- Owns the assay development and execution of PK and ADA assays while capable of recommending methods, techniques and evaluation criteria for obtaining results
- Communicates effectively PK development progress with project teams while keeping timelines at top of mind
- Collaborates with the broader research team to design and analyze internal mouse PK studies that answer questions relating to mechanism of action
- Works in unison with the development and research teams to evaluate DMPK properties of lead molecules as they relate to modes of administration and molecular design
- Supports non-GLP preliminary animal toxicity studies to enable lead candidate selection
- Provides critical insights into internal PK study designs and modes of drug administration, driving decisions that propel our programs forward
- Capable of working on problems with a diverse scope that requires analysis and data review
- Thinks critically to uncover identifiable factors relating to PK, PK/PD, ADA and TK studies
- Interacts on a technical level with CROs in the areas of PK /ADA assay development, with an eye towards validation, and sample processing
- Candidate should possess strong assay development skills
- Direct industrial experience in the application of PK /pharmacometrics preferably within the context of biologics
- Working knowledge and application of hands-on skills in PK/PD modeling of pre-clinical data
- Experience in conducting TK analysis in support of non-GLP exploratory toxicology studies
- A deep understanding of PK and ADA assay development principles and techniques (ELISA, MSD, BLI, SPR, MS, %recovery, precision & accuracy)
- Thorough comprehension of fundamental PK, ADA, and quantitative pharmacology (PK/PD) principles such as half-life calculations, clearance, Cmax, titers etc.
- Able to work both collaboratively and independently while multi-tasking, prioritizing, and completing assignments in a timely and occasionally accelerated manner
- Adaptable to potential revisions with study designs on a short notice
- Familiarity with PK modeling tools to empower extraction of meaningful insights is a plus
- MS in Pharmacology / Biochemistry or related discipline with 4-6 years of industry (biotech/pharmaceutical) experience or BS with 7-8 years of experience
-
Director, Assay Development
2 days ago
Quanterix Billerica, United States**What You'll Do**: · - Develop best-in-class ultrasensitive immunoassays that increase value of Simoa assay portfolio. · - Lead, mentor and inspire high-performing team of assay development scientists to meet new product launch and quality objectives for Simoa assays. · - Manage ...
-
Scientist, NGS Assay Development
1 week ago
Sana Biotechnology Cambridge, United States Full timeAbout the role · Sana Biotechnology is developing the next generation of gene and cell therapies, and we are looking for a highly motivated Scientist to join our Analytical Genomics group. As a Scientist, you will report to Director NGS Assay Development at Cambridge to develop ...
-
Sr Scientist, Assay Development
1 week ago
Foundation Medicine Boston, United States Full timeAbout the Job · The Senior Scientist, Assay Development will work as part of a new product team, focused on improving blood-based cancer diagnostic capabilities in areas such as cancer detection, minimum residual disease, and other related applications. This team is comprised of ...
-
Infectious Disease Assay Development Ra
1 week ago
Kephera Diagnostics Framingham, United StatesResponsibilities will include, but are not limited to the following: · - Performance of laboratory experiments using a variety of biochemical and immunological methods and protocols. · - Cell culture, production of native and recombinant proteins. · - Documentation of experimenta ...
-
Scientist/Senior Scientist, Assay Development
2 weeks ago
Droplet Biosciences, Inc Cambridge, United StatesDroplet Biosciences is seeking a scientist/senior scientist to join the assay development team in the development of novel lymph biopsy tests. The assay development team leverages advanced -omic technologies and works cross-functionally to deliver early and sensitive diagnostics ...
-
Director, Assay Development
3 days ago
Quanterix Billerica, United StatesJob Description · Job DescriptionDIRECTOR, ASSAY DEVELOPMENT · BILLERICA, MA · Quanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to ch ...
-
Director, Assay Development
1 week ago
Quanterix Billerica, United StatesJob Description · Job DescriptionQuanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to change the way in which healthcare is provided t ...
-
Scientist, CMC Biological Assay Development
1 week ago
enGene Waltham, United StatesTHE COMPANY · enGene is a late-stage biotechnology company mainstreaming genetic medicines through the delivery of therapeutics to mucosal tissues and other organs, whose lead program EG-70 is being evaluated in an ongoing pivotal study for patients with non-muscle invasive bladd ...
