Jobs
>
Seattle

    Senior Engineer, Cell Therapy Process Development - Seattle, United States - Sana Biotechnology, Inc.

    Sana Biotechnology, Inc.
    Sana Biotechnology, Inc. Seattle, United States

    4 weeks ago

    Default job background
    Description
    Senior Engineer, Cell Therapy Process Development / MSAT


    Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas.

    As a Senior Process Engineer, you will report to the Sr.

    Director of Cell Therapy Process Development and drive the development of a novel allogeneic chimeric antigen receptor T (CAR T) cell manufacturing process.

    The Sr.

    Process Engineer will serve as the process subject matter expert, lead development, and coordinate the integration of multiple unit operations including cell isolation and expansion, gene editing, lentiviral transduction, and cryopreservation.

    The candidate will lead a multidisciplinary group of up to 2 engineers and research associates to execute the development plan and support manufacturing campaigns.

    This role will collaborate closely with multiple cross-functional teams including Analytical Development, Research, Supply Chain and External Manufacturing to coordinate critical deliverables.

    The individual will also maintain a focus on innovation and process improvements to develop next generation allogeneic T cell manufacturing processes.

    What you'll do
    Serve as process SME for an allogeneic CAR T cell program
    Define process development strategy in close collaboration with the CMC and Process Leads.
    Lead the execution of the allogeneic CAR T cell therapy process development plan
    Mentor, train, and motivate a group of engineers and research associates to plan, execute and analyze experiments
    Provide expert technical opinions to justify process development decisions
    Draft, review, and approve technical documentation including reports, process descriptions, SOPs, and MBRs
    Support internal and external process transfers
    Draft technical sections to support regulatory filings
    Evaluate new bioprocess technologies and implement process advancements for introduction into a GMP manufacturing environment
    Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
    Demonstrate the ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
    Drive curiosity, scientific rigor, and excellent problem-solving skills across a fast-paced performance driven environment
    Innate ability to assess talent that will help grow the organization and add to Sana's culture
    What we're looking for
    PhD. in Chemical, Biological or Biomedical Engineering plus 2 years of industry experience or equivalent. BA and/or MS plus 7+ yrs or equivalent combination of education and work experience.
    >2 year of progressive experience in cell therapy process development, preferably with clinical and commercial stage T cell therapy processes with focus on cell culture
    Proven ability to lead a team of junior engineers and research associates
    Experience designing and scaling key cell therapy unit operations, especially T cell cultures within bioreactors
    Strong track record of applying fundamental engineering and scientific principles to process design, modeling, and characterization
    Well versed with cGMP requirements and working in a regulated environment
    Advanced knowledge of immunology including T cell biology
    Working knowledge of statistical design of experiments (DoE)
    Excellent technical written and oral communication skills
    Effective collaborator with an agile mindset to thrive in a fast-paced, multi-site, team-oriented organization
    Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment
    What will separate you from the crowd
    Experience with T cell isolation, lentiviral transduction, gene editing, cell harvest and cryopreservation unit operations design and scaling
    Well versed with current cell therapy manufacturing platforms
    Experience selecting raw materials and equipment suitable for cell therapy processes
    Familiarity applying PAT to cell therapy
    Proficient with relevant analytical methods including flow cytometry and cell-based assays
    Knowledge designing high throughput T cell culture scale down models
    Familiar with R, Python, JMP and FlowJo software
    Demonstrate intense technical curiosity and a continuous drive to learn new skills
    What you should know
    The base pay range for this position at commencement of employment is expected to be between $140,000 and $160,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience
    This position requires handling of healthy donor human blood products
    Approximately 50% in-lab work
    Travel up to 25% of the time
    How we work together
    Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
    Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
    Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution
    Get to know us

    At Sana,we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases.

    This belief is a pillar of our business and is critical to our success.

    Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

    Core to our values, we believe there is nothing more important than the health and wellness of you and your family.

    For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off (various paid time off benefits, such as holidays,vacation, sick time, and parental leave), short- and long-term disability, employer paid basic life insurance, additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.

    For more details on our benefits, visit Sana's Benefits Portal

    .

    We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

    To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.

    #J-18808-Ljbffr
  • Kelly Services, Inc.

    Director of Cell Therapy Process Development

    4 weeks ago

    Kelly Services, Inc. Seattle, United States

    #x 9; Lead and manage a Seattle based team of cellular therapy process development subject matter experts. (SME) that provide technical support by participating on project teams. Works with the cross functional operations team to meet timelines for f Director, Development, Techni ...

  • Sunrise Systems Inc

    Upstream Process Development Research Scientist

    3 weeks ago

    Sunrise Systems Inc Seattle, United States

    Top Skills: · 2+ years of hands-on lab work on biotech industry · Experience in process development: Upstream process development and/or mammalian cell culture OR Downstream process development/purification · Bachelor's degree in STEM field · Job Description · The senior res ...

  • Sana Biotechnology, Inc.

    Executive Director, PSC Process Development

    2 days ago

    Sana Biotechnology, Inc. Seattle, United States

    Executive Director, PSC Process Development · Cambridge, MA; Seattle, WA; South San Francisco, CA February 01, 2024 · Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status qu ...

  • Icosavax, Inc.

