Postdoctoral Fellow-MSH-30001-303 - New York, United States - Mount Sinai Hospital

Description

Job Description

Postdoctoral Fellow in Microglia Biology and Neuroimmunology of Alzheimer's Disease
Availability
Immediately available, NIH funded
Description
The Alison Goate's laboratory in the Departments of Genetics and Genomic Sciences and of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York City is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to translate the human genetics of Alzheimer's disease (AD) into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the Goate lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular, and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions. In addition, the Goate lab also investigates how the human genetics of the 17q21.31 "MAPT/tau" locus contributes to mechanisms underlying Tauopathy, and translating this work into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into in vitro (induced pluripotent stem cell models) models to understand the role of 17q21.31 on disease pathogenesis. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer's Disease, as well as at other leading US and European academic institutions and biopharmaceutical companies.

Responsibilities

Qualifications and Skills

• Ph.D. in Biology, Neuroscience, Immunology, or related field with deep expertise in molecular and cellular biology techniques
• Strong research experience in microglia/macrophage biology (preferred)
• Strong research experience in mouse microglia/macrophage biology in vivo (preferred)
• or -
• Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred)
• or -
• Strong research experience in high-throughput technologies (e.g., NGS and CyTOF) for bulk and single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred)
• or -
• Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9, and chemogenomic) screens (preferred)
• Knowledge of experimental design
• Statistical and quantitative analysis skills
• Basic bioinformatics skills (preferred)
• Self-motivated and highly dedicated
• Effective organizational and prioritization skills
• Effective oral, written, and interpersonal communication skills
• Ability to work both independently as well as collaboratively in a multidisciplinary environment

Qualifications

Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet were as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinais unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.

We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care.

Explore more about this opportunity and how you can help us write a new chapter in our story

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression.

Non-Bargaining Unit, 816 - Genetics/Genomic Sci - ISM, Icahn School of Medicine

About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

We work hard to acquire and retain the best people and to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to professional advance. We share the belief that all employees, regardless of job title or expertise contribute to the patient experience and quality of patient care.

Explore more about this opportunity and how you can help us write a new chapter in our history

"About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism."

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