- Proficiency in managing collaborations with CROs.
- Track record in mentoring and managing direct reports
- Effective in multidisciplinary project teams and enjoys interacting with colleagues across functions.
- Excellent oral and written communication skills.
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Director, DMPK
5 days ago
Eli Lilly and Company San Francisco, United States Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
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Director, DMPK
2 weeks ago
Eli Lilly and Company San Francisco, CA, United StatesAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
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Director, Dmpk
2 days ago
Evommune, Inc. Palo Alto, United States**ABOUT EVOMMUNE** · This position is currently expected to be in the office 2 days a week with the option of working remotely 3 days a week. Currently, most Evommune employees attend the office on Tuesdays and Wednesdays (at a minimum). The position reports to the Executive Dire ...
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Associate Director of DMPK
2 weeks ago
EPM Scientific San Francisco, United StatesI am partnered with a growing biotech company located in San Francisco who is looking for an Associate Director of DMPK to join their team This company currently has 8 candidates in their preclinical pipeline and 2 clinical candidates across metabolic, neuro, ophthalmology, and c ...
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Director of DMPK
1 week ago
EPM Scientific South San Francisco, United StatesOverview: · We are seeking a highly skilled professional to provide comprehensive guidance on clinical pharmacology initiatives that support drug discovery and development. This role involves authoring clinical protocols, analyzing data (exposure, efficacy, safety), and contribut ...
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Director, DMPK
5 days ago
Evommune, Inc. Palo Alto, United StatesJob Description · Job DescriptionABOUT EVOMMUNE · Evommune, Inc., a Palo Alto based biotech company, is creating game-changing science to treat immune-mediated inflammatory diseases by discovering, developing, and delivering therapies that address symptoms and halt progressive di ...
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Director, DMPK
3 weeks ago
Evommune, Inc. Palo Alto, CA, United StatesABOUT EVOMMUNE · Evommune, Inc., a Palo Alto based biotech company, is creating game-changing science to treat immune-mediated inflammatory diseases by discovering, developing, and delivering therapies that address symptoms and halt progressive disease. For more information, vis ...
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Associate Director, DMPK
1 week ago
ORIC Pharmaceuticals Inc South San Francisco, United States· We are seeking a highly motivated Senior Principal Scientist/Associate Director specialized in characterizing the in vitro and in vivo ADME/PK properties of small molecule lead compounds and drug candidates. This person will work on ORIC drug discovery and development project ...
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IDEAYA Biosciences, Inc. San Francisco, United StatesIDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates ext ...
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Associate Director, DMPK
3 weeks ago
EPM Scientific South San Francisco, United StatesI am partnered with a growing biotech company located in San Francisco who is looking for an Associate Director of DMPK to join their team This company currently has 8 candidates in their preclinical pipeline and 2 clinical candidates across metabolic, neuro, ophthalmology, and c ...
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Associate Director, DMPK
2 weeks ago
Mazetx South San Francisco, United StatesWe are a passionate, curious, creative and motivated team of genetic navigators and industry veterans excited to discover and progress next generation precision medicines to change the course of disease. · At Maze, we are building a culture that encourages vision, initiative and ...
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BioSpace South San Francisco, United StatesJob Details · IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach ...
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IDEAYA Biosciences South San Francisco, United States Full timeIDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates ext ...
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Alumis South San Francisco, United StatesJob Description · Job DescriptionSalary: · Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to su ...
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Alumis Inc South San Francisco, United StatesAlumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change t ...
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BioSpace South San Francisco, United StatesJob Details · Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamen ...
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Clinical Pharmacology, Director
4 days ago
89bio, Inc. San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically e ...
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89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
Associate Director, DMPK - San Francisco, United States - Oric Pharmaceuticals, Inc.
Description
We are seeking a highly motivated Senior Principal Scientist/Associate Director specialized in characterizing the in vitro and in vivo ADME/PK properties of small molecule lead compounds and drug candidates.
This person will work on ORIC drug discovery and development project teams with the goal of developing therapeutics to overcome resistance in cancer.
The primary responsibilities will be to plan, oversee and/or execute in vitro and in vivo studies, interpret results and troubleshoot problems as well as establish exposure-response relationships to inform PK drivers of efficacy.
The successful candidate will thrive in partnership with discovery and development teams to identify clinical candidates and support regulatory filings, as well as manage and mentor team members.
Essential duties:
Education and Experience:
The anticipated salary range for candidates who will work in our South San Francisco location is between $185,000- $220,000.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.
ORIC Pharmaceuticals, Inc. is an equal opportunity employer.ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristic.
Associate Director, DMPK professionals in San Francisco
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Truc Thien Nguyen-Pham
Project Manager
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Michelle Sjöberg
Michelle Sjöberg is a multidisciplinary creative with over 10 years of experience as an art director ...