-
Garuda Therapeutics Cambridge, United StatesGaruda Therapeutics is pioneering the development of off-the-shelf hematopoietic stem cell (HSC)-based cellular therapies for treating patients with blood, bone marrow, immune, and metabolic disorders. The company uses state-of-the-art technologies in developmental biology, gene- ...
-
Garuda Therapeutics, Inc. Cambridge, United StatesJob Description · Job DescriptionGaruda Therapeutics is pioneering the development of off-the-shelf hematopoietic stem cell (HSC)-based cellular therapies for treating patients with blood, bone marrow, immune, and metabolic disorders. The company uses state-of-the-art technologie ...
-
Research Associate, Assay Development
3 days ago
Quanterix Billerica, United StatesJob Description · Job DescriptionResearch Associate, Assay Development · Billerica, Ma · Quanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the poten ...
-
Spear Bio Woburn, United StatesJob Description · Job DescriptionSalary: · Spear Bio is a well-funded and rapidly growing start-up company based in Woburn, Massachusetts. We are focused on bringing to market a novel ultrasensitive immunoassay platform able of work with very small sample volumes. The commercial ...
-
Research Associate, Assay Development
1 week ago
Quanterix Billerica, United StatesResearch Associate, Assay Development · Billerica, Ma · Quanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to change the way in which h ...
-
Senior Scientist, Assay Development X2
1 week ago
Quanterix Billerica, United StatesQuanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to change the way in which healthcare is provided today by giving researchers the ab ...
-
Senior Scientist, Assay Development X2
3 days ago
Quanterix Billerica, United StatesJob Description · Job DescriptionQuanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to change the way in which healthcare is provided t ...
-
Scientist, Translational Pathology
1 week ago
Bristol-Myers Squibb Cambridge, United States**Working with Us** · Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production ...
-
Moderna Cambridge, United StatesThe Role · Here's What You'll Do · Develop and qualify HPLC-UV and LC-MS-based enzyme activity assays for the detection of small molecules. · Develop and qualify plate-based fluorometric/colorimetric assays for the detection of small molecules. · Develop and qualify cell-based as ...
-
Research Associate
1 week ago
Pinetree Therapeutics Cambridge, United States**About the Company** · Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of ...
-
Scientist, Antibody Engineering
3 days ago
Moderna Cambridge, United States**The Role**: · **Here's What You'll Do**: · Develop new methods for discovery of antibodies from immune repertoires (e.g. human, mouse, llama) · Lead antibody characterization and down-selection campaigns to identify lead therapeutics molecules · Develop and perform methods for ...
-
Head, Clinical Pharmacology
3 days ago
Leap Therapeutics Cambridge, United States**Head, Clinical Pharmacology**: · **Company Summary**: · **General Responsibilities**: · ***The Head of Clinical Pharmacology will be responsible for developing and executing the clinical and non-clinical pharmacology strategies for compounds from the pre-clinical stage through ...
Scientist II, In Vitro Assay Development - Cambridge, United States - Anokion
Description
Job Description
Job DescriptionAbout Us
Anokion SA is a clinical-stage biotechnology company that aims to make a meaningful difference in the lives of patients suffering from autoimmune diseases by restoring normal immune tolerance.
The company is focused on both prevalent and rare autoimmune diseases, including celiac disease, multiple sclerosis, and type 1 diabetes.
Anokion's distinct approach leverages the company's immune-based platform, which targets natural pathways in the liver to restore immune tolerance and address the underlying cause of autoimmune disease.
For more information, please visitJob Summary
This position is responsible for designing, developing, and utilizing PK and ADA assays for internal studies or CRO transfer.
This individual will also weigh in on internal PK study designs and modes of drug administration studies that will help advance preclinical, and clinical programs.
The candidate should have a strong working knowledge of PK, ADA, PK/PD principles and TK relationships with application to pre-clinical animal tolerability and efficacy.
This position requires strong pharmacometrics skills combined with biological understanding and assay development skills to enable the team to conduct PK modeling studies.
The applicant should possess strong communication skills, an understanding of the drug development process, and experience leading from within while collaborating effectively as a member of a cross-functional team.
Responsibilities and Duties
Qualifications
Anokion is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.
Powered by JazzHR
gojPMtOy0d
