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    Research Associate I - San Diego, United States - Capstan Therapeutics

    Capstan Therapeutics
    Capstan Therapeutics San Diego, United States

    3 weeks ago

    Default job background
    Pharmaceutical / Bio-tech
    Description

    About Capstan Therapeutics

    Capstan Therapeutics, Inc. is a privately held biotechnology company dedicated to advancing in vivo cell reprogramming. The core platform technology comprises proprietary targeted lipid nanoparticles (tLNPs) that are composed of LNPs conjugated with a recombinant protein binder, such as a monoclonal antibody. tLNPs are designed to deliver payloads, including mRNA or gene editing tools, capable of reprogramming specific cell types in vivo. The platform technology has the potential to generate transformative therapies with possible applications across a broad range of disease areas, including oncology, autoimmune disorders, fibrosis, and monogenic blood disorders.

    The Opportunity

    We are currently searching for a highly motivated Research Associate I or Senior Research Associate to join our growing Formulation and Process Development team. In this role, you will directly work on formulation and process development of our cutting-edge CAR-tLNP drug product to support emerging research pipelines focused on oncology, fibrosis and inflammation-related diseases, and blood monogenic disorders.

    This position will report to the Manager of Formulation and Process Development and is based at our San Diego office. This role will involve hands-on laboratory work. All duties will be performed in compliance with Capstan's standard operating procedures (SOPs).

    Responsibilities & Duties:

    • Prepare, formulate, and characterize complex, nucleic acid-based lipid nanoparticle formulations in a consistent, reproducible manner.
    • Fulfill varied production requests from internal teams to support various ongoing drug product pipelines.
    • Develop the formulation and purification process for lipid nanoparticle based nucleic acid formulations with targeting modalities, as well as scaling up of the process.
    • Perform investigations of aberrant results, determine the root cause(s), and recommend an action plan to ensure process robustness.
    • Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentation.
    • Prepare and present technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
    • Collaborate within the formulation team, as well as with other functional teams, to deliver high quality results in an accurate and a time sensitive manner.
    • All other tasks and duties assigned as perceived and agreed upon by management.

    Requirements/Qualifications:

    • Generally met with a bachelor's degree (or equivalent) and 0 – 4 years of industry experience.
    • Degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related science field preferred.
    • Experience with lipid nanoparticle formulation and purification processes, or experience with process development, engineering and manufacturing of biologics drug product processes are highly desired.
    • Hands-on experience working with nucleic acid and/or lipid nanoparticle-based formulations, complex/nanoparticle formulations, or other biological formulations.
    • Working knowledge of tangential flow filtration or other purification processes is preferred.
    • Ability to work in a well-lit heated and/or air-conditioned indoor office and laboratory setting with adequate ventilation. Light physical activity performing non-strenuous daily activities of a productive/technical nature. May require long periods of standing/sitting.
    • Must be comfortable working in a highly innovative, changing, fast-paced environment and able to multi-task.
    • Ability to work under pressure and meet tight deadlines. Has the discipline to stay focused and complete specific tasks.
    • Detail oriented with good organizational skills. Team player with excellent verbal and written communication skills that are critical to the role.

    Salary & Benefits Offerings:

    • Salary range is $60,000 - $105,000/year depending on experience.
    • Performance bonus & Equity
    • 401k Match Program
    • Healthcare Coverage
    • Dental Coverage
    • Vision Coverage
    • Optional Dependent Care Account
    • Flexible Spending Account (FSA)
    • Paid Time Off (PTO)
    • Company Paid Holidays
    • Paid Sick Leave
    • Onsite Fully Stocked Kitchens
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