- Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets.
- Oversee design and screening of new AAV constructs for discovery
- Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.
- Collaborate with cross-functional teams to advance drug discovery and development projects.
- Analyze and interpret data from in vitro and in vivo pharmacology &safety studies.
- Research latest scientific trends and technological advances in gene therapy.
- Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics.
- Contribute to the preparation of regulatory documents, including IND submissions.
- Mentor and supervise junior scientists in a cross-functional setting.
- Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications.
- Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field.
- 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.
- Drug Discovery for gene therapy or nucleic acid medicines
- Familiar with AAV gene therapy design and development
- CRO management for conducting in vivo research studies
- Designing in vivo gene therapy studies and dosing
- Experience in biodistribution studies and pharmacology related to gene therapy applications.
- Gene therapy assay development
- Designing IND-enabling studies is a plus.
- Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)
- AAV vector design, titering, dosing
- Expertise in in vivo models for biodistribution and pharmacology studies.
- Strong analytical skills and proficiency in statistical data analysis.
- Excellent communication and project management abilities.
- Graphpad, excel etc.
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Scientist, Discovery Data Science
1 week ago
Johnson & Johnson San Diego, United StatesJob Description · Johnson & Johnson Innovative Medicine is recruiting for a Scientist, Discovery Data Science to help advance Artificial Intelligence/Machine Learning (AI/ML) for Drug Discovery. This position is located at our R&D site in San Diego, CA (La Jolla area). · At Jo ...
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Senior Scientist, Discovery Biology
2 weeks ago
Light Horse Therapeutics San Diego, United StatesLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets fo ...
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Research Scientist, Discovery Core
2 days ago
Vertex Pharmaceuticals San Diego, United States**Job Description**: · **Research Scientist, Discovery Core** · **Key Responsibilities**: · - Execute a variety of target and phenotypic cell-based assays to support early lead discovery programs using automation tools. · - Effectively collate and interpret data systematically an ...
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Senior Scientist, Discovery Data Science
1 week ago
Johnson & Johnson San Diego, United StatesJob Description · Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Discovery Data Science to help advance Artificial Intelligence/Machine Learning (AI/ML) for Drug Discovery. The preferred location for this position is our R&D site in La Jolla - CA. C ...
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Zentalis San Diego, United StatesJob Description · Job DescriptionSalary: $90-125k · JOB SUMMARY: · Responsible for designing and conducting research studies to support our drug discovery programs, including target validation, structure-activity relationship assessment, biomarker discovery, and mechanism of act ...
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Scientific Sr. Director – Peptide Discovery Team
2 weeks ago
Lilly San Diego, United States Full timeWe're looking for people who are determined to make life better for people around the world. · This is a technical leadership position (Scientific Sr. Director – Group Leader) in the Peptide Discovery Team within Biotechnology Discovery Research in San Diego. The individual will ...
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Sr. Scientist, Translational Genetics
3 weeks ago
BioPhase San Diego, United StatesThe ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally. · Responsibilities: · The Sci ...
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The Higgins Group, Inc. San Diego, United StatesVividion Therapeutics seeks a decisive yet collaborative leader with deep translational and early clinical development experience in immunology to drive forward its pipeline of novel small-molecule precision medicines and build a first-class team. The S/VP, Immunology will be a h ...
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Lilly San Diego, United States Full timeWe're looking for people who are determined to make life better for people around the world. · The Biotechnology Discovery Research Division at LBC-San Diego, responsible for generating, characterizing, and optimizing biotherapeutics from lead generation through lead optimization ...
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Principal Scientist
3 weeks ago
BioTalent San Diego, United StatesBioTalent has partnered with a biotechnology business based in San Diego who are looking for a Principal Scientist with a focus on proteomics. · This is an ideal position for an expert in proteomics that is keen to work within an innovative organisation with potential to grow int ...
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InsideHigherEd San Diego, United States Faculty Jobs ,Job Summary · The Metallo lab aims to understand how metabolism contributes to progression of cancer and other age-related diseases. We study how alterations in carbohydrate, amino acid, and lipid metabolism across distinct organs influence cellular processes and lead to cancer, ...
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Biologist (3-5 years)
2 weeks ago
Global Pharma Tek San Diego, United States ContractTitle: Biologist · Location: San Diego, CA · Duration: Months · Shift: st M-F AM- PM · Conduct experiments to identify and validate drug targets. · Support assay design, optimization, validation, and data analyses. · Design and execute molecular and cell biology experiments. ...
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Sr. Associate Scientist, Biology
3 weeks ago
RayzeBio San Diego, United StatesJob Title: Sr. Associate Scientist I or II, Biology · Location: San Diego · Background · RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company ...
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Senior Scientist
3 weeks ago
Global Life Science Hub San Diego, United StatesGlobal Life Science Hub has a longstanding partnership with an innovative biotechnology company that is revolutionizing the field with its groundbreaking platform for real-time detection and analysis of biological molecules. This platform enables the swift identification and anal ...
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Associate Director, Bioanalysis
2 weeks ago
WuXi AppTec San Diego, United StatesOverview · HD Biosciences Inc. a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceuticals. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead d ...
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Senior Scientist
3 weeks ago
Global Life Science Hub San Diego, United StatesGlobal Life Science Hub has a longstanding partnership with an innovative biotechnology company that is revolutionizing the field with its groundbreaking platform for real-time detection and analysis of biological molecules. This platform enables the swift identification and anal ...
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Accounting Manager
2 weeks ago
Sapient Bioanalytics, LLC San Diego, United StatesAbout UsWe are a purpose-built biomarker discovery organization headquartered in San Diego, CA providing bespoke services for metabolomics, lipidomics, and proteomics data generation and analysis. We leverage high-throughput technologies, backed by an advanced biocomputational fr ...
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Postdoctoral Fellow
2 weeks ago
InsideHigherEd San Diego, United States Faculty Jobs ,Job Summary · This postdoctoral position will perform fly genetics, molecular biology, immunohistology, and behavior analysis related to circadian rhythm and human disease model in Satchidananda Panda's lab. · 1) Supervisory · The postdoc will directly supervise, research assis ...
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Principal Gifts Officer
5 days ago
InsideHigherEd San Diego, United StatesJob location is at 10240 Science Center Dr, San Diego, CA 92121 · Reporting to the Senior Principal Gifts Officer, the Principal Gifts Officer is a critically important role, primarily responsible as a member of the External Relations (ER) team for identifying and closing major g ...
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Clinical Postdoctoral Fellow
2 weeks ago
InsideHigherEd San Diego, United States Faculty Jobs ,Job Summary · This postdoctoral position will supervise and perform human epidemiological, clinical intervention, and observational studies related to circadian rhythms and eating patterns in Satchin Panda's lab at the Salk Institute. · 1) Supervisory · The postdoc will directly ...
Principal/Senior Scientist, Discovery - San Diego, United States - Lexeo Therapeutics
Description
About LexeoLexeo Therapeutics is a New York City-based, clinical-stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer's disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer's disease programs.
Primary Responsibilities
Depending on qualifications and overall experience, base salary is likely to $150,000 - $190,000 per year.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Principal/Senior Scientist, Discovery professionals in San Diego
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