Jobs
>
Portland

    Postdoctoral Scholar - Portland, United States - OHSU

    OHSU
    OHSU Portland, United States

    2 weeks ago

    Default job background
    Description
    Department Overview

    The Mansoor lab seeks a postdoctoral scholar who is interested in structural biology and drug development.

    The scholar will receive training in the expression and purification of membrane proteins for biophysical and structural analysis, specifically single particle cryogenic electron microscopy (Cryo-EM), as well as training in electrophysiology.

    Applicants must be NIH training grant eligible (US Citizen or Green Card holder).


    Applicants should send a cover letter describing research experience and interests, a CV, and contacts for references to Steven E.

    Mansoor ).


    The Mansoor Lab studies the molecular structure and function of ion channels and receptors in the cardiovascular system to develop novel small molecules for the treatment of conditions such as hypertension, angina, and platelet aggregation.

    Typical techniques and experiments in the lab include, but are not limited to, molecular biology, tissue culture, electrophysiology experiments in both Xenopus oocytes and mammalian cells, and protein expression and purification preparations to get isolated receptor for structural studies, including both X-ray crystallography as well as single particle cryogenic electron microscopy.

    Applicants must have prior biochemistry and molecular biology experience and be comfortable with these types of experiments. Preference will be given to applicants with previous training in membrane protein biochemistry, X-ray crystallography and/or cryogenic electron microscopy.

    Function/Duties of Position

    Primary Research (including planning, granting, execution, analysis, publication) a. Maintain laboratory compliance documentation for human, animal, biological and radiological work. b. Be familiar with lab safety infrastructure and ensure compliance with all safety regulations.c. Interact with biosafety, chemical safety, and safety officers on behalf of the Principal Investigator. a. Generate data and research analysis for investigator's use in preparation of technical reports and publications.b. Assist the PI with manuscript preparation and grant applications.c. Present, or assist in the presentation of, research projects at retreats, seminars, conferences and other OHSU or public venues. Providing training to users on lab practices and protocols, including sample preparation and instrumentation use. Maintain an accurate and detailed laboratory notebook of all experiments performed. Participate in lab meeting. Training of lab personnel and supervision of Research Assistants, students and other lab members.

    Perform routine lab operations, including but not limited to the purchase of laboratory supplies, monitoring supplies and maintaining all laboratory equipment.

    Other responsibilities as assigned by the supervisor in furtherance of the lab's research and the university's missions and goals of teaching, research, patient care, outreach and public service.

    Required Qualifications


    • PhD in biological sciences or a related field
    • Experimental design and interpretation of results
    • Basic molecular biological methods of DNA manipulation and analysis
    • Gene analysis techniques
    • Basic protein analysis techniques such as western blots, immunoprecipitation and immunostaining skills, mammalian cell culture
    • Strong organizational and interpersonal skills
    • Strong scientific curiosity, problem-solving skills and research integrity
    • High attention to detail and accuracy
    • Demonstrated success working independently and as a member of a collaborative team
    • Ability to communicate effectively, in both written and oral formats
    • Working knowledge of office computer applications, such as Word, Excel and PowerPoint
    Preferred Qualifications


    • PhD in Biochemistry or Biophysics/Physics
    • Experience identifying, manipulating, or using nucleic acid aptamers, ideally from de novo selection by SELEX
    • SELEX, nucleic acid and protein purification, chromatography, biophysical binding analysis, analytical biochemistry
    • Programming using Unix
    • Knowledge of membrane protein biochemistry.
    Additional Details

    Position is located at the OHSU Marquam Hill campus in Portland, Oregon.

    The work schedule will be set by the supervising faculty, dictated by the needs of the research and planned experiments.

    Working evenings, weekends and extended hours may be required depending on the needs of the research. Work environment is in an open wet lab, in the presence of laboratory chemicals and automated equipment.

    Employee will need to work at lab benches, desks and/or microscopes for up to 8 hours at a time.

    Ability to perform repetitive lab manipulations (gripping, grasping, reaching, twisting), move lab equipment up to 50 lbs with accommodation, perform image analysis operation and help others with equipment use.

    Personal protective equipment must be worn as required.

    (Gloves, mask/respirator, eyewear, lab coat, etc.) Willing to work with radioactive materials, recombinant viruses, and possibly small animals such as mice and rats.


    Must be able to communicate orally and in writing the results of scientific experiments; must be able to use a standard computer and screen up to 6 hours per day.

    All are welcome

    Oregon Health & Science University values a diverse and culturally competent workforce.

    We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status.

    Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at or
  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    We are seeking a recent PhD graduate or someone with postdoctoral experience to participate in research focused on understanding how herpes simplex virus (HSV) proteins and virus particles are transported in neuronal axons. The position will involve manipulating and producing pla ...

  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    Oregon Health & Science University is a nationally prominent research university and Oregon's only public academic health center. It educates health professionals and scientists and provides leading-edge patient care, community service and biomedical research. · Fellows will have ...

  • OHSU

    Postdoctoral Scholar

    3 weeks ago

    OHSU Portland, United States

    Department Overview · The Mansoor lab seeks a postdoctoral scholar who is interested in structural biology and drug development. The scholar will receive training in the expression and purification of membrane proteins for biophysical and structural analysis, specifically single ...

  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    OHSU Casey Eye Institute is a premier academic medical center providing eye care for adults and children in the Pacific Northwest and beyond. We treat eye conditions from the most straightforward to the most complex, and offer expert care in all ophthalmology specialties. OHSU Ca ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · Oregon Health & Science University is a nationally prominent research university and Oregon's only public academic health center. It educates health professionals and scientists and provides leading-edge patient care, community service and biomedical researc ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The Knight Cardiovascular Institute at Oregon Health & Science University is seeking to recruit a Postdoctoral Scholar to join the group and participate as a fellow in our NIH-funded T32 training program in translational cardiovascular research. Research emp ...

  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    The Oregon Institute of Occupational Health Sciences is an independent research institute within OHSU that is dedicated to health and safety in the workplace. We perform biomedical, clinical, and applied occupational research aimed at promoting health and reducing disease and dis ...

  • OHSU

    Postdoctoral Scholar

    4 weeks ago

    OHSU Portland, United States

    Department Overview · The Carbone Lab at the Oregon Health & Science University is seeking to recruit a Postdoctoral Scholar to join the group and participate to the analysis of funded projects focused on generating epigenetic maps from non-human primate tissues during developmen ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Function/Duties of Position · We are seeking a recent PhD graduate or someone with postdoctoral experience to participate in research focused on understanding how herpes simplex virus (HSV) proteins and virus particles are transported in neuronal axons. The position will involve ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The Wolf lab within the department of Behavioral Neuroscience is seeking a Postdoctoral Scholar. This is a full-time program of advanced academic preparation and research training on NIH-funded projects under the guidance of faculty mentor and senior laborat ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · We are seeking a highly motivated Postdoctoral Scholar to join our team and help move our science forward. The Moran Lab studies how sex hormones shape immune responses in health and disease. We aim to better understand the underlying mechanisms of why immun ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The Barad lab seeks a postdoctoral scholar to investigate cytoskeletal reorganization during intracellular bacterial infection using cellular cryo-electron tomography. The scholar will receive training in sample preparation, tilt series collection, and data ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · OHSU Casey Eye Institute is a premier academic medical center providing eye care for adults and children in the Pacific Northwest and beyond. We treat eye conditions from the most straightforward to the most complex, and offer expert care in all ophthalmolog ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The Oregon Institute of Occupational Health Sciences is an independent research institute within OHSU that is dedicated to health and safety in the workplace. We perform biomedical, clinical, and applied occupational research aimed at promoting health and re ...

  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    The primary mission of the Division of Oncological Sciences at OHSU's Knight Cancer Institute is to better understand cancer through basic, translational and population-based research that improves cancer prevention, detection and treatments for all. Our community of faculty, tra ...

  • Oregon Health & Science University

    Postdoctoral Scholar

    2 weeks ago

    Oregon Health & Science University Portland, United States

    OHSU Casey Eye Institute is a premier academic medical center providing eye care for adults and children in the Pacific Northwest and beyond. We treat eye conditions from the most straightforward to the most complex, and offer expert care in all ophthalmology specialties. · OHSU ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The primary mission of the Division of Oncological Sciences at OHSU's Knight Cancer Institute is to better understand cancer through basic, translational and population-based research that improves cancer prevention, detection and treatments for all. Our com ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · The Gupta lab at the Department of Chemical Physiology and Biochemistry, Oregon Health and Science University (OHSU), Portland, Oregon is opening its doors in January 2024. The lab will be exploring membrane proteins and protein-protein interactions involved ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · Overview: The Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leade ...

  • OHSU

    Postdoctoral Scholar

    2 weeks ago

    OHSU Portland, United States

    Department Overview · This post-doctoral position is an exciting opportunity to develop a novel ex vivo organoid model system for multiple myeloma. You will be working with a group that has already created a similar model for acute myeloid leukemia and we have funding to look at ...