- Conduct in vivo procedures to evaluate efficacy of therapy candidates in rodent models, primarily mice and rat.
- Perform standard mouse procedures including blood collection, injections, necropsies, and tissue collection in compliance with established protocols.
- Conduct in life safety assessments: monitor body weight, clinical observations, and survival of mice.
- Maintain accurate records of animal assessments and study activities; document experimental data in laboratory notebook, including a description of the study purpose, activities performed, observed results, and variation from expected data patterns.
- Data entry into animal management software.
- Analyze and present in vivo data to project team.
- Participate in cross-functional collaborations to advance broad company goals and objectives.
- Comply with all laboratory safety procedures.
- Bachelor in Biosciences with at least 5+ years of industry/academia experience or MSc with 2+ years of industry experience
- Bachelor in Biosciences with at least 2+ years of industry/academia experience or MSc with 0+ years of industry experience
- Proficient in standard in vivo techniques (animal handling, blood collection, dosing (SQ, IV, IM, and IP), necropsy, tissue dissections)
- Execution of both efficacy as well as PK/PD models in rodents
- Familiar with IACUC and compliance requirements
- Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy, gene editing, and/or gene silencing) not required but desirable.
- Thrives in a dynamic and fast-paced research environment. Ability to work on weekends on a rotating schedule.
- Collaborative mindset and a willingness to work with different teams.
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Pioneering Medicines: Research Associate II - Cambridge, United States - Flagship Pioneering, Inc.
Description
What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need.
About Flagship Pioneering:
Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability.
Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.
Position Summary:
We are seeking a Research Associate / Sr.
Research Associate of in vivo Pharmacology who will be responsible for independently developing and performing studies in animal models across different disease areas.
Additional responsibilities include applying a wide range of in vitro and in vivo approaches to understand the mechanism of action of various therapeutic agents.
This individual will interact seamlessly with Discovery Biology and other Discovery groups to help execute on company strategy.The major focus of this position will be the in vivo evaluation of novel biological and small molecule therapeutic agents, including RNA-based approaches that will support the drug discovery efforts across multiple programs form target validation to identification of clinical candidates.
Responsibilities:
Education Requirements:
For Senior RA
For Research Associate II:
Additional Requirements:
* experience using rodent models of metabolism, cardiopulmonary, cardiorenal, or oncology to support drug discovery and development.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies:
Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates.
The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team.
Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
