Scientist, Translational Pathology - Cambridge, United States - Bristol-Myers Squibb

Bristol-Myers Squibb
Bristol-Myers Squibb
Verified Company
Cambridge, United States

2 weeks ago

Mark Lane

Posted by:

Mark Lane

beBee recruiter
Description

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department.

From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity.

Take your career farther than you thought possible.


This is an exciting opportunity to advance our precision medicine efforts by developing tissue-based assays to support patient selection strategies.

Applicants chosen for this position will directly interact with diverse clinical and scientific colleagues to advance cutting-edge clinical trials programs.

Projects include development of assays using immunohistochemistry, multiplex staining/imaging, in situ nucleic acid hybridization, and digital pathology.

The scientist will be directly responsible for the design, development, execution, and analysis of translational tissue-based biomarker assays to interrogate target prevalence, target engagement, mechanisms of action, pharmacokinetics, pharmacodynamics, -and prediction of treatment response.

The position entails working on projects independently and in multi-disciplinary teams consisting of pathologists, lab scientists, data scientists and clinical biomarker scientists.

The IHC scientist will develop tissue-based assays for internal or external use with accountability for assays transferred to partner labs and contract research organizations (CROs).

The scientist will also be responsible for working with digital pathology colleagues to build and assess image analysis algorithms and workflows.


CORE JOB FUNCTION(S):


  • The scientist will coordinate and perform all aspects of assay development spanning project intake, planning, development and execution of assays including (but not limited to) chromogenic immunohistochemistry (IHC), insitu nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology
  • Development of assay workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues
  • Responsible for planning, coordination, and execution of assay transfer to vendor sites with communication/problem solving with the vendor
  • Maintain technical proficiency across several IHC, mIF, histology/tissue processing and digital scanner technologies
  • Provide concise yet thorough project overviews and timelines to leadership and stakeholders
  • Contribute to design control processes and CAP/CLIA lab work, documentation, and planning (when needed)
  • Coordinate, execute and document clinical trial sample and commercial sample assay development and deployment within BMS labs
  • Capable of working on multiple development projects simultaneously with appropriate project prioritization while also participating in lab management and other lab initiatives
  • Perform preliminary scoring of stained slides with the engagement of pathologist oversight and review
  • Digital image analysis for assay quality assessment and analysis
  • Maintain workplace and lab compliant processes and documentation
  • Mentoring and coaching less experienced scientists
  • Familiar/keeps current with literature
  • Promotes responsible fiscal practices throughout the lab
  • Participates in continuous improvement or development of new/improved work practices
  • Suggests approaches to new ways of working and to improve efficiency
  • Moves forward independently to the next logical step of an experiment
  • Troubleshoots routine technical problems
  • May participate in complex programs/projects within the division
  • Capable of meeting deadlines on an independent book of work
  • Suggests options to solve complex problems leveraging technical and operational expertise
  • Works under limited supervision; reviews work regularly with supervisor/pathologist
  • Decisions impact work group/project team
  • Proactively promotes and engages in the exchange of ideas, information, and feedback within own group
  • Initiates internal subgroups with peers to accomplish goals
  • May act as point of contact for a program within own group
  • Develops and maintains strong working relationships with colleagues
  • Makes presentations in small group meetings with multidisciplinary stakeholders
  • This is a labbased position requiring onsite work >80% of the time (averaged across 2 weeks)

Basic Qualifications:


  • Bachelor's Degree with 5+ years of academic and / or industry experience
    OR master's degree with 3+ years of academic and / or industry experience
    OR Ph.
D. or equivalent advanced degree in the Life Sciences


Preferred Qualifications:


  • Research experience in the field of cancer biology and immunology
  • Experienced in the design a
More jobs from Bristol-Myers Squibb
See all jobs of Bristol-Myers Squibb