    Research Associate II, Process Development

    2 weeks ago

    Icosavax, Inc. Seattle, United States

    Research Associate II, Process Development · summary: icosavax, inc., a member of the astrazeneca group (lse/sto/nasdaq: azn), is a biopharmaceutical company focused on developing differentiated, high-potential vaccines using an innovative, protein virus-like particle (vlp) plat ...

  • Sana Biotechnology, Inc.

    Executive Director, PSC Process Development

    5 days ago

    Sana Biotechnology, Inc. Seattle, United States

    Executive Director, PSC Process Development · Cambridge, MA; Seattle, WA; South San Francisco, CA February 01, 2024 · Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo ...

  • Icosavax, Inc.

    Research Associate II, Process Development

    2 weeks ago

    Icosavax, Inc. Seattle, United States

    Research Associate II, Process Development · summary: icosavax, inc., a member of the astrazeneca group (lse/sto/nasdaq: azn), is a biopharmaceutical company focused on developing differentiated, high-potential vaccines using an innovative, protein virus-like particle (vlp) plat ...

  • Sana Biotechnology, Inc.

    Senior Engineer, Cell Therapy Process Development

    3 weeks ago

    Sana Biotechnology, Inc. Seattle, United States

    About the role · Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Senior Process Engineer, you will report ...

  • BioSpace, Inc.

    Senior Engineer, Cell Therapy Process Development

    4 weeks ago

    BioSpace, Inc. Seattle, United States

    Job Details · About the role · Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Senior Process Engineer, y ...

  • Group14 Technologies

    Process Development Engineer

    2 weeks ago

    Group14 Technologies Woodinville, United States

    Job Description · Job DescriptionSalary: $100,000 - $120,000 base salary · Founded to enable the coming electrification of everything, Group14 is the largest commercial manufacturer and supplier of advanced silicon battery technology, elevating performance for every type of batte ...

  • Group14 Technologies

    Process Development Engineer

    21 hours ago

    Group14 Technologies Woodinville, United States

    Job Description · Job DescriptionSalary: $100,000 - $120,000 base salary · Founded to enable the coming electrification of everything, Group14 is the largest commercial manufacturer and supplier of advanced silicon battery technology, elevating performance for every type of batte ...

  • Pfizer

    Scientist, Conjugation Process Development

    2 weeks ago

    Pfizer Bothell, United States Part time, Full time

    Why Patients Need You · Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Wh ...

  • Titan Industries

    Digitalization Business Developer

    1 week ago

    Titan Industries Sun, United States

    About the Company · Our company is a subsidiary of one of the leading manufacturers in the outdoor, ski, and sportswear industry. · With over 200 years of expertise in functionality, quality, and production, our parent company's knowledge is also reflected in our work and corpora ...

  • Infinity Technologies

    IT Recruiter

    1 week ago

    Infinity Technologies Sun City West, United States

    Job ID: 1209 · With your expertise, we are recruiting IT talents who are passionate about using their knowledge and skills at Thieme to improve medicine and promote better health in people's lives. · Thieme is a leading provider of information and services that contribute to impr ...

  • Spectrum Ventures

    Dual study program in Electrical and Information Engineering with in-depth practical experience

    1 week ago

    Spectrum Ventures King, United States

    In your dual study program with practical training, you will learn step by step everything you need to know within 3.5 years to: * Configure electrical systems * Develop and program software * Design infrastructure and automation systems, including process visualization At the un ...

  • Aurora Ventures

    Technical Purchaser

    1 week ago

    Aurora Ventures King City, United States

    We are a leading company for raw materials in the food, beverage, pharmaceutical, and animal feed industries and are currently seeking a full-time Technical Purchaser (m/f/d) to join our team in King City as soon as possible. · Your responsibilities: · Management of our fleet, in ...

  • Eclipse Enterprises

    Production specialist in the electronics sector

    1 week ago

    Eclipse Enterprises King City, United States

    Production Specialist in the field of electronics/mechatronics/microtechnology (m/f/d) Shift Leader Berlin Full-time Permanent We are looking for a motivated and experienced shift leader for our manufacturing company in King City. As a shift leader, you will be responsible for th ...

  • Group14

    Process Development Engineer

    2 weeks ago

    Group14 Woodinville, United States

    Founded to enable the coming electrification of everything, Group14 is the largest commercial manufacturer and supplier of advanced silicon battery technology, elevating performance for every type of battery application. With headquarters in Woodinville, WA, Group14 enables batte ...

  • Group14 Technologies

    Process Development Engineer

    3 weeks ago

    Group14 Technologies Woodinville, United States

    Job Description · Job Description Salary: $100,000 - $120,000 base salary · Founded to enable the coming electrification of everything, · Group14 · is the largest commercial manufacturer and supplier of advanced silicon battery technology, elevating performance for every type ...

  • Pfizer

    Senior Scientist, Conjugation Process Development

    2 weeks ago

    Pfizer Bothell, United States Part time, Full time

    Why Patients Need You · Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Wh ...

  • BlueHorizon Solutions

    Warehouse Specialists

    1 week ago

    BlueHorizon Solutions King Lake, United States

    Join our team at FISLAGE Flexibles GmbH We are a medium-sized company in the paper processing industry with 140 employees at two locations in Germany. We develop and produce a wide range of creped or coated products, as well as corrosion protection products and composites for the